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View article: Indian clinical practice consensus guidelines for the management of locoregional laryngeal cancer – Update 2024
Indian clinical practice consensus guidelines for the management of locoregional laryngeal cancer – Update 2024 Open
Laryngeal cancer typically presents at an early stage, and most patients are treated with curative intent. Due to the functional and cosmetic morbidities associated with surgical approaches, nonsurgical modalities are increasingly favored.…
View article: Triple Oral Metronomic Chemotherapy Versus Chemotherapy of Physician Discretion After Failure of Platinum-Based Therapy in Advanced Head and Neck Cancer: A Phase III Randomized Study (METRO-CHASE Study)
Triple Oral Metronomic Chemotherapy Versus Chemotherapy of Physician Discretion After Failure of Platinum-Based Therapy in Advanced Head and Neck Cancer: A Phase III Randomized Study (METRO-CHASE Study) Open
PURPOSE Platinum-refractory advanced head and neck squamous cell carcinoma (HNSCC) has poor outcomes and limited treatment options, especially in resource-constrained settings. Triple oral metronomic chemotherapy (OMCT), involving low-dose…
View article: Indian clinical practice consensus guidelines for the management of oral cavity cancer – Update 2024
Indian clinical practice consensus guidelines for the management of oral cavity cancer – Update 2024 Open
Squamous cell carcinoma is the predominant cancer of the oral cavity. Oral cavity cancer (OCC) typically presents at an early stage. Almost all patients are treated with curative intent. Surgical approaches are the mainstay of treatment, a…
View article: Excellence in oncology care (EIOC) consensus guidelines on integrating immunotherapy (IO) in resectable non-small cell lung cancer (NSCLC) for the Middle East and Indian subcontinent
Excellence in oncology care (EIOC) consensus guidelines on integrating immunotherapy (IO) in resectable non-small cell lung cancer (NSCLC) for the Middle East and Indian subcontinent Open
The Excellence in Oncology Care (EIOC) 2023 Congress, held in Dubai, took place both in person and online. This annual event brought together oncologists from across the Middle East and the Indian subcontinent. A panel of 17 regional exper…
View article: Indian clinical practice consensus guidelines for the management of locoregional hypopharyngeal cancer – Update 2024
Indian clinical practice consensus guidelines for the management of locoregional hypopharyngeal cancer – Update 2024 Open
Hypopharyngeal cancer usually presents at the locally advanced stage and is relatively uncommon. Early diagnosis is difficult because of recesses and spaces around the larynx, which delay presentation until local progression or neck metast…
View article: The landscape of conventional and artificial intelligence-based clinical prediction models in non-small-cell lung cancer: from development to real-world validation
The landscape of conventional and artificial intelligence-based clinical prediction models in non-small-cell lung cancer: from development to real-world validation Open
Globally, lung cancer remains the most common cause of cancer mortality, with non-small-cell lung cancer (NSCLC) being the most common subtype of lung cancer diagnosed. This review paper provides a comprehensive landscape of clinical predi…
View article: Geriatric Assessment: ASCO Global Guideline
Geriatric Assessment: ASCO Global Guideline Open
ASCO Guidelines provide recommendations with comprehensive review and analyses of the relevant literature for each recommendation, following the guideline development process as outlined in the ASCO Guidelines Methodology Manual , ASCO Gui…
View article: Vascular endothelial growth factor: A potential prognosticator in Ewing sarcoma
Vascular endothelial growth factor: A potential prognosticator in Ewing sarcoma Open
Background: Vascular endothelial growth factor (VEGF) is an angiogenic marker and is implicated in the carcinogenesis and prognostication of cancers. However, its prognostic potential in Ewing sarcoma (ES) merits exploration. Methods: Hist…
View article: Comprehensive Genomic Profiling of Indian Patients With Lung Cancer
Comprehensive Genomic Profiling of Indian Patients With Lung Cancer Open
PURPOSE Genomic profiling has revolutionized non–small cell lung cancer (NSCLC) therapy, but molecular data on Indian patients with NSCLC are limited. MATERIALS AND METHODS We analyzed next-generation sequencing (NGS) data of 5,219 Indian …
View article: Genomic Characterization of Papillary Thyroid Cancer Reveals Germline Mutations Associated With Congenital Hypothyroidism
Genomic Characterization of Papillary Thyroid Cancer Reveals Germline Mutations Associated With Congenital Hypothyroidism Open
PURPOSE Thyroid dyshormonogenesis, a form of congenital hypothyroidism, is characterized by defects in thyroid hormone synthesis genes, affecting both children and adults. However, the potential link between such genetic defects and the de…
View article: Safety and Efficacy of Alectinib in the First Line for ALK-Mutated Lung Cancer: A Real-World Data from India
Safety and Efficacy of Alectinib in the First Line for ALK-Mutated Lung Cancer: A Real-World Data from India Open
Advanced/metastatic ALK-mutated lung cancer has excellent long-term survival due availability of multiple targeted drugs. Alectinib is one of the preferred first-line therapies based on the Alex trial data. We present a real-world outcome …
View article: Imaging-based skeletal muscle quality and clinical outcomes in Indian older patients with cancer: A retrospective analysis
Imaging-based skeletal muscle quality and clinical outcomes in Indian older patients with cancer: A retrospective analysis Open
Objectives: Computer tomography (CT) measurements of cross-sectional area and density reflect muscle performance and function, but their use is limited in practice. We aimed to evaluate the association of CT-based skeletal muscle quality (…
View article: Patterns of Failure in Head and Neck Carcinoma of Unknown Primary: Insights from a Tobacco-Associated Cancer Cohort
Patterns of Failure in Head and Neck Carcinoma of Unknown Primary: Insights from a Tobacco-Associated Cancer Cohort Open
We report the patterns of failure and survival with carcinoma of unknown primary of the head and neck (CUP-HN). This is a retrospective audit of CUP-HN patients treated with curative radiotherapy (RT) between January 2006 and December 2020…
View article: Comparison of PSA Response to Generic Versus Innovator (Zytiga) Formulations of Abiraterone in Metastatic CRPC: A Retrospective Analysis
Comparison of PSA Response to Generic Versus Innovator (Zytiga) Formulations of Abiraterone in Metastatic CRPC: A Retrospective Analysis Open
Introduction Abiraterone acetate has been shown to enhance overall survival and radiographic progression-free survival (rPFS) in men with metastatic castration-resistant prostate cancer (mCRPC). Presently, multiple generic brands of abirat…
View article: A novel machine learning-based cancer-specific cardiovascular disease risk score among patients with breast, colorectal, or lung cancer
A novel machine learning-based cancer-specific cardiovascular disease risk score among patients with breast, colorectal, or lung cancer Open
Background Cancer patients have up to a 3-fold higher risk for cardiovascular disease (CVD) than the general population. Traditional CVD risk scores may be less accurate for them. We aimed to develop cancer-specific CVD risk scores and com…
View article: Safety of nivolumab in treating Indian patients with non-small-cell lung carcinoma and renal cell carcinoma: A prospective multicenter study
Safety of nivolumab in treating Indian patients with non-small-cell lung carcinoma and renal cell carcinoma: A prospective multicenter study Open
Background: Nivolumab has shown significant therapeutic benefits in treating non-small-cell lung carcinoma (NSCLC) and renal cell carcinoma (RCC). Objectives: The primary objective of the study was to assess safety and tolerability of nivo…
View article: Prevalence of <i>EGFR</i> Mutations in Patients With Resected Stage I to III Nonsquamous Non–Small Cell Lung Cancer: Results of India Cohort
Prevalence of <i>EGFR</i> Mutations in Patients With Resected Stage I to III Nonsquamous Non–Small Cell Lung Cancer: Results of India Cohort Open
PURPOSE The spectrum of EGFR is inadequately researched in patients with early-stage non–small cell lung cancer (NSCLC) in India. EARLY-epidermal growth factor receptor (EGFR) India (ClinicalTrials.gov identifier: NCT04742192 ), as part of…
View article: Imaging patterns and recommendations for diagnosis, staging, and management of lung cancer
Imaging patterns and recommendations for diagnosis, staging, and management of lung cancer Open
Lung cancer is the second most commonly diagnosed cancer worldwide. In the present era of targeted therapy for various lung cancer mutations, it is essential to be aware of the imaging correlates of various lung cancer mutations on contras…
View article: Pan-Asian adapted ESMO Clinical Practice Guidelines for the diagnosis, treatment and follow-up of patients with oncogene-addicted metastatic non-small-cell lung cancer
Pan-Asian adapted ESMO Clinical Practice Guidelines for the diagnosis, treatment and follow-up of patients with oncogene-addicted metastatic non-small-cell lung cancer Open
The European Society for Medical Oncology (ESMO) Clinical Practice Guidelines for the diagnosis, treatment and follow-up of patients with oncogene-addicted metastatic non-small-cell lung cancer (mNSCLC), published in January 2023, was modi…
View article: Indian clinical practice consensus guidelines for the management of locoregional hypopharyngeal cancer - Update 2023
Indian clinical practice consensus guidelines for the management of locoregional hypopharyngeal cancer - Update 2023 Open
Hypopharyngeal cancer usually presents at a locally advanced stage. Almost all patients are treated with a curative intent. As surgical approaches are functionally and cosmetically morbid, nonsurgical modalities are preferred. This review …
View article: Efficacy and Safety of Biosimilar Cetuximab Versus Innovator Cetuximab in Indian Patients With Head and Neck Cancer: A Multicenter, Randomized, Double-Blind, Phase III Trial
Efficacy and Safety of Biosimilar Cetuximab Versus Innovator Cetuximab in Indian Patients With Head and Neck Cancer: A Multicenter, Randomized, Double-Blind, Phase III Trial Open
PURPOSE Squamous cell carcinoma of the head and neck (SCCHN) is the sixth most common cancer, with approximately 225,419 new cases with over 125,000 deaths annually in India. This trial compared the efficacy and safety of biosimilar cetuxi…
View article: Indian clinical practice consensus guidelines for the management of oropharyngeal cancer - Update 2023
Indian clinical practice consensus guidelines for the management of oropharyngeal cancer - Update 2023 Open
Oropharyngeal cancer typically presents at a nonmetastatic stage and is primarily treated with curative intent. While surgical options are available, they are often associated with significant functional and cosmetic morbidity, leading to …