Chi V. Dang
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View article: Awake Prone Positioning in Patients With COVID-19 Respiratory Failure
Awake Prone Positioning in Patients With COVID-19 Respiratory Failure Open
Importance Awake prone positioning (APP) has shown inconstant associations with improved clinical outcomes in nonintubated patients with COVID-19 developing severe pneumonia. Objective To evaluate the effects of APP on the need for intubat…
View article: Androgen receptor drives polyamine synthesis creating a vulnerability for prostate cancer
Androgen receptor drives polyamine synthesis creating a vulnerability for prostate cancer Open
Supraphysiological androgen (SPA) treatment can paradoxically restrict growth of castration-resistant prostate cancer with high androgen receptor (AR) activity, which is the basis for use of Bipolar Androgen Therapy (BAT) for patients with…
View article: RNA Polymerase III Regulates HIV Replication and Latency
RNA Polymerase III Regulates HIV Replication and Latency Open
The elimination of HIV latent reservoirs is an extremely challenging task due to the interplay of multiple mechanisms regulating latency. Thus, we need to identify novel strategies to target heterogeneous reservoirs uniformly. Recent repor…
View article: Imaging the uptake and metabolism of glutamine in prostate tumor models using CEST MRI
Imaging the uptake and metabolism of glutamine in prostate tumor models using CEST MRI Open
Glutamine metabolism is upregulated in many cancers. While multiple glutamine imaging agents have been developed and translated to clinical use, the short half-lives of their signal and instability in vivo limit the aspects of glutamine me…
View article: Automated Neuron Labelling Enables Generative Steering and Interpretability in Protein Language Models
Automated Neuron Labelling Enables Generative Steering and Interpretability in Protein Language Models Open
Protein language models (PLMs) encode rich biological information, yet their internal neuron representations are poorly understood. We introduce the first automated framework for labeling every neuron in a PLM with biologically grounded na…
View article: Public Opinion and it’s Influence on Technology Governance in the Age of Digital Transformation
Public Opinion and it’s Influence on Technology Governance in the Age of Digital Transformation Open
This study examines how social public opinion affects technology governance in order to examine the ways in which digital transformation affects various government agencies. Our method breaks out the precise effects of digital transformati…
View article: Lineage dependence of the neuroblastoma surfaceome defines tumor cell state-dependent and -independent immunotherapeutic targets
Lineage dependence of the neuroblastoma surfaceome defines tumor cell state-dependent and -independent immunotherapeutic targets Open
Background Neuroblastoma is a heterogeneous disease with adrenergic (ADRN)-like cells and therapy-resistant mesenchymal (MES)-like cells driven by distinct transcription factor networks. Here, we investigate the expression of immunotherape…
View article: Feature Graph Construction With Static Features for Malware Detection
Feature Graph Construction With Static Features for Malware Detection Open
Malware can greatly compromise the integrity and trustworthiness of information and is in a constant state of evolution. Existing feature fusion‐based detection methods generally overlook the correlation between features. And mere concaten…
View article: OPPORTUNITIES AND CHALLENGES FOR TARGETING CANCER METABOLISM.
OPPORTUNITIES AND CHALLENGES FOR TARGETING CANCER METABOLISM. Open
Otto Warburg sparked the field of cancer metabolism in the 1920s through his observations that human and animal cancer tissues converted significant amounts of glucose to lactate with an elusive underlying mechanism. The discovery of oncog…
View article: Androgen receptor drives polyamine synthesis creating a vulnerability for prostate cancer
Androgen receptor drives polyamine synthesis creating a vulnerability for prostate cancer Open
Supraphysiological androgen (SPA) treatment can paradoxically restrict growth of castration-resistant prostate cancer with high androgen receptor (AR) activity, which is the basis for use of Bipolar Androgen Therapy (BAT) for patients with…
View article: Hypermetabolic state is associated with circadian rhythm disruption in mouse and human cancer cells
Hypermetabolic state is associated with circadian rhythm disruption in mouse and human cancer cells Open
Crosstalk between metabolism and circadian rhythms is a fundamental building block of multicellular life, and disruption of this reciprocal communication could be relevant to disease. Here, we investigated whether maintenance of circadian …
View article: Lineage-dependence of the neuroblastoma surfaceome defines tumor cell state-dependent and independent immunotherapeutic targets
Lineage-dependence of the neuroblastoma surfaceome defines tumor cell state-dependent and independent immunotherapeutic targets Open
Background Neuroblastoma is a heterogeneous disease with adrenergic (ADRN)- and therapy resistant mesenchymal (MES)-like cells driven by distinct transcription factor networks. Here, we investigate the expression of immunotherapeutic targe…
View article: The Warburg Effect Revisited through Blood and Electron Flow
The Warburg Effect Revisited through Blood and Electron Flow Open
The Warburg effect describes the propensity of many cancers to consume glucose avidly and convert it to lactate in the presence of oxygen. The benefit of the Warburg effect on cancer cells remains enigmatic, particularly because extracellu…
View article: A194 EARLY LIFE WESTERN-TYPE DIET ACCELERATES THE ONSET OF MURINE IL-10 KO COLITIS
A194 EARLY LIFE WESTERN-TYPE DIET ACCELERATES THE ONSET OF MURINE IL-10 KO COLITIS Open
Background Early life is a critical time for gut microbiome and immune development, including the establishment of proper host-microbe interactions. While exposures to western world environmental factors are associated with inflammatory bo…
View article: MYC-driven increases in mitochondrial DNA copy number occur early and persist throughout prostatic cancer progression
MYC-driven increases in mitochondrial DNA copy number occur early and persist throughout prostatic cancer progression Open
Increased mitochondrial function may render some cancers vulnerable to mitochondrial inhibitors. Since mitochondrial function is regulated partly by mitochondrial DNA copy number (mtDNAcn), accurate measurements of mtDNAcn could help revea…
View article: Hypermetabolic state is associated with circadian rhythm disruption in mouse and human cancer cells
Hypermetabolic state is associated with circadian rhythm disruption in mouse and human cancer cells Open
Crosstalk between cellular metabolism and circadian rhythms is a fundamental building block of multicellular life, and disruption of this reciprocal communication could be relevant to degenerative disease, including cancer. Here, we invest…
View article: MYC disrupts transcriptional and metabolic circadian oscillations in cancer and promotes enhanced biosynthesis
MYC disrupts transcriptional and metabolic circadian oscillations in cancer and promotes enhanced biosynthesis Open
The molecular circadian clock, which controls rhythmic 24-hour oscillation of genes, proteins, and metabolites in healthy tissues, is disrupted across many human cancers. Deregulated expression of the MYC oncoprotein has been shown to alte…
View article: Cancer Metabolism Historical Perspectives: A Chronicle of Controversies and Consensus
Cancer Metabolism Historical Perspectives: A Chronicle of Controversies and Consensus Open
A century ago, Otto Warburg's work sparked the field of cancer metabolism, which has since taken a tortuous path. As evidence accumulated over the decades, consensus views of causes of cancer emerged, whereby genetic and epigenetic oncogen…
View article: Supplementary Figures 1-5, Tables 1-2 from Na<sup>+</sup>/H<sup>+</sup>-exchanger 1 Enhances Antitumor Activity of Engineered NK-92 Natural Killer Cells
Supplementary Figures 1-5, Tables 1-2 from Na<sup>+</sup>/H<sup>+</sup>-exchanger 1 Enhances Antitumor Activity of Engineered NK-92 Natural Killer Cells Open
Supplementary Fig. S1. CA9 fails to enhance the cytolytic activity of NK-92 cells in vitro. Supplementary Fig. S2. NHE1 enhances in vitro cytotoxicity of NK-92 cells without affecting proliferation or survival. Supplementary Fig. S3. Repre…
View article: Supplementary Figures 1-5, Tables 1-2 from Na<sup>+</sup>/H<sup>+</sup>-exchanger 1 Enhances Antitumor Activity of Engineered NK-92 Natural Killer Cells
Supplementary Figures 1-5, Tables 1-2 from Na<sup>+</sup>/H<sup>+</sup>-exchanger 1 Enhances Antitumor Activity of Engineered NK-92 Natural Killer Cells Open
Supplementary Fig. S1. CA9 fails to enhance the cytolytic activity of NK-92 cells in vitro. Supplementary Fig. S2. NHE1 enhances in vitro cytotoxicity of NK-92 cells without affecting proliferation or survival. Supplementary Fig. S3. Repre…
View article: Data from Na<sup>+</sup>/H<sup>+</sup>-exchanger 1 Enhances Antitumor Activity of Engineered NK-92 Natural Killer Cells
Data from Na<sup>+</sup>/H<sup>+</sup>-exchanger 1 Enhances Antitumor Activity of Engineered NK-92 Natural Killer Cells Open
Adoptive cell transfer (ACT) immunotherapy has remarkable efficacy against some hematologic malignancies. However, its efficacy in solid tumors is limited by the adverse tumor microenvironment (TME) conditions, most notably that acidity in…
View article: Data from Na<sup>+</sup>/H<sup>+</sup>-exchanger 1 Enhances Antitumor Activity of Engineered NK-92 Natural Killer Cells
Data from Na<sup>+</sup>/H<sup>+</sup>-exchanger 1 Enhances Antitumor Activity of Engineered NK-92 Natural Killer Cells Open
Adoptive cell transfer (ACT) immunotherapy has remarkable efficacy against some hematologic malignancies. However, its efficacy in solid tumors is limited by the adverse tumor microenvironment (TME) conditions, most notably that acidity in…
View article: Data from Bcl-xL Enforces a Slow-Cycling State Necessary for Survival in the Nutrient-Deprived Microenvironment of Pancreatic Cancer
Data from Bcl-xL Enforces a Slow-Cycling State Necessary for Survival in the Nutrient-Deprived Microenvironment of Pancreatic Cancer Open
Solid tumors possess heterogeneous metabolic microenvironments where oxygen and nutrient availability are plentiful (fertile regions) or scarce (arid regions). While cancer cells residing in fertile regions proliferate rapidly, most cancer…