Vanessa A. Guzman
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View article: Relationships of hematocrit concentration with dementia from a multiethnic population-based study
Relationships of hematocrit concentration with dementia from a multiethnic population-based study Open
Objective Red blood cell (RBC) concentration impacts cerebrovascular disease, yet it is unclear whether RBC concentrations relate to dementia risk, particularly in racially/ethnically diverse cohorts. We investigated whether RBC concentrat…
View article: Young Onset Neurocognitive Impairment, Amyloid Positivity, and Psychiatric Symptoms in Underrepresented Populations in the HABS‐HD Cohort
Young Onset Neurocognitive Impairment, Amyloid Positivity, and Psychiatric Symptoms in Underrepresented Populations in the HABS‐HD Cohort Open
Background Adults from underrepresented populations (URPs), including non‐Latinx NLB (NLB) and Latinx adults, have higher Alzheimer’s disease and related dementia (ADRD) rates than non‐Latinx Whites (NLWs). Young onset dementia is diagnose…
View article: Vascular Aging Markers and Blood Biomarkers of Neurodegeneration
Vascular Aging Markers and Blood Biomarkers of Neurodegeneration Open
Background Age‐related changes in the systemic and cerebral vasculature adversely affect brain health and may contribute to neurodegeneration. However, the relationship between markers of systemic (arterial stiffness) and cerebral (flow pu…
View article: The Alzheimer's Disease Neuroimaging Initiative‐4 (ADNI‐4) Engagement Core: A culturally informed, community‐engaged research (CI‐CER) model to advance brain health equity
The Alzheimer's Disease Neuroimaging Initiative‐4 (ADNI‐4) Engagement Core: A culturally informed, community‐engaged research (CI‐CER) model to advance brain health equity Open
INTRODUCTION The Alzheimer's Disease Neuroimaging Initiative‐4 (ADNI‐4) Engagement Core was launched to advance Alzheimer's disease (AD) and AD‐related dementia (ADRD) health equity research in underrepresented populations (URPs). We descr…
View article: Relationships of hematocrit concentration with dementia from a multiethnic population-based study
Relationships of hematocrit concentration with dementia from a multiethnic population-based study Open
Objective: Red blood cell (RBC) concentration impacts cerebrovascular disease, yet it is unclear whether RBC concentrations relate to dementia risk, particularly in racially/ethnically diverse cohorts. We investigated whether RBC concentra…
View article: Association of brain arterial diameters with demographic and anatomical factors in a multi-national pooled analysis of cohort studies
Association of brain arterial diameters with demographic and anatomical factors in a multi-national pooled analysis of cohort studies Open
Background and Purpose Brain arterial diameters are markers of cerebrovascular disease. Demographic and anatomical factors may influence arterial diameters. We hypothesize that age, sex, height, total cranial volume (TCV), and persistent f…
View article: Age-friendly practices during the COVID-19 pandemic: Findings from a scoping review
Age-friendly practices during the COVID-19 pandemic: Findings from a scoping review Open
Background The COVID-19 pandemic called for innovation and leverage of existing age-friendly practices to promote older people's functional ability and enable them to contribute to their communities and enjoy life. Our aim was to explore t…
View article: The Longitudinal Effects of Blood Pressure and Hypertension on Neurocognitive Performance in People Living With HIV
The Longitudinal Effects of Blood Pressure and Hypertension on Neurocognitive Performance in People Living With HIV Open
Background: Hypertension (HTN) and HIV are salient risk factors for cerebral small vessel disease and neurocognitive (NC) impairment, yet the effects of HTN on NC performance in persons living with HIV remain poorly understood. This is the…
View article: Latinx brain health disparities in cognitive aging: The role of acculturation on brain integrity and cognition among older HIV+ adults
Latinx brain health disparities in cognitive aging: The role of acculturation on brain integrity and cognition among older HIV+ adults Open
Background The US Latinx population is the largest ethnoracial minority group and the fastest growing sector of the aging population (Escarce et al., 2006; US Census Bureau, 2008). Compared to non‐Latinx whites (NLW), the Latinx population…
View article: The neurocognitive effects of a past cannabis use disorder in a diverse sample of people living with HIV
The neurocognitive effects of a past cannabis use disorder in a diverse sample of people living with HIV Open
People living with HIV (PLWH) report higher rates of cannabis use than the general population, a trend likely to continue in light of recent policy changes and the reported therapeutic benefits of cannabis for PLWH. Therefore, it is import…
View article: White Matter Regions With Low Microstructure in Young Adults Spatially Coincide With White Matter Hyperintensities in Older Adults
White Matter Regions With Low Microstructure in Young Adults Spatially Coincide With White Matter Hyperintensities in Older Adults Open
Microstructural and macrostructural white matter damage occurs frequently with aging, is associated with negative health outcomes, and can be imaged non-invasively as fractional anisotropy (FA) and white matter hyperintensities (WMH), resp…
View article: White matter regions with low microstructure in young adults are associated with white matter hyperintensities in late life
White matter regions with low microstructure in young adults are associated with white matter hyperintensities in late life Open
Background White matter hyperintensities (WMH) are areas of increased signal observed on T2-weighted magnetic resonance imaging (MRI) that reflect macrostructural white matter damage frequently observed in aging. The extent to which dimini…
View article: Circulating inflammatory biomarkers are related to cerebrovascular disease in older adults
Circulating inflammatory biomarkers are related to cerebrovascular disease in older adults Open
Among older adults, increased circulating inflammatory biomarkers were associated with the presence of infarcts and microbleeds, WMH burden, and progression of WMH.
View article: Recessive Host Range Mutants and Unsusceptible Cells That Inactivate Virions without Genome Penetration: Ecological and Technical Implications
Recessive Host Range Mutants and Unsusceptible Cells That Inactivate Virions without Genome Penetration: Ecological and Technical Implications Open
To expand host range, viruses must interact with unsusceptible host cell surfaces, which could be detrimental. As observed in this study, virions were inactivated without genome penetration. This may be advantageous to potential new hosts,…
View article: Cerebrovascular Disease and Neurodegeneration in Alzheimer’s Disease with and without a Strong Family History: A Pilot Magnetic Resonance Imaging Study in Dominican Republic
Cerebrovascular Disease and Neurodegeneration in Alzheimer’s Disease with and without a Strong Family History: A Pilot Magnetic Resonance Imaging Study in Dominican Republic Open
The incidence and prevalence of Alzheimer's disease (AD) dementia are higher among Caribbean Hispanics than among non-Hispanic Whites. The causes of this health disparity remain elusive, partially because of the relative limited capacity f…
View article: Relation of Dysglycemia to Structural Brain Changes in a Multiethnic Elderly Cohort
Relation of Dysglycemia to Structural Brain Changes in a Multiethnic Elderly Cohort Open
Objectives Abnormally high glucose levels (dysglycemia) increase with age. Epidemiological studies suggest that dysglycemia is a risk factor for cognitive impairment but the underlying pathophysiological mechanisms remain unclear. The obje…
View article: Is residual memory variance a valid method for quantifying cognitive reserve? A longitudinal application
Is residual memory variance a valid method for quantifying cognitive reserve? A longitudinal application Open
View article: Cerebral autoregulation, beta amyloid, and white matter hyperintensities are interrelated
Cerebral autoregulation, beta amyloid, and white matter hyperintensities are interrelated Open