Vanessa M. McDonald
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View article: Clinical remission in severe asthma treated with biologics and macrolides: Definition, prevalence, associated factors, and future perspectives
Clinical remission in severe asthma treated with biologics and macrolides: Definition, prevalence, associated factors, and future perspectives Open
View article: Key priorities to prevent avoidable asthma hospitalisations: insights from end-users
Key priorities to prevent avoidable asthma hospitalisations: insights from end-users Open
Preventable asthma hospitalisations remain a major concern. Guided by end-user input, this study identifies 9 research priorities to help Asthma Australia halve hospitalisations by 2030 and improve life for people with asthma and their fam…
View article: Emerging Therapeutics in COPD: Mapping Innovation to Treatable Traits
Emerging Therapeutics in COPD: Mapping Innovation to Treatable Traits Open
Chronic Obstructive Pulmonary Disease (COPD) is a complex, heterogeneous condition characterized by diverse clinical phenotypes and underlying pathobiological mechanisms. Traditional “one-size-fits-all” management strategies have limited e…
View article: The value of treatable traits across the spectrum of adult asthma severity
The value of treatable traits across the spectrum of adult asthma severity Open
Asthma is a heterogeneous condition characterized by diverse clinical phenotypes and variable treatment responses, underscoring the limitations of the traditional "one-size-fits-all" stepwise management paradigm. The treatable traits (TTs)…
View article: Safety of the 6-min walk test in adults with severe asthma
Safety of the 6-min walk test in adults with severe asthma Open
The 6MWT is safe for adults with severe asthma when pre-bronchodilation is provided and SpO2 <85 % is used as a stopping criterion. Participants treated or not with mAb achieved comparable 6MWT distances.
View article: Acute effects of low dose bisoprolol on lung function and blood pressure in COPD patients
Acute effects of low dose bisoprolol on lung function and blood pressure in COPD patients Open
Background and Objective: Recent observational data suggests that cardioselective β-blockers like bisoprolol are safe and beneficial for patients with chronic obstructive pulmonary disease (COPD). However, the acute effects of bisoprolol o…
View article: User experience of air purifiers for the purpose of reducing acute respiratory tract infections: A cross-sectional survey in residential aged care settings
User experience of air purifiers for the purpose of reducing acute respiratory tract infections: A cross-sectional survey in residential aged care settings Open
The survey has provided evidence of participants' high level of acceptability of using air purifiers in residential aged care facilities and their positive experiences with air purifier use. This research has demonstrated that in-room air …
View article: Evaluation of the effect of multimorbidity on difficult-to-treat asthma using a novel score (MiDAS): a multinational study of asthma cohorts
Evaluation of the effect of multimorbidity on difficult-to-treat asthma using a novel score (MiDAS): a multinational study of asthma cohorts Open
UK National Institute for Health and Care Research, Australian National Health and Medical Research Council, Hunter Medical Research Institute, University of Newcastle (Australia), and John Hunter Hospital Charitable Trust.
View article: Treatable traits in cancer: expanding the paradigm to people with diagnosed malignancies
Treatable traits in cancer: expanding the paradigm to people with diagnosed malignancies Open
View article: Unlocking Asthma Remission: Key Insights From an Expert Roundtable Discussion
Unlocking Asthma Remission: Key Insights From an Expert Roundtable Discussion Open
Treatment targets in severe asthma have evolved towards a remission‐focused paradigm guided by precision medicine. This novel concept requires a shift from evaluating the efficacy of therapies based on a single outcome at a single time poi…
View article: A Global Achievement: Introducing the Inducible Laryngeal Dysfunction/Vocal Cord Dysfunction Toolkit—A Free Global, Peer‐Reviewed Clinical Resource
A Global Achievement: Introducing the Inducible Laryngeal Dysfunction/Vocal Cord Dysfunction Toolkit—A Free Global, Peer‐Reviewed Clinical Resource Open
View article: Engagement and outcomes of virtual antenatal asthma care: a randomised controlled tele-trial
Engagement and outcomes of virtual antenatal asthma care: a randomised controlled tele-trial Open
Background Access, availability and engagement of optimal asthma management are limited in maternity care. This study evaluated the engagement and outcomes of a virtual model of antenatal asthma care compared to a face-to-face model. Metho…
View article: Exercise Recommendations and Practical Considerations for Asthma Management—An EAACI Position Paper
Exercise Recommendations and Practical Considerations for Asthma Management—An EAACI Position Paper Open
Exercise is an important treatment for people with asthma and should be considered alongside pharmacological therapy when developing personalised asthma management plans. Despite this, there remains limited guidance concerning the practica…
View article: Patterns of care in the management of high-risk COPD in Australia (2015–2019): an observational study for the CONQUEST quality improvement program
Patterns of care in the management of high-risk COPD in Australia (2015–2019): an observational study for the CONQUEST quality improvement program Open
This study was conducted by Optimum Patient Care Australia Pty Ltd (OPCA) and was partially funded by OPCA and AstraZeneca Pty Ltd. No funding was received by the Observational & Pragmatic Research Institute Pte Ltd (OPRI) for its contribu…
View article: Breastfeeding outcomes and maternal asthma in the early postpartum period: an Australian population-based obstetric records analysis
Breastfeeding outcomes and maternal asthma in the early postpartum period: an Australian population-based obstetric records analysis Open
Maternal asthma increases the risk of adverse perinatal and respiratory outcomes in their infants (1) ; breastfeeding may mitigate the risk of respiratory outcomes, including wheeze (2,3) . However, breastfeeding rates are lower in women w…
View article: Dysfunctional Breathing and Depression Are Core Extrapulmonary and Behavior/Risk Factor Traits in Type 2–High Severe Asthma
Dysfunctional Breathing and Depression Are Core Extrapulmonary and Behavior/Risk Factor Traits in Type 2–High Severe Asthma Open
Core extrapulmonary and behavior/risk factor traits in T2-high severe asthma were dysfunctional breathing and depression, contributing to worse asthma outcomes, suggesting that core TTs may differ between asthma inflammatory phenotypes. El…
View article: Treatable Trait Guided Asthma Management: A Feasibility Study
Treatable Trait Guided Asthma Management: A Feasibility Study Open
Background and Objectives Treatable trait‐based personalised medicine improves outcomes in severe asthma clinics. We assessed the feasibility of a randomised controlled trial (RCT) of protocolised treatable trait‐guided asthma management i…
View article: Social determinants of mental health in asthma: an exploratory study
Social determinants of mental health in asthma: an exploratory study Open
Introduction Asthma and mental health problems co-occur at high rates. In context of a holistic approach to health, considering the extent to which social determinants relate to mental health in people with asthma helps identify health ine…
View article: Experiences of Oral Corticosteroid Use and Adverse Effects: A National Cross-Sectional Survey of People with Asthma
Experiences of Oral Corticosteroid Use and Adverse Effects: A National Cross-Sectional Survey of People with Asthma Open
Adverse effects of OCS use are common. People with asthma are not adequately informed about optimal OCS use or strategies to reduce overuse. These findings can help guide the implementation of OCS stewardship initiatives.
View article: Correction: Credentialed pharmacist-led home medicines reviews targeting treatable traits and their impact on health outcomes in people with chronic obstructive pulmonary disease: a pre- and post-intervention study
Correction: Credentialed pharmacist-led home medicines reviews targeting treatable traits and their impact on health outcomes in people with chronic obstructive pulmonary disease: a pre- and post-intervention study Open
View article: Air Purifiers and Acute Respiratory Infections in Residential Aged Care
Air Purifiers and Acute Respiratory Infections in Residential Aged Care Open
Importance The effectiveness of in-room air purification for the reduction of acute respiratory infections (ARIs) in residential aged-care facilities (RACFs) is unknown. Objective To investigate the effectiveness of in-room air purifiers w…
View article: Perceptions of sedentary behaviour in people with severe asthma: a qualitative study
Perceptions of sedentary behaviour in people with severe asthma: a qualitative study Open
People with severe asthma often lead sedentary lifestyles, which adversely affects overall health and asthma-specific outcomes. To inform future sedentary behaviour- interventions, this study aimed to explore perceptions of sedentary behav…
View article: Credentialed pharmacist-led home medicines reviews targeting treatable traits and their impact on health outcomes in people with chronic obstructive pulmonary disease: a pre- and post-intervention study
Credentialed pharmacist-led home medicines reviews targeting treatable traits and their impact on health outcomes in people with chronic obstructive pulmonary disease: a pre- and post-intervention study Open
Background Patients with chronic obstructive pulmonary disease (COPD) should engage in self-management strategies targeting behavioural traits and lifestyle risk-factors for optimal outcomes. Aim To evaluate the impact of credentialed phar…
View article: Targeted DNase treatment of obstructive lung disease: a pilot randomised controlled trial
Targeted DNase treatment of obstructive lung disease: a pilot randomised controlled trial Open
Background Sputum extracellular DNA (eDNA) is associated with disease severity in asthma and COPD and therefore emerging as a potential therapeutic target. The aim of this study was to investigate the effect of 10 days of recombinant human…
View article: Integrating hot topics and implementation of treatable traits in asthma
Integrating hot topics and implementation of treatable traits in asthma Open
People with asthma experience many different problems related to their illness. The number and type of problems differ between patients. This results in asthma being a complex and heterogeneous disorder which mandates a personalised approa…
View article: Credentialed pharmacist-led home medicines reviews targeting treatable traits and their impact on health outcomes in people with COPD
Credentialed pharmacist-led home medicines reviews targeting treatable traits and their impact on health outcomes in people with COPD Open
Background Patients with COPD should engage in self-management strategies targeting behavioural traits and lifestyle risk factors for optimal outcomes. Aim To evaluate the impact of credentialed pharmacist-led home medicines review (HMR) t…
View article: Study protocol: perinatal mood treatment study
Study protocol: perinatal mood treatment study Open
Perinatal depression (PND) affects up to 20% of women and is associated with significant impairment and disability in affected women. In addition, perinatal depression is associated with broader public health and multigenerational conseque…
View article: Understanding Breathlessness Burden and Psychophysiological Correlates in Asthma
Understanding Breathlessness Burden and Psychophysiological Correlates in Asthma Open
Over half of people with severe asthma experience physically limiting breathlessness despite treatment. Targeting psychophysiological factors, or traits, associated with breathlessness may help relieve this distressing symptom, which is of…
View article: Perceptions of sedentary behaviour in people with severe asthma: A qualitative study
Perceptions of sedentary behaviour in people with severe asthma: A qualitative study Open
People with severe asthma often lead sedentary lifestyles, which adversely affects overall health and asthma-specific outcomes. To inform future sedentary behaviour- interventions, this study aimed to explore perceptions of sedentary behav…
View article: Treatable traits—Where we are, where we are headed
Treatable traits—Where we are, where we are headed Open
For close to a decade now treatable traits has been part of the respiratory community vernacular. Since the approach was proposed as a personalized medicine strategy for treating people with airway diseases, there has been a flurry of revi…