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View article: Brain alterations in regions associated with end‐organ diabetic microvascular disease in diabetes mellitus: A UK Biobank study
Brain alterations in regions associated with end‐organ diabetic microvascular disease in diabetes mellitus: A UK Biobank study Open
Background Diabetes mellitus (DM) is associated with structural grey matter alterations in the brain, including changes in the somatosensory and pain processing regions seen in association with diabetic peripheral neuropathy. In this case‐…
View article: Effect of intravitreal anti-vascular endothelial growth factor treatment for neovascular age-related macular degeneration on renal function
Effect of intravitreal anti-vascular endothelial growth factor treatment for neovascular age-related macular degeneration on renal function Open
This study did not find any clinically significant change in serum markers of renal function in the one month after intravitreal ranibizumab or aflibercept. It did, however, find a non-significant rise in creatinine with aflibercept, that …
View article: Artificial Intelligence and Corneal Confocal Microscopy: The Start of a Beautiful Relationship
Artificial Intelligence and Corneal Confocal Microscopy: The Start of a Beautiful Relationship Open
Corneal confocal microscopy (CCM) is a rapid non-invasive in vivo ophthalmic imaging technique that images the cornea. Historically, it was utilised in the diagnosis and clinical management of corneal epithelial and stromal disorders. Howe…
View article: Multimodal testing reveals subclinical neurovascular dysfunction in prediabetes, challenging the diagnostic threshold of diabetes
Multimodal testing reveals subclinical neurovascular dysfunction in prediabetes, challenging the diagnostic threshold of diabetes Open
Aim To explore if novel non‐invasive diagnostic technologies identify early small nerve fibre and retinal neurovascular pathology in prediabetes. Methods Participants with normoglycaemia, prediabetes or type 2 diabetes underwent an explora…
View article: Prevalence of peripheral neuropathy in pre-diabetes: a systematic review
Prevalence of peripheral neuropathy in pre-diabetes: a systematic review Open
There is growing evidence of excess peripheral neuropathy in pre-diabetes. We aimed to determine its prevalence, including the impact of diagnostic methodology on prevalence rates, through a systematic review conducted according to Preferr…
View article: Litigation in Ophthalmology against the National Health Service in England
Litigation in Ophthalmology against the National Health Service in England Open
The annual clinical negligence bill against the National Health Service (NHS) in England has increased substantially from £0.3 billion ($0.4 billion) in 2004 and 2005 to £2.3 billion ($3.0 billion) in 2019 and 2020.1NHS ResolutionAnnual re…
View article: Do Black and Asian individuals wait longer for treatment? A survival analysis investigating the effect of ethnicity on time-to-clinic and time-to-treatment for diabetic eye disease
Do Black and Asian individuals wait longer for treatment? A survival analysis investigating the effect of ethnicity on time-to-clinic and time-to-treatment for diabetic eye disease Open
Aims/hypothesis This study explored the impact of ethnicity on time-to-clinic, time-to-treatment and rates of vision loss in people referred to hospital with diabetic eye disease. Methods A survival analysis was performed on all referrals …
View article: Prevalence of retinopathy in prediabetes: protocol for a systematic review and meta-analysis
Prevalence of retinopathy in prediabetes: protocol for a systematic review and meta-analysis Open
Introduction There is growing evidence of a higher than expected prevalence of retinopathy in prediabetes. This paper presents the protocol of a systematic review and meta-analysis of retinopathy in prediabetes. The aim of the review is to…
View article: Outcomes in randomised controlled trials of multifocal lenses in cataract surgery: the case for development of a core outcome set
Outcomes in randomised controlled trials of multifocal lenses in cataract surgery: the case for development of a core outcome set Open
Background/aims To describe and summarise the outcomes reported in randomised controlled trials of multifocal versus monofocal intraocular lenses in cataract surgery. Methods We identified all randomised controlled trials of multifocal ver…
View article: Ocriplasmin for symptomatic vitreomacular adhesion
Ocriplasmin for symptomatic vitreomacular adhesion Open
Evidence from a limited number of RCTs suggests that ocriplasmin is useful in the treatment of sVMA. However, up to 20% of eyes treated with ocriplasmin will still require additional treatment with PPV within six months. There were more oc…
View article: Multifocal versus monofocal intraocular lenses after cataract extraction
Multifocal versus monofocal intraocular lenses after cataract extraction Open
Multifocal IOLs are effective at improving near vision relative to monofocal IOLs although there is uncertainty as to the size of the effect. Whether that improvement outweighs the adverse effects of multifocal IOLs, such as glare and halo…
View article: Pigmented spherical body floating within the globe
Pigmented spherical body floating within the globe Open
Vitreous cysts are rare ocular malformations. We report an unusual case of a pigmented free-floating vitreous cyst incidentally detected in a highly myopic 28-year-old woman who was referred by her optometrist.