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View article: Tissue Engineering and Regenerative Medicine: Perspectives and Challenges
Tissue Engineering and Regenerative Medicine: Perspectives and Challenges Open
From the pioneering days of cell therapy to the achievement of bioprinting organs, tissue engineering, and regenerative medicine have seen tremendous technological advancements, offering solutions for restoring damaged tissues and organs. …
View article: Blocking autophagosome closure manifests the roles of mammalian Atg8-family proteins in phagophore formation and expansion during nutrient starvation
Blocking autophagosome closure manifests the roles of mammalian Atg8-family proteins in phagophore formation and expansion during nutrient starvation Open
Macroautophagy/autophagy, an evolutionarily conserved cellular degradation pathway, involves phagophores that sequester cytoplasmic constituents and mature into autophagosomes for subsequent lysosomal delivery. The ATG8 gene family, compri…
View article: Translating Membrane Geometry into Protein Function: Multifaceted Membrane Interactions of Human Atg3 Promote LC3-Phosphatidylethanolamine Conjugation during Autophagy
Translating Membrane Geometry into Protein Function: Multifaceted Membrane Interactions of Human Atg3 Promote LC3-Phosphatidylethanolamine Conjugation during Autophagy Open
Autophagosome formation is the hallmark of macroautophagy (herein referred to as autophagy) and requires the covalent conjugation of LC3 proteins (or Atg8 in yeast) to the amino headgroup of PE (phosphatidylethanolamine) lipids. Atg3 is an…
View article: An N-terminal conserved region in human Atg3 couples membrane curvature sensitivity to conjugase activity during autophagy
An N-terminal conserved region in human Atg3 couples membrane curvature sensitivity to conjugase activity during autophagy Open
During autophagy the enzyme Atg3 catalyzes the covalent conjugation of LC3 to the amino group of phosphatidylethanolamine (PE) lipids, which is one of the key steps in autophagosome formation. Here, we have demonstrated that an N-terminal …
View article: FTY720 induces non-canonical phosphatidylserine externalization and cell death in acute myeloid leukemia
FTY720 induces non-canonical phosphatidylserine externalization and cell death in acute myeloid leukemia Open
FTY720 (fingolimod) is a FDA-approved sphingosine analog that is phosphorylated in vivo to modulate sphingosine-1-phosphate receptor (S1PR) signaling for immunosuppression in patients with refractory multiple sclerosis. FTY720 also exhibit…
View article: Effect of y irradiation on autophagic flux in glioblastoma cells that express LC3B-eGFP-mCherry
Effect of y irradiation on autophagic flux in glioblastoma cells that express LC3B-eGFP-mCherry Open
Journal Article Effect of y irradiation on autophagic flux in glioblastoma cells that express LC3B-eGFP-mCherry Get access Linda S Yasui, Linda S Yasui Northern Illinois University, Department of Biological Sciences, DeKalb, IL. USA Search…