Vanessa Marchant
YOU?
Author Swipe
View article: Troxerutin is a novel osmotic agent for peritoneal dialysis with protective cardiovascular actions
Troxerutin is a novel osmotic agent for peritoneal dialysis with protective cardiovascular actions Open
Background and hypothesis End-stage renal disease patients require peritoneal dialysis (PD) as a life-saving therapy; however, they continue to experience systemic inflammation and increased cardiovascular pathology. These complications ca…
View article: <scp>STING</scp> inhibition alleviates experimental peritoneal damage: potential therapeutic relevance for peritoneal dialysis
<span>STING</span> inhibition alleviates experimental peritoneal damage: potential therapeutic relevance for peritoneal dialysis Open
Peritoneal dialysis (PD) is a widely used kidney replacement therapy for patients with end‐stage kidney disease. Nevertheless, long‐term exposure to PD fluid can damage the peritoneal membrane, leading to ultrafiltration failure and, ultim…
View article: The Role of miR-802 in Diabetic Kidney Disease: Diagnostic and Therapeutic Insights
The Role of miR-802 in Diabetic Kidney Disease: Diagnostic and Therapeutic Insights Open
Diabetic kidney disease (DKD) is a serious microvascular complication of diabetes mellitus and a leading cause of end-stage kidney disease. Despite its rising incidence, awareness and early detection of renal complications remain limited. …
View article: Dasatinib and Quercetin Combination Increased Kidney Damage in Acute Folic Acid-Induced Experimental Nephropathy
Dasatinib and Quercetin Combination Increased Kidney Damage in Acute Folic Acid-Induced Experimental Nephropathy Open
Background/Objectives: Acute kidney injury (AKI) remains an unsolved medical problem due to the lack of effective treatments, high mortality, and increased susceptibility to progression to chronic kidney disease (CKD), especially in the el…
View article: CCN2 Activates Cellular Senescence Leading to Kidney Fibrosis in Folic Acid-Induced Experimental Nephropathy
CCN2 Activates Cellular Senescence Leading to Kidney Fibrosis in Folic Acid-Induced Experimental Nephropathy Open
Cellular communication network factor 2 (CCN2, also known as CTGF) is a complex protein that regulates numerous cellular functions. This biomolecule exhibits dual functions, depending on the context, and can act as a matricellular protein …
View article: Dasatinib and Quercetin Treatment Increased Kidney Damage in Acute Folic Acid-Induced Experimental Nephropathy
Dasatinib and Quercetin Treatment Increased Kidney Damage in Acute Folic Acid-Induced Experimental Nephropathy Open
Background/Objectives: Acute kidney injury (AKI) remains an unsolved medical problem due to the lack of effective treatments, high mortality and increased susceptibility to progression to chronic kidney disease (CKD), especially in the eld…
View article: Targeting STING in experimental peritoneal damage: a novel approach in peritoneal dialysis therapy
Targeting STING in experimental peritoneal damage: a novel approach in peritoneal dialysis therapy Open
Peritoneal dialysis (PD) is a widely used kidney replacement therapy for end-stage kidney disease (ESKD) patients. However, long-term exposure to PD fluids (PDF) can lead to peritoneal membrane (PM) damage, causing ultrafiltration failure …
View article: Ccn2 Deletion Reduces Cardiac Dysfunction, Oxidative Markers, and Fibrosis Induced by Doxorubicin Administration in Mice
Ccn2 Deletion Reduces Cardiac Dysfunction, Oxidative Markers, and Fibrosis Induced by Doxorubicin Administration in Mice Open
Cellular Communication Network Factor 2 (CCN2) is a matricellular protein implicated in cell communication and microenvironmental signaling. Overexpression of CCN2 has been documented in various cardiovascular pathologies, wherein it may e…
View article: Mechanisms of mesothelial cell response to viral infections: HDAC1-3 inhibition blocks poly(I:C)-induced type I interferon response and modulates the mesenchymal/inflammatory phenotype
Mechanisms of mesothelial cell response to viral infections: HDAC1-3 inhibition blocks poly(I:C)-induced type I interferon response and modulates the mesenchymal/inflammatory phenotype Open
Infectious peritonitis is a leading cause of peritoneal functional impairment and a primary factor for therapy discontinuation in peritoneal dialysis (PD) patients. Although bacterial infections are a common cause of peritonitis episodes, …
View article: BET Protein Inhibitor JQ1 Ameliorates Experimental Peritoneal Damage by Inhibition of Inflammation and Oxidative Stress
BET Protein Inhibitor JQ1 Ameliorates Experimental Peritoneal Damage by Inhibition of Inflammation and Oxidative Stress Open
Peritoneal dialysis (PD) is a current replacement therapy for end-stage kidney diseases (ESKDs). However, long-term exposure to PD fluids may lead to damage of the peritoneal membrane (PM) through mechanisms involving the activation of the…
View article: #3065 INVESTIGATION OF NOTCH PATHWAY ACTIVATION AND ITS RELATION TO GREMLIN IN AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY DISEASE
#3065 INVESTIGATION OF NOTCH PATHWAY ACTIVATION AND ITS RELATION TO GREMLIN IN AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY DISEASE Open
Background and Aims Activation of the NOTCH signalling pathway has been described in several progressive kidney diseases. Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a genetic disease caused by PKD1 or PKD2 mutations, which cod…
View article: #3612 STING IS INVOLVED IN THE CELLULAR SENESCENCE PROCESS ASSOCIATED WITH RENAL AGING
#3612 STING IS INVOLVED IN THE CELLULAR SENESCENCE PROCESS ASSOCIATED WITH RENAL AGING Open
Background and Aims Cellular senescence is an adaptative process in response to damage or stress. It consists of a cell-cycle-arrest (CCA) alternatively to the programmed cell death process, which is necessary for the regeneration of damag…
View article: #4673 POLY(I:C) INDUCES MORPHOLOGICAL CHANGES AND TYPE I INTERFERON-MEDIATED INFLAMMATORY RESPONSE IN MESOTHELIAL CELLS FROM PERITONEUM
#4673 POLY(I:C) INDUCES MORPHOLOGICAL CHANGES AND TYPE I INTERFERON-MEDIATED INFLAMMATORY RESPONSE IN MESOTHELIAL CELLS FROM PERITONEUM Open
Background and Aims Peritonitis is a major cause of morbidity and discontinuation of the therapy in peritoneal dialysis (PD) patients. Most of peritonitis episodes during PD may be imputed to bacterial infection, although in about 20% of t…
View article: #5865 BET INHIBITION DIMINISHES CELLULAR SENESCENCE IN CULTURED TUBULAR EPITHELIAL CELLS
#5865 BET INHIBITION DIMINISHES CELLULAR SENESCENCE IN CULTURED TUBULAR EPITHELIAL CELLS Open
Background and Aims Chronic kidney disease (CKD) can be considered an age-related disorder. Recent studies have shown the involvement of the activation of cellular senescence mechanisms in the kidney and aging. Intensive research to develo…
View article: Novel Aspects of the Immune Response Involved in the Peritoneal Damage in Chronic Kidney Disease Patients under Dialysis
Novel Aspects of the Immune Response Involved in the Peritoneal Damage in Chronic Kidney Disease Patients under Dialysis Open
Chronic kidney disease (CKD) incidence is growing worldwide, with a significant percentage of CKD patients reaching end-stage renal disease (ESRD) and requiring kidney replacement therapies (KRT). Peritoneal dialysis (PD) is a convenient K…
View article: Type IV Collagen and SOX9 Are Molecular Targets of BET Inhibition in Experimental Glomerulosclerosis
Type IV Collagen and SOX9 Are Molecular Targets of BET Inhibition in Experimental Glomerulosclerosis Open
Progressive glomerulonephritis (GN) is characterized by an excessive accumulation of extracellular (ECM) proteins, mainly type IV collagen (COLIV), in the glomerulus leading to glomerulosclerosis. The current therapeutic approach to GN is …
View article: Kidney microRNA Expression Pattern in Type 2 Diabetic Nephropathy in BTBR Ob/Ob Mice
Kidney microRNA Expression Pattern in Type 2 Diabetic Nephropathy in BTBR Ob/Ob Mice Open
Diabetic nephropathy (DN) is the main leading cause of chronic kidney disease worldwide. Although remarkable therapeutic advances have been made during the last few years, there still exists a high residual risk of disease progression to e…
View article: CCN2 Binds to Tubular Epithelial Cells in the Kidney
CCN2 Binds to Tubular Epithelial Cells in the Kidney Open
Cellular communication network-2 (CCN2), also called connective tissue growth factor (CTGF), is considered a fibrotic biomarker and has been suggested as a potential therapeutic target for kidney pathologies. CCN2 is a matricellular protei…
View article: Oxidative Stress and Cellular Senescence Are Involved in the Aging Kidney
Oxidative Stress and Cellular Senescence Are Involved in the Aging Kidney Open
Chronic kidney disease (CKD) can be considered as a clinical model for premature aging. However, non-invasive biomarkers to detect early kidney damage and the onset of a senescent phenotype are lacking. Most of the preclinical senescence s…
View article: Epigenetic Modulation of Gremlin-1/NOTCH Pathway in Experimental Crescentic Immune-Mediated Glomerulonephritis
Epigenetic Modulation of Gremlin-1/NOTCH Pathway in Experimental Crescentic Immune-Mediated Glomerulonephritis Open
Crescentic glomerulonephritis is a devastating autoimmune disease that without early and properly treatment may rapidly progress to end-stage renal disease and death. Current immunosuppressive treatment provides limited efficacy and an imp…
View article: Epigenetic Modulation of Gremlin-1/NOTCH Pathway in Experimental Crescentic Immune-Mediated Glomerulonephritis
Epigenetic Modulation of Gremlin-1/NOTCH Pathway in Experimental Crescentic Immune-Mediated Glomerulonephritis Open
Crescentic glomerulonephritis is a devastating autoimmune disease that without early and properly treat-ment may rapidly progress to end-stage renal disease and death. Current immunosuppressive treatment provided limited efficacy and an im…
View article: Epigenetic Modulation of Gremlin-1/NOTCH Pathway in Experimental Crescentic Immune-Mediated Glomerulonephritis
Epigenetic Modulation of Gremlin-1/NOTCH Pathway in Experimental Crescentic Immune-Mediated Glomerulonephritis Open
Crescentic glomerulonephritis is a devastating autoimmune disease that without early and properly treat-ment may rapidly progress to end-stage renal disease and death. Current immunosuppressive treatment provided limited efficacy and an im…
View article: Epigenetic Modulation of Gremlin-1/NOTCH Pathway in Experimental Crescentic Immune-Mediated Glomerulonephritis
Epigenetic Modulation of Gremlin-1/NOTCH Pathway in Experimental Crescentic Immune-Mediated Glomerulonephritis Open
Crescentic glomerulonephritis is a devastating autoimmune disease that without early and properly treat-ment may rapidly progress to end-stage renal disease and death. Current immunosuppressive treatment provided limited efficacy and an im…
View article: RICORS2040: the need for collaborative research in chronic kidney disease
RICORS2040: the need for collaborative research in chronic kidney disease Open
Chronic kidney disease (CKD) is a silent and poorly known killer. The current concept of CKD is relatively young and uptake by the public, physicians and health authorities is not widespread. Physicians still confuse CKD with chronic kidne…
View article: Role of Macrophages and Related Cytokines in Kidney Disease
Role of Macrophages and Related Cytokines in Kidney Disease Open
Inflammation is a key characteristic of kidney disease, but this immune response is two-faced. In the acute phase of kidney injury, there is an activation of the immune cells to fight against the insult, contributing to kidney repair and r…
View article: Acute Kidney Injury is Aggravated in Aged Mice by the Exacerbation of Proinflammatory Processes
Acute Kidney Injury is Aggravated in Aged Mice by the Exacerbation of Proinflammatory Processes Open
Acute kidney injury (AKI) is more frequent in elderly patients. Mechanisms contributing to AKI (tubular cell death, inflammatory cell infiltration, impaired mitochondrial function, and prolonged cell-cycle arrest) have been linked to cellu…
View article: MO338INCREASED INFLAMMATORY RESPONSE IS A HALLMARK OF AGE-RELATED AGGRAVATION OF EXPERIMENTAL AKI
MO338INCREASED INFLAMMATORY RESPONSE IS A HALLMARK OF AGE-RELATED AGGRAVATION OF EXPERIMENTAL AKI Open
Background and Aims Acute kidney injury (AKI) is associated with elevated mortality and morbidity presenting higher frequency in aged patients. Different mechanisms are activated in AKI, including tubular epithelial cell death (apoptosis a…
View article: IL-17A as a Potential Therapeutic Target for Patients on Peritoneal Dialysis
IL-17A as a Potential Therapeutic Target for Patients on Peritoneal Dialysis Open
Chronic kidney disease (CKD) is a health problem reaching epidemic proportions. There is no cure for CKD, and patients may progress to end-stage renal disease (ESRD). Peritoneal dialysis (PD) is a current replacement therapy option for ESR…
View article: Statins: Could an old friend help in the fight against COVID‐19?
Statins: Could an old friend help in the fight against COVID‐19? Open
The COVID‐19 pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has overwhelmed healthcare systems requiring the rapid development of treatments, at least, to reduce COVID‐19 severity. Drug repurposing offe…
View article: Statins: Could an old friend help the fight against COVID-19?
Statins: Could an old friend help the fight against COVID-19? Open
COVID-19 pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has overwhelmed Healthcare Systems requiring the rapid development of treatments, at least, to reduce COVID-19 severity. Drug repurposing offers a…