Explanipedia

Pathologist-like explainable AI for interpretable Gleason grading in prostate cancer Open

Gesa Mittmann, Sara Laiouar-Pedari, Hendrik A. Mehrtens, Sarah Haggenmüller, Tabea-Clara Bucher , et al. · 2025

MON-507 A rare case of high grade carcinoma presenting as unilateral adrenal metastasis with PTH related Peptide hypercalcemia and possible ectopic ACTH secretion Open

Sandhya R. Bogi, Javaria Khan, Varsha Manucha, Virginia Wright, Vishnu Garla · 2025

Disclosure: S.R. Bogi: None. J. Khan: None. V. Manucha: None. V. Wright: None. V. Garla: None. Adrenal metastases can be commonly seen in primary solid tumors like lung (42%), breast (58%), melanoma (50%) and gastrointestinal (GI) (10-16%)…

Utility of ThinPreps in Enhancing Diagnostic Precision of Fine Needle Aspiration (FNA) Samples from Lymph Nodes Open

A. Aravind, Navneet Kaur, Bilal Khan, W. Cavett, Varsha Manucha · 2025

Pathologist-like explainable AI for interpretable Gleason grading in prostate cancer Open

Gesa Mittmann, Sara Laiouar-Pedari, Hendrik A. Mehrtens, Sarah Haggenmüller, Tabea-Clara Bucher , et al. · 2024

The aggressiveness of prostate cancer, the most common cancer in men worldwide, is primarily assessed based on histopathological data using the Gleason scoring system. While artificial intelligence (AI) has shown promise in accurately pred…

The 1000 Mitoses Project: A Consensus-Based International Collaborative Study on Mitotic Figures Classification Open

Sherman Lin, Christopher Tran, Ela Bandari, Tommaso Romagnoli, Yueyang Li , et al. · 2024

Introduction. The identification of mitotic figures is essential for the diagnosis, grading, and classification of various different tumors. Despite its importance, there is a paucity of literature reporting the consistency in interpreting…

Paragangliomas Arising From the Laryngeal Paraganglia: Thyroid and Laryngeal Paragangliomas With Radiology-Pathology Correlation Open

Alia Tayara, William Townsend, Areejah Umar, Kirby G. Parker, Varsha Manucha , et al. · 2024

Paragangliomas are neuroendocrine tumors that arise from the embryonic neural crest cells of the extra-adrenal chromaffin and non-chromaffin cellular system. Paragangliomas arising from the laryngeal paraganglia, which occur in the thyroid…

Myringosclerosis Mimicking Tympanic Membrane Cholesteatoma Open

Samuel J. Hopper, Trace T. Palmer, Javaria Khan, Varsha Manucha, Jeffrey D. Carron · 2024

A Low-grade Sinonasal Sarcoma Harboring EWSR1::BEND2: Expanding the Differential Diagnosis of Sinonasal Spindle Cell Neoplasms Open

Doreen N. Palsgrove, Varsha Manucha, Jason Y. Park, Justin A. Bishop · 2023

A Rare Case of Metastatic Extragonadal Yolk Sac Tumor – A Challenging Diagnosis on Cytomorphology Open

N Rahmanov, Navneet Kaur, Varsha Manucha · 2022

Introduction/Objective Yolk sac tumors are characterized by variable histologic patterns and broad cytologic spectrum; thereby making the distinction from a poorly differentiated adenocarcinoma in a metastatic site extremely challenging. W…

Frankly Invasive Carcinoma Ex-intraductal Carcinoma: Expanding on an Emerging and Perplexing Concept in Salivary Gland Tumor Pathology Open

Anne C. McLean-Holden, Lisa M. Rooper, Daniel Lubin, Kelly R. Magliocca, Varsha Manucha , et al. · 2022

Analysis of the risk of malignancy associated with the basaloid and oncocytic subtypes of the salivary gland neoplasm of unknown malignant potential (SUMP) category in the Milan system Open

Varsha Manucha, María F. González, Israh Akhtar · 2021

BACKGROUND The salivary gland neoplasm of unknown malignant potential (SUMP) category reflects the cytomorphologic overlap and complexity of reporting salivary gland cytology in the Milan system. It includes neoplasms for which a diagnosis…

Abstracts from USCAP 2021: Cytopathology (158-237) Open

Jason Chair, Rhonda K. Yantiss, Kristin Jensen Chair, Cme Subcommittee, Laura C. Collins , et al. · 2021

Abstracts from USCAP 2021: Cytopathology (158-237) Open

Jason Chair, Rhonda K. Yantiss, Kristin Jensen Chair, Cme Subcommittee, Laura C. Collins , et al. · 2021

Threshold for interpretation of p16 immunostaining in fine-needle aspirate specimens of metastatic oropharyngeal squamous cell carcinoma Open

Varsha Manucha, Tejal Patel, Dianne Grunes, Israh Akhtar · 2020

We recommend that even minimal nuclear expression for p16 in viable tumor fragments must be considered as positive in cytology specimens. Expression limited to only background single tumor cells or in a necrotic specimen must be interprete…

Clinicopathologic correlation is essential for diagnosis of metastatic aggressive variant prostate carcinoma: A series of two cases Open

Varsha Manucha, JohnClark Henegan · 2020

A subset of patients with castrate resistant prostate cancer, may evolve into androgen receptor-independent phenotype, clinically characterized by low serum levels of prostate-specific antigen and rapidly progressive disease course, referr…

Clinicopathologic Diagnostic Approach to Aggressive Variant Prostate Cancer Open

Varsha Manucha, John C. Henegan · 2019

Issue Information Open

Carlos Bedrossian, Zubair Baloch, Pennsylvania Philadelphia, Fernando Schmitt, Carmen M. Perrino , et al. · 2018

Endoscopic ultrasound-guided fine needle aspiration

Incidental Finding of Renal Oncocytoma in a Patient With Agent Orange Exposure Open

Amit Reddy, Mary Sessums, Varsha Manucha, John C. Henegan · 2018

More than 3 million veterans during the Vietnam War had exposure to Agent Orange (AO), an herbicide containing dioxin linked to increased cancer risk. There is an association between AO and hematological disorders, but only a few cases hav…

Rosai-Dorfman Disease with progressive central nervous system involvement requiring multiple surgical intervention: A case report Open

Andrew M. Smith, Tamir Tawfik, Jared J. Marks, Jason E. Tullis, Louis H. Harkey , et al. · 2018

• Rosai-Dorfman Disease can present with involvement of the cranium and spine simultaneously. • Spinal involvement may lead to instability and neural compression requiring intervention. • Though typically benign, progression of the CNS inv…

Issue Information Open

Carlos Bedrossian, Zubair Baloch, Pennsylvania Philadelphia, Fernando Schmitt, Guodong Zhao , et al. · 2018

Ease of `interpretation' of cytological smears stained with modified ultrafast papanicolaou stain: Interobserver agreement and reproducibility.Cover legend: (A and B): High (40× magnification-A) and medium (20-magnification-B) images of a …

41 Malignant Pheochromocytoma With a Rare Metastasis to Thoracic Spine Open

Amit Reddy, W. Shannon Orr, Jaswinder Kaur, Varsha Manucha · 2018

Pheochromocytoma is a rare, destructive neuroendocrine malignancy that occurs primarily in the adrenal glands and can metastasize anywhere along the sympathetic chain. The diagnosis of malignant pheochromocytoma is often problematic to ana…

Changing Trends and Practices in Cytopathology Open

María F. González, Israh Akhtar, Varsha Manucha · 2017

Objective: To explore the current and anticipated changes in the practice of cytopathology. Study Design: The present review is based on a review of recent literature and an evaluation of the authors' personal experiences. Results and Conc…

Invasive Adenocarcinoma Arising in Intraductal Papillary Mucinous Neoplasm of Gastric Heterotopic Pancreas Open

Tejal Patel, Michael Doherty, W. Shannon Orr, Varsha Manucha · 2016

Histiocytic Sarcoma in a Kidney Transplant Patient: A Case Report and Review of the Literature Open

Maressa Pollen, Siraj M. El Jamal, Jack R. Lewin, Varsha Manucha · 2016

Objective . Histiocytic sarcoma (HS) is an aggressive neoplasm with only limited number of reported series of cases and rare case reports of occurrence as a posttransplant neoplastic disorder. The etiology and pathogenesis of the disease i…

Villous Adenoma of the Urinary Bladder: A Brief Review of the Literature Open

Jindong Wang, Varsha Manucha · 2015

Villous adenoma is a rare neoplasm in the urinary tract. It usually occurs in patients older than 50 years with a male predominance. The affected patients typically present with hematuria, irritative voiding symptoms, and mucosuria. The ma…

Histopathologic Trends in Bladder Diverticula Open

Jindong Wang, Viren Patel, Susan Inniss, Varsha Manucha · 2015

Bladder diverticula (BD) are saccular evaginations of urinary bladder mucosa that are encountered in all age groups due to congenital or acquired weakness in the muscular bladder wall.Most are small and asymptomatic; however a subset can g…

Oncologic outcomes in men with metastasis to the prostatic anterior fat pad lymph nodes: a multi-institution international study Open

Young Suk Kwon, Yun‐Sok Ha, Parth K. Modi, Amirali Salmasi, Jaspreet Parihar , et al. · 2015

There was no significant difference in the rate of BCR between the PAFP LN+ and PLN+ groups. The PAFP likely represents a landing zone that is different from the PLNs for PCa metastasis. Therefore, the removal and pathologic analysis of PA…

Cystic adenomatoid tumor of the uterus Open

Varsha Manucha, Azniv Azar, James Shwayder, Joseph L Hudgens, Jack R. Lewin · 2015

We present a case of a cystic adenomatoid tumor in a 40-year-old woman. The tumor was an intramural multicystic mass, histologically similar to a multicystic mesothelioma. Cystic adenomatoid tumors of the uterus are extremely rare. They pr…

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