Vasanth Ramamurthy
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View article: Cilium proteomics reveals Numb as a positive regulator of the Hedgehog signaling pathway
Cilium proteomics reveals Numb as a positive regulator of the Hedgehog signaling pathway Open
SUMMARY The transduction of Hedgehog (Hh) signaling relies on the primary cilium, a cell surface organelle serving as a signaling hub for the cell. Using proximity labeling and quantitative proteomics, we identified Numb as a new ciliary p…
View article: Mutations in PNPLA6 are linked to photoreceptor degeneration and various forms of childhood blindness
Mutations in PNPLA6 are linked to photoreceptor degeneration and various forms of childhood blindness Open
Blindness due to retinal degeneration affects millions of people worldwide, but many disease-causing mutations remain unknown. PNPLA6 encodes the patatin-like phospholipase domain containing protein 6, also known as neuropathy target ester…