Varina L. Boerwinkle
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View article: Multimodal contrastive learning on rs-fMRI to quantify whole-brain network recovery after hypothalamic hamartoma surgery
Multimodal contrastive learning on rs-fMRI to quantify whole-brain network recovery after hypothalamic hamartoma surgery Open
View article: Interpretable Transformer Models for rs-fMRI Epilepsy Classification and Biomarker Discovery
Interpretable Transformer Models for rs-fMRI Epilepsy Classification and Biomarker Discovery Open
Background Automated interpretation of resting-state fMRI (rs-fMRI) for epilepsy diagnosis remains a challenge. We developed a regularized transformer that models parcel-wise spatial patterns and long-range temporal dynamics to classify ep…
View article: Precision Connectivity in Arthritis Pain with Permutation and Network Analysis: A Key Step Toward Clinical Application
Precision Connectivity in Arthritis Pain with Permutation and Network Analysis: A Key Step Toward Clinical Application Open
Objective This study seeks to identify brain regions with atypical neural connectivity in individuals suffering from arthritis-related chronic pain, compared to healthy controls, using resting-state functional magnetic resonance imaging (r…
View article: Eigenvector biomarker for prediction of epileptogenic zones and surgical success from interictal data
Eigenvector biomarker for prediction of epileptogenic zones and surgical success from interictal data Open
Introduction: More than 50 million people worldwide suffer from epilepsy. Approximately 30% of epileptic patients suffer from medically refractory epilepsy (MRE), which means that over 15 million people must seek extensive treatment. One s…
View article: Combining interictal intracranial EEG and fMRI to compute a dynamic resting-state index for surgical outcome validation
Combining interictal intracranial EEG and fMRI to compute a dynamic resting-state index for surgical outcome validation Open
Introduction Accurate localization of the seizure onset zone (SOZ) is critical for successful epilepsy surgery but remains challenging with current techniques. We developed a novel seizure onset network characterization tool that combines …
View article: Change in Resting-State functional MRI Connectivity to Measure Individual Response to Epilepsy Surgery
Change in Resting-State functional MRI Connectivity to Measure Individual Response to Epilepsy Surgery Open
Objective This study evaluates fractional power spectrum contribution (fPSC), a biomarker derived from resting-state functional MRI (rs-fMRI), as an indicator of epileptogenic network activity in drug-resistant epilepsy (DRE) patients unde…
View article: Resting-state fMRI seizure onset localization meta-analysis: comparing rs-fMRI to other modalities including surgical outcomes
Resting-state fMRI seizure onset localization meta-analysis: comparing rs-fMRI to other modalities including surgical outcomes Open
Resting-state functional MRI (rs-fMRI) may localize the seizure onset zone (SOZ) for epilepsy surgery, when compared to intracranial EEG and surgical outcomes, per a prior meta-analysis. Our goals were to further characterize this agreemen…
View article: Resting-state fMRI seizure onset localization meta-analysis: comparing rs-fMRI to other modalities including surgical outcomes
Resting-state fMRI seizure onset localization meta-analysis: comparing rs-fMRI to other modalities including surgical outcomes Open
Objective Resting-state functional MRI (rs-fMRI) may localize the seizure onset zone (SOZ) for epilepsy surgery, when compared to intracranial EEG and surgical outcomes, per a prior meta-analysis. Our goals were to further characterize thi…
View article: Caring for Coma after Severe Brain Injury: Clinical Practices and Challenges to Improve Outcomes: An Initiative by the Curing Coma Campaign
Caring for Coma after Severe Brain Injury: Clinical Practices and Challenges to Improve Outcomes: An Initiative by the Curing Coma Campaign Open
View article: Correction: Common Data Elements for Disorders of Consciousness: Recommendations from the Working Group on Goals-of-Care and Family/Surrogate Decision-Maker Data
Correction: Common Data Elements for Disorders of Consciousness: Recommendations from the Working Group on Goals-of-Care and Family/Surrogate Decision-Maker Data Open
View article: Correction: Common Data Elements for Disorders of Consciousness: Recommendations from the Working Group on Neuroimaging
Correction: Common Data Elements for Disorders of Consciousness: Recommendations from the Working Group on Neuroimaging Open
The list of Curing Coma Campaign Collaborators included in the Acknowledgements section has been updated. Flora Hammond, Raimund Helbok, and Naomi Niznick have been added to the list. Several spelling errors have been corrected. A revised …
View article: Pre- and post-therapy functional MRI connectivity in severe acute brain injury with suppression of consciousness: a comparative analysis to epilepsy features
Pre- and post-therapy functional MRI connectivity in severe acute brain injury with suppression of consciousness: a comparative analysis to epilepsy features Open
Severe acute brain injury (SABI) with suppressed consciousness is a major societal burden, with early prognosis being crucial for life-and-death treatment decisions. Resting-state functional MRI (rs-fMRI) is promising for prognosis and ide…
View article: Correction: Common Data Elements for Disorders of Consciousness: Recommendations from the Working Group in the Pediatric Population
Correction: Common Data Elements for Disorders of Consciousness: Recommendations from the Working Group in the Pediatric Population Open
View article: Correction: Common Data Elements for Disorders of Consciousness: Recommendations from the Working Group on Physiology and Big Data
Correction: Common Data Elements for Disorders of Consciousness: Recommendations from the Working Group on Physiology and Big Data Open
View article: Correction: Common Data Elements for Disorders of Consciousness: Recommendations from the Electrophysiology Working Group
Correction: Common Data Elements for Disorders of Consciousness: Recommendations from the Electrophysiology Working Group Open
View article: Correction: Common Data Elements for Disorders of Consciousness: Recommendations from the Working Group on Hospital Course, Confounders, and Medications
Correction: Common Data Elements for Disorders of Consciousness: Recommendations from the Working Group on Hospital Course, Confounders, and Medications Open
View article: Virtual stimulation of the interictal EEG network localizes the EZ as a measure of cortical excitability
Virtual stimulation of the interictal EEG network localizes the EZ as a measure of cortical excitability Open
Introduction: For patients with drug-resistant epilepsy, successful localization and surgical treatment of the epileptogenic zone (EZ) can bring seizure freedom. However, surgical success rates vary widely because there are currently no cl…
View article: Common Data Elements for Disorders of Consciousness: Recommendations from the Working Group on Outcomes and Endpoints
Common Data Elements for Disorders of Consciousness: Recommendations from the Working Group on Outcomes and Endpoints Open
The DoC outcome and endpoint CDEs are a starting point in the broader effort to standardize outcome evaluation of persons with DoC. The ultimate goal is to harmonize DoC studies and allow for more precise assessment of outcomes after sever…
View article: Opioid neurotoxicity: A case series and review from members of the Child Neurology Society Neurocritical Care Special Interest Group
Opioid neurotoxicity: A case series and review from members of the Child Neurology Society Neurocritical Care Special Interest Group Open
Objective The Child Neurology Society 2023 Annual Meeting Neurocritical Care Special Interest Group discussed pediatric opioid use–associated neurotoxicity with cerebellar edema (POUNCE). Inspired by the discussion and the suspicion of an …
View article: Motor network dynamic resting state fMRI connectivity of neurotypical children in regions affected by cerebral palsy
Motor network dynamic resting state fMRI connectivity of neurotypical children in regions affected by cerebral palsy Open
Background Normative childhood motor network resting-state fMRI effective connectivity is undefined, yet necessary for translatable dynamic resting-state-network-informed evaluation in pediatric cerebral palsy. Methods Cross-spectral dynam…
View article: Diffusion and functional MRI in surgical neuromodulation
Diffusion and functional MRI in surgical neuromodulation Open
Surgical neuromodulation has witnessed significant progress in recent decades. Notably, deep brain stimulation (DBS), delivered precisely within therapeutic targets, has revolutionized the treatment of medication-refractory movement disord…
View article: Diffusion and functional MRI in surgical neuromodulation
Diffusion and functional MRI in surgical neuromodulation Open
View article: The expert's knowledge combined with AI outperforms AI alone in seizure onset zone localization using resting state fMRI
The expert's knowledge combined with AI outperforms AI alone in seizure onset zone localization using resting state fMRI Open
We evaluated whether integration of expert guidance on seizure onset zone (SOZ) identification from resting state functional MRI (rs-fMRI) connectomics combined with deep learning (DL) techniques enhances the SOZ delineation in patients wi…
View article: Pre- and post-therapy functional MRI connectivity in severe acute brain injury with suppression of consciousness: a comparative analysis to epilepsy features
Pre- and post-therapy functional MRI connectivity in severe acute brain injury with suppression of consciousness: a comparative analysis to epilepsy features Open
Severe acute brain injury (SABI) with suppressed consciousness is a major societal burden, with early prognosis being crucial for life-and-death treatment decisions. Resting-state functional MRI (rs-fMRI) is promising for prognosis and ide…
View article: Motor network dynamic resting state fMRI connectivity of neurotypical children in regions affected by cerebral palsy
Motor network dynamic resting state fMRI connectivity of neurotypical children in regions affected by cerebral palsy Open
Background: Normative childhood motor network resting-state fMRI effective connectivity is undefined, yet necessary for translatable dynamic resting-state-network-informed evaluation in pediatric cerebral palsy. Methods: Cross-spectral dyn…
View article: Research considerations for prospective studies of patients with coma and disorders of consciousness
Research considerations for prospective studies of patients with coma and disorders of consciousness Open
Disorders of consciousness are neurological conditions characterized by impaired arousal and awareness of self and environment. Behavioural responses are absent or are present but fluctuate. Disorders of consciousness are commonly encounte…
View article: The Expert Knowledge combined with AI outperforms AI Alone in Seizure Onset Zone Localization using resting state fMRI
The Expert Knowledge combined with AI outperforms AI Alone in Seizure Onset Zone Localization using resting state fMRI Open
We evaluated whether integration of expert guidance on seizure onset zone (SOZ) identification from resting state functional MRI (rs-fMRI) connectomics combined with deep learning (DL) techniques enhances the SOZ delineation in patients wi…
View article: Common Data Element for Disorders of Consciousness: Recommendations from the Working Group on Therapeutic Interventions
Common Data Element for Disorders of Consciousness: Recommendations from the Working Group on Therapeutic Interventions Open
The newly created CRF enhances systematization of future work by proposing a portfolio of measures that should be collected in the development and implementation of studies assessing novel interventions intended to increase the level of co…
View article: Correction: Common Data Elements for Disorders of Consciousness: Recommendations from the Working Group on Behavioral Phenotyping
Correction: Common Data Elements for Disorders of Consciousness: Recommendations from the Working Group on Behavioral Phenotyping Open
View article: Common Data Elements for Disorders of Consciousness: Recommendations from the Working Group in the Pediatric Population
Common Data Elements for Disorders of Consciousness: Recommendations from the Working Group in the Pediatric Population Open
Background The fundamental gap obstructing forward progress of evidenced based care in pediatric and neonatal disorders of consciousness (DoC) is the lack of defining consensus-based terminology to perform comparative research. This lack o…