Ronald Van Eyken
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View article: Engineering non-exponential proliferation in <i>Escherichia coli</i> using functionalized protein aggregates
Engineering non-exponential proliferation in <i>Escherichia coli</i> using functionalized protein aggregates Open
Uncurbed exponential proliferation might not always be required for genetically modified microorganisms, and might even cause unpredictable liabilities in their behavior and impact. We therefore constructed a bacterial chassis that adheres…
View article: Evolutionary trade-off between heat shock resistance, growth at high temperature, and virulence expression in <i>Salmonella</i> Typhimurium
Evolutionary trade-off between heat shock resistance, growth at high temperature, and virulence expression in <i>Salmonella</i> Typhimurium Open
Understanding the evolutionary dynamics of foodborne pathogens throughout our food production chain is of utmost importance. In this study, we reveal that Salmonella Typhimurium can readily and reproducibly acquire vastly increased heat sh…
View article: Protein aggregates act as a deterministic disruptor during bacterial cell size homeostasis
Protein aggregates act as a deterministic disruptor during bacterial cell size homeostasis Open
View article: Erratum for Mortier and Gayán et al., “Gene Erosion Can Lead to Gain-of-Function Alleles That Contribute to Bacterial Fitness”
Erratum for Mortier and Gayán et al., “Gene Erosion Can Lead to Gain-of-Function Alleles That Contribute to Bacterial Fitness” Open
Volume 12, no. 4, e01129-21, 2021, https://doi.org/10.1128/mBio.01129-21. For the authors Ladan Khodaparast, Laleh Khodaparast, Bert Houben, Frederic Rousseau, and Joost Schymkowitz, the affiliation "VIB, Center for Brain & Disease Researc…
View article: Gene Erosion Can Lead to Gain-of-Function Alleles That Contribute to Bacterial Fitness
Gene Erosion Can Lead to Gain-of-Function Alleles That Contribute to Bacterial Fitness Open
Despite our extensive knowledge of the genetic regulation of heat shock proteins (HSPs), the evolutionary routes that allow bacteria to adaptively tune their HSP levels and corresponding proteostatic robustness have been explored less. In …