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View article: The histone chaperone Spt6 controls chromatin structure through its conserved N-terminal domain
The histone chaperone Spt6 controls chromatin structure through its conserved N-terminal domain Open
Summary The disassembly and reassembly of nucleosomes by histone chaperones is an essential activity during eukaryotic transcription elongation. This highly conserved process maintains chromatin integrity by transiently removing nucleosome…
View article: The Impact of Lens Epithelium-Derived Growth Factor p75 Dimerization on Its Tethering Function
The Impact of Lens Epithelium-Derived Growth Factor p75 Dimerization on Its Tethering Function Open
The transcriptional co-activator lens epithelium-derived growth factor/p75 (LEDGF/p75) plays an important role in the biology of the cell and in several human diseases, including MLL-rearranged acute leukemia, autoimmunity, and HIV-1 infec…
View article: Multivalency of nucleosome recognition by LEDGF
Multivalency of nucleosome recognition by LEDGF Open
Eukaryotic transcription is dependent on specific histone modifications. Their recognition by chromatin readers triggers complex processes relying on the coordinated association of transcription regulatory factors. Although various modific…
View article: An allosteric HTRA1-calpain 2 complex with restricted activation profile
An allosteric HTRA1-calpain 2 complex with restricted activation profile Open
Significance Classic serine proteases are synthesized as inactive precursors that are proteolytically processed, resulting in irreversible activation. We report an alternative and reversible mechanism of activation that is executed by an i…
View article: A ubiquitous disordered protein interaction module orchestrates transcription elongation
A ubiquitous disordered protein interaction module orchestrates transcription elongation Open
Organized by unstructured motifs The high degree of conservation in protein sequences thought to be unstructured has hinted that these regions may have important biological functions. Although unstructured regions are widely viewed to be c…
View article: Epigenetic silencing of serine protease HTRA1 drives polyploidy
Epigenetic silencing of serine protease HTRA1 drives polyploidy Open
Downregulation of HTRA1 causes a number of phenotypes that are hallmarks of cancer cells suggesting that the methylation state of the HtrA1 promoter may be used as a biomarker for tumour cells or cells at risk of transformation.
View article: Additional file 1: of Epigenetic silencing of serine protease HTRA1 drives polyploidy
Additional file 1: of Epigenetic silencing of serine protease HTRA1 drives polyploidy Open
contains Supplementary method (Chromatin immunoprecipitation) and Table S1 (oligonucleotides used). Additional figure shows colocalisation of HTRA1 and microtubules in SW480 cells. (ZIP 394 kb)