Valerie R. Stolberg
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View article: Human lung cDC1 drive increased perforin-mediated NK cytotoxicity in chronic obstructive pulmonary disease
Human lung cDC1 drive increased perforin-mediated NK cytotoxicity in chronic obstructive pulmonary disease Open
In chronic obstructive pulmonary disease (COPD), lung natural killer cells (NKs) lyse autologous lung epithelial cells in vitro, but underlying mechanisms and their relationship to epithelial cell apoptosis in vivo are undefined. Although …
View article: Intermediate (CD14++ CD16+) Monocytes Correlate with Parametric Response Mapping of Functional Small Airways Disease: Spiromics Immunophenotyping Sub-Study
Intermediate (CD14++ CD16+) Monocytes Correlate with Parametric Response Mapping of Functional Small Airways Disease: Spiromics Immunophenotyping Sub-Study Open
View article: Type-1 Classical Dendritic Cells from Human Lungs Demonstrate an Enhanced Ability to Prime Natural Killer Cells
Type-1 Classical Dendritic Cells from Human Lungs Demonstrate an Enhanced Ability to Prime Natural Killer Cells Open
View article: Erratum for Xu et al., “Disruption of Early Tumor Necrosis Factor Alpha Signaling Prevents Classical Activation of Dendritic Cells in Lung-Associated Lymph Nodes and Development of Protective Immunity against Cryptococcal Infection”
Erratum for Xu et al., “Disruption of Early Tumor Necrosis Factor Alpha Signaling Prevents Classical Activation of Dendritic Cells in Lung-Associated Lymph Nodes and Development of Protective Immunity against Cryptococcal Infection” Open
View article: Lung Dendritic Cells Drive Natural Killer Cytotoxicity in Chronic Obstructive Pulmonary Disease via IL-15Rα
Lung Dendritic Cells Drive Natural Killer Cytotoxicity in Chronic Obstructive Pulmonary Disease via IL-15Rα Open
Heightened NK cytotoxicity against lung epithelial cells in COPD results primarily from lung DC-mediated priming via IL-15 trans-presentation on IL-15Rα. Future studies are required to test whether increased NK cytotoxicity contributes to …
View article: Alveolar eosinophilia in current smokers with chronic obstructive pulmonary disease in the SPIROMICS cohort
Alveolar eosinophilia in current smokers with chronic obstructive pulmonary disease in the SPIROMICS cohort Open
View article: Disruption of Early Tumor Necrosis Factor Alpha Signaling Prevents Classical Activation of Dendritic Cells in Lung-Associated Lymph Nodes and Development of Protective Immunity against Cryptococcal Infection
Disruption of Early Tumor Necrosis Factor Alpha Signaling Prevents Classical Activation of Dendritic Cells in Lung-Associated Lymph Nodes and Development of Protective Immunity against Cryptococcal Infection Open
Anti-tumor necrosis factor alpha (anti-TNF-α) therapies have been increasingly used to treat inflammatory diseases and are associated with increased risk of invasive fungal infections, including Cryptococcus neoformans infection. Using a m…
View article: MicroRNA-34a Negatively Regulates Efferocytosis by Tissue Macrophages in Part via SIRT1
MicroRNA-34a Negatively Regulates Efferocytosis by Tissue Macrophages in Part via SIRT1 Open
Apoptotic cell (AC) clearance (efferocytosis) is an evolutionarily conserved process essential for immune health, particularly to maintain self-tolerance. Despite identification of many recognition receptors and intracellular signaling com…
View article: Glucocorticoid-Augmented Efferocytosis Inhibits Pulmonary Pneumococcal Clearance in Mice by Reducing Alveolar Macrophage Bactericidal Function
Glucocorticoid-Augmented Efferocytosis Inhibits Pulmonary Pneumococcal Clearance in Mice by Reducing Alveolar Macrophage Bactericidal Function Open
Inhaled corticosteroids (ICS) increase community-acquired pneumonia (CAP) incidence in patients with chronic obstructive pulmonary disease (COPD) by unknown mechanisms. Apoptosis is increased in the lungs of COPD patients. Uptake of apopto…
View article: Design of a multi-center immunophenotyping analysis of peripheral blood, sputum and bronchoalveolar lavage fluid in the Subpopulations and Intermediate Outcome Measures in COPD Study (SPIROMICS)
Design of a multi-center immunophenotyping analysis of peripheral blood, sputum and bronchoalveolar lavage fluid in the Subpopulations and Intermediate Outcome Measures in COPD Study (SPIROMICS) Open
View article: Design of a multi-center immunophenotyping analysis of peripheral blood, sputum and bronchoalveolar lavage fluid in the Subpopulations and Intermediate Outcome Measures in COPD Study (SPIROMICS)
Design of a multi-center immunophenotyping analysis of peripheral blood, sputum and bronchoalveolar lavage fluid in the Subpopulations and Intermediate Outcome Measures in COPD Study (SPIROMICS) Open
BackgroundSubpopulations and Intermediate Outcomes in COPD Study (SPIROMICS) is a multi-center longitudinal, observational study to identify novel phenotypes and biomarkers of chronic obstructive pulmonary disease (COPD). In a subset of 30…