Van Ngu Trinh
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View article: Crosstalk between genomic variants and DNA methylation in <i>FLT3</i> mutant acute myeloid leukemia
Crosstalk between genomic variants and DNA methylation in <i>FLT3</i> mutant acute myeloid leukemia Open
Acute myeloid leukemia (AML) is a type of blood cancer with diverse genetic variations and DNA methylation alterations. By studying the interaction of gene mutations, expression, and DNA methylation, we aimed to gain valuable insights into…
View article: Apolipoprotein L1 is a tumor suppressor in clear cell renal cell carcinoma metastasis
Apolipoprotein L1 is a tumor suppressor in clear cell renal cell carcinoma metastasis Open
The 5-year survival rate of kidney cancer drops dramatically from 93% to 15% when it is metastatic. Metastasis constitutes for 30% of kidney cancer cases, in which clear cell renal cell carcinoma (ccRCC) is the most prominent subtype. By s…
View article: EGFR is a master switch between immunosuppressive and immunoactive tumor microenvironment in inflammatory breast cancer
EGFR is a master switch between immunosuppressive and immunoactive tumor microenvironment in inflammatory breast cancer Open
Inflammatory breast cancer (IBC), the most aggressive breast cancer subtype, is driven by an immunosuppressive tumor microenvironment (TME). Current treatments for IBC have limited efficacy. In a clinical trial (NCT01036087), an anti-EGFR …
View article: Downregulation of glypican-4 facilitates breast cancer progression by inducing cell migration and proliferation
Downregulation of glypican-4 facilitates breast cancer progression by inducing cell migration and proliferation Open
Glypican-4 (GPC-4) is a heparan sulphate glycoprotein, associated with cell membrane via a Glycosyl phosphatidyl (GPI)-anchor. It is involved in cell migration, cell growth, differentiation and morphogenesis as well as chemoresistance and …
View article: Promotion of tumor progression and cancer stemness by MUC15 in thyroid cancer via the GPCR/ERK and integrin-FAK signaling pathways
Promotion of tumor progression and cancer stemness by MUC15 in thyroid cancer via the GPCR/ERK and integrin-FAK signaling pathways Open
Thyroid cancer is the fifth most common cancer diagnosed in women worldwide. Notwithstanding advancements in the prognosis and treatment of thyroid cancer, 10–20% of thyroid cancer patients develops chemotherapeutic resistance and experien…
View article: mirRICH, a simple method to enrich the small RNA fraction from over-dried RNA pellets
mirRICH, a simple method to enrich the small RNA fraction from over-dried RNA pellets Open
Techniques to isolate the small RNA fraction (<200nt) by column-based methods are commercially available. However, their use is limited because of the relatively high cost. We found that large RNA molecules, including mRNAs and rRNAs, are …
View article: ID: 1015 Taraxacum officinale (dandelion) extract efficiently inhibited the breast cancer stem cell proliferation
ID: 1015 Taraxacum officinale (dandelion) extract efficiently inhibited the breast cancer stem cell proliferation Open
Introduction: Breast cancer stem cells (BCSCs) play an important role in breast cancer initiation, metastasis, recurrence, and drug resistance. Therefore, targeting BCSCs is an essential strategy to suppress cancer growth. This study aimed…
View article: Targeting breast cancer stem cells by dendritic cell vaccination in humanized mice with breast tumor: preliminary results
Targeting breast cancer stem cells by dendritic cell vaccination in humanized mice with breast tumor: preliminary results Open
These results suggested that targeting BCSCs with DCs is a promising therapy for BC.
View article: Taraxacum officinale dandelion extracts efficiently inhibited the breast cancer stem cell proliferation
Taraxacum officinale dandelion extracts efficiently inhibited the breast cancer stem cell proliferation Open
Background: Breast cancer stem cells (BCSCs) play an important role in breast cancer initiation, metastasis, recurrence, and drug resistance. Therefore, targeting BCSCs is an essential strategy to suppress cancer growth. This study aimed t…
View article: Low concentrations of 5-aza-2&#39;-deoxycytidine induce breast cancer stem cell differentiation by triggering tumor suppressor gene expression
Low concentrations of 5-aza-2'-deoxycytidine induce breast cancer stem cell differentiation by triggering tumor suppressor gene expression Open
DAC reduced breast cancer cell survival and induced differentiation through reexpression of tumor suppressor genes. These results indicate the potential of DAC in targeting specific chemotherapy-resistant cells within a tumor.