Varuna Jasodanand
YOU?
Author Swipe
View article: Prognostic performance across Alzheimer’s biomarkers, multi-modal physiological measures, and clinical history in asymptomatic individuals
Prognostic performance across Alzheimer’s biomarkers, multi-modal physiological measures, and clinical history in asymptomatic individuals Open
Importance Evaluating prognostic performance of Alzheimer’s biomarkers, multi-modal physiological measures, and clinical history in asymptomatic individuals versus established risk factors in asymptomatic individuals is can inform effcient…
View article: An AI‐first framework for multimodal data in Alzheimer's disease and related dementias
An AI‐first framework for multimodal data in Alzheimer's disease and related dementias Open
Advancing the understanding and management of Alzheimer's disease and related dementias requires integrating and analyzing diverse data modalities. Traditional diagnostic tools, like neuroimaging, provide valuable insights but are limited …
View article: Agentic memory-augmented retrieval and evidence grounding for medical question-answering tasks
Agentic memory-augmented retrieval and evidence grounding for medical question-answering tasks Open
Objective: To evaluate if a tool-using agent-based system utilizing large language models (LLMs) for medical question-answering (QA) tasks outperforms standalone LLMs. Methods: We developed a unified, open-source LLM-based agentic system t…
View article: PodGPT: an audio-augmented large language model for research and education
PodGPT: an audio-augmented large language model for research and education Open
The proliferation of scientific podcasts has generated an extensive repository of educational content, rich in specialized terminology, diverse topics, and expert dialogues. Here, we introduce a computational framework designed to enhance …
View article: AI-driven fusion of neurological work-up for assessment of biological Alzheimer’s disease
AI-driven fusion of neurological work-up for assessment of biological Alzheimer’s disease Open
Alzheimer’s disease (AD) diagnosis hinges on detecting amyloid beta (A β ) plaques and neurofibrillary tau ( τ ) tangles. While amyloid PET imaging is now clinically approved, tau PET remains largely restricted to research settings. These …
View article: PodGPT: An audio-augmented large language model for research and education
PodGPT: An audio-augmented large language model for research and education Open
The proliferation of scientific podcasts has generated an extensive repository of audio content, rich in specialized terminology, diverse topics, and expert dialogues. Here, we introduce a computational framework designed to enhance large …
View article: AI-based differential diagnosis of dementia etiologies on multimodal data
AI-based differential diagnosis of dementia etiologies on multimodal data Open
Differential diagnosis of dementia remains a challenge in neurology due to symptom overlap across etiologies, yet it is crucial for formulating early, personalized management strategies. Here, we present an artificial intelligence (AI) mod…
View article: Sex differences in body temperature and neural power spectra in response to repeated restraint stress
Sex differences in body temperature and neural power spectra in response to repeated restraint stress Open
Repeated stress is associated with an increased risk of developing psychiatric illnesses such as post-traumatic stress disorder (PTSD), which is more common in women, yet the neurobiology behind this sex difference is unknown. Habituation …
View article: AI-based differential diagnosis of dementia etiologies on multimodal data
AI-based differential diagnosis of dementia etiologies on multimodal data Open
Differential diagnosis of dementia remains a challenge in neurology due to symptom overlap across etiologies, yet it is crucial for formulating early, personalized management strategies. Here, we present an AI model that harnesses a broad …
View article: The association between 73 Alzheimer’s disease risk variants and white matter microstructural decline in aging
The association between 73 Alzheimer’s disease risk variants and white matter microstructural decline in aging Open
Background Although several prior diffusion MRI studies have indicated a role of medial temporal lobe (MTL) white matter microstructural decline in Alzheimer’s disease (AD), it is unclear which AD risk genes are associated with this declin…
View article: The association between 73 Alzheimer’s disease risk variants and white matter microstructural decline in aging
The association between 73 Alzheimer’s disease risk variants and white matter microstructural decline in aging Open
Background Although several prior diffusion MRI studies have indicated a role of medial temporal lobe (MTL) white matter microstructural decline in Alzheimer’s disease (AD), it is unclear which AD risk genes are associated with this declin…
View article: Leveraging longitudinal diffusion MRI data to quantify differences in white matter microstructural decline in normal and abnormal aging
Leveraging longitudinal diffusion MRI data to quantify differences in white matter microstructural decline in normal and abnormal aging Open
Introduction It is unclear how rates of white matter microstructural decline differ between normal aging and abnormal aging. Methods Diffusion MRI data from several well‐established longitudinal cohorts of aging (Alzheimer's Disease Neuroi…
View article: Leveraging longitudinal diffusion MRI data to quantify differences in white matter microstructural decline in normal and abnormal aging
Leveraging longitudinal diffusion MRI data to quantify differences in white matter microstructural decline in normal and abnormal aging Open
INTRODUCTION It is unclear how rates of white matter microstructural decline differ between normal aging and abnormal aging. METHODS Diffusion MRI data from several well-established longitudinal cohorts of aging [Alzheimer’s Neuroimaging I…
View article: White matter microstructural metrics are sensitively associated with clinical staging in Alzheimer's disease
White matter microstructural metrics are sensitively associated with clinical staging in Alzheimer's disease Open
Introduction White matter microstructure may be abnormal along the Alzheimer's disease (AD) continuum. Methods Diffusion magnetic resonance imaging (dMRI) data from the Alzheimer's Disease Neuroimaging Initiative (ADNI, n = 627), Baltimore…
View article: Leveraging longitudinal, multi‐site diffusion MRI data in conjunction with free‐water analysis to characterize patterns of white matter neurodegeneration in aging
Leveraging longitudinal, multi‐site diffusion MRI data in conjunction with free‐water analysis to characterize patterns of white matter neurodegeneration in aging Open
Background Several prior studies have used diffusion MRI to investigate the relationship between white matter microstructure and aging; however, many of these studies used conventional diffusion MRI measures and single site data. The goal …