Varsha Thoppey Manoharan
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View article: EXTH-103. A prototype mRNA LNP neoantigen vaccine remodels the tumour microenvironment of a syngeneic model of glioblastoma
EXTH-103. A prototype mRNA LNP neoantigen vaccine remodels the tumour microenvironment of a syngeneic model of glioblastoma Open
Despite significant advances in understanding the biology of glioblastoma (GBM), the disease remains fatal within 15 months of diagnosis. Emerging immunotherapies including vaccines targeting somatic alterations hold promise but need to ad…
View article: EXTH-64. Allogeneic CAR-DNT cell therapy to overcome spatial heterogeneity in glioblastoma
EXTH-64. Allogeneic CAR-DNT cell therapy to overcome spatial heterogeneity in glioblastoma Open
Glioblastoma (GBM) is the most common primary malignant brain tumour, with a 5-year survival rate under 10%. Chimeric antigen receptor (CAR)-T cell therapy shows promise, but tumour heterogeneity – especially between the tumour core and in…
View article: Development and first-in-human CAR T therapy against the pathognomonic MiT-fusion driven protein GPNMB
Development and first-in-human CAR T therapy against the pathognomonic MiT-fusion driven protein GPNMB Open
CAR T therapy for solid tumors is limited by a lack of safe and uniformly expressed cell-surface targets. Here, we identify the MiT fusion-driven protein GPNMB as being highly, homogeneously, and stably expressed in primary and relapsed tr…
View article: Supplementary Figures from CD33–CD123 IF-THEN Gating Reduces Toxicity while Enhancing the Specificity and Memory Phenotype of AML-Targeting CAR-T Cells
Supplementary Figures from CD33–CD123 IF-THEN Gating Reduces Toxicity while Enhancing the Specificity and Memory Phenotype of AML-Targeting CAR-T Cells Open
additional and extended data from stuying constituitive and gated CAR-T cells.
View article: Supplementary Data 1 from CD33–CD123 IF-THEN Gating Reduces Toxicity while Enhancing the Specificity and Memory Phenotype of AML-Targeting CAR-T Cells
Supplementary Data 1 from CD33–CD123 IF-THEN Gating Reduces Toxicity while Enhancing the Specificity and Memory Phenotype of AML-Targeting CAR-T Cells Open
Single cell data of the clusters, gene expresion, biomarker and called annotations
View article: Data from CD33–CD123 IF-THEN Gating Reduces Toxicity while Enhancing the Specificity and Memory Phenotype of AML-Targeting CAR-T Cells
Data from CD33–CD123 IF-THEN Gating Reduces Toxicity while Enhancing the Specificity and Memory Phenotype of AML-Targeting CAR-T Cells Open
Chimeric antigen receptor (CAR) T-cell therapy has remarkably succeeded in treating lymphoblastic leukemia. However, its success in acute myeloid leukemia (AML) remains elusive because of the risk of on-target off-tumor toxicity to hematop…
View article: Spatiotemporal modeling reveals high-resolution invasion states in glioblastoma
Spatiotemporal modeling reveals high-resolution invasion states in glioblastoma Open
The compendium of programs presented here provides a basis for rational targeting of tumor and/or TME components. We anticipate that our approach will facilitate an ecosystem-level understanding of the immediate and long-term consequences …
View article: Spatiotemporal modeling reveals high-resolution invasion states in glioblastoma
Spatiotemporal modeling reveals high-resolution invasion states in glioblastoma Open
Diffuse invasion of glioblastoma cells through normal brain tissue is a key contributor to tumor aggressiveness, resistance to conventional therapies, and dismal prognosis in patients. A deeper understanding of how components of the tumor …
View article: EPCO-51. FUNCTIONAL ANALYSIS OF REGULATORY MUTATIONS IN PEDIATRIC BRAIN TUMORS
EPCO-51. FUNCTIONAL ANALYSIS OF REGULATORY MUTATIONS IN PEDIATRIC BRAIN TUMORS Open
Pediatric brain tumors are the primary cause of cancer related mortality in children and are characterized by low mutations burden. The known somatic drivers reside in the coding regions of the genome. The role of non-coding mutations in b…
View article: EPCO-05. SPATIOTEMPORAL MODELLING OF GLIOBLASTOMA FOR DRUG PREDICTION
EPCO-05. SPATIOTEMPORAL MODELLING OF GLIOBLASTOMA FOR DRUG PREDICTION Open
Glioblastoma (GBM) is a lethal primary brain malignancy characterized by inevitable relapse. Understanding intra-tumoral heterogeneity and the microenvironmental influence on tumor progression is key to developing effective therapies. We e…