Vasantha Devasiri
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View article: Prevalence and predictors of antibiotic prescription among patients hospitalized with viral lower respiratory tract infections in Southern Province, Sri Lanka
Prevalence and predictors of antibiotic prescription among patients hospitalized with viral lower respiratory tract infections in Southern Province, Sri Lanka Open
Background Antimicrobial overprescription is common for lower respiratory tract infections (LRTI), as viral and bacterial infections generally present with similar clinical features. Overprescription is associated with downstream antimicro…
View article: Comprehensive diagnostic testing identifies diverse aetiologies of acute febrile illness among hospitalised children and adults in Sri Lanka: a prospective cohort study
Comprehensive diagnostic testing identifies diverse aetiologies of acute febrile illness among hospitalised children and adults in Sri Lanka: a prospective cohort study Open
Introduction Acute febrile illness (AFI) is a common cause of hospital admissions in tropical settings. Identifying AFI aetiology is essential for guiding clinicians’ diagnoses and developing diagnostic and management guidelines. We used r…
View article: Host-response Transcriptional Biomarkers Accurately Discriminate Bacterial and Viral Infections of Global Relevance
Host-response Transcriptional Biomarkers Accurately Discriminate Bacterial and Viral Infections of Global Relevance Open
Limited diagnostics challenge management of acute febrile illness and sepsis (AFI/sepsis) globally. We generated transcriptomes for a 294-participant (USA, Sri Lanka) discovery cohort with AFI/sepsis. We used lasso to derive gene expressio…
View article: Correction: Outcomes among children and adults at risk of severe dengue in Sri Lanka: Opportunity for outpatient case management in countries with high disease burden
Correction: Outcomes among children and adults at risk of severe dengue in Sri Lanka: Opportunity for outpatient case management in countries with high disease burden Open
[This corrects the article DOI: 10.1371/journal.pntd.0010091.].
Outcomes among children and adults at risk of severe dengue in Sri Lanka: Opportunity for outpatient case management in countries with high disease burden Open
Background Healthcare systems in dengue-endemic countries are often overburdened due to the high number of patients hospitalized according to dengue management guidelines. We systematically evaluated clinical outcomes in a large cohort of …
The Host Response to Viral Infections Reveals Common and Virus-Specific Signatures in the Peripheral Blood Open
Viruses cause a wide spectrum of clinical disease, the majority being acute respiratory infections (ARI). In most cases, ARI symptoms are similar for different viruses although severity can be variable. The objective of this study was to u…
Creating a COVID-19 bio-secure environment: experience from a medical faculty in Sri Lanka Open
The COVID-19 pandemic has presented educational institutions and educationists with unprecedented challenges with regard to the delivery of high-quality education. The challenges have been greater for the medical education institutions as …
Unsuspected Dengue Causes Acute Febrile Illness in Rural and Semi-Urban Southern Sri Lanka Open
Acute dengue may be under-recognized in other regions because of limited studies and tools for rapid diagnosis.Dengue virus (DENV), a globally emerging cause of undifferentiated fever, has been documented in the heavily urbanized western c…
Outbreak of severe acute respiratory infection in Southern Province, Sri Lanka in 2018: a cross-sectional study Open
Objectives To determine aetiology of illness among children and adults presenting during outbreak of severe respiratory illness in Southern Province, Sri Lanka, in 2018. Design Prospective, cross-sectional study. Setting 1600-bed, public, …
A case of star fruit induced acute oxalate nephropathy in a previously healthy child Open
Sri Lanka Journal of Child Health, 2020; 49(2): 178-179
Previously Derived Host Gene Expression Classifiers Identify Bacterial and Viral Etiologies of Acute Febrile Respiratory Illness in a South Asian Population Open
Background Pathogen-based diagnostics for acute respiratory infection (ARI) have limited ability to detect etiology of illness. We previously showed that peripheral blood-based host gene expression classifiers accurately identify bacterial…
Geospatial analysis of dengue emergence in rural areas in the Southern Province of Sri Lanka Open
Background Dengue is a major cause of acute febrile illness in Sri Lanka. Dengue has historically been considered an urban disease. In 2012–2013, we documented that acute dengue was surprisingly associated with self-reported rural residenc…
Respiratory Viral Infection: An Underappreciated Cause of Acute Febrile Illness Admissions in Southern Sri Lanka Open
The contribution of respiratory viruses to acute febrile illness (AFI) burden is poorly characterized. We describe the prevalence, seasonality, and clinical features of respiratory viral infection among AFI admissions in Sri Lanka. We enro…
Documentation errors in paediatric drug charts: an Audit Open
INTRODUCTION:Documentation errors leading to medication errors pose a health risk to hospitalised patents. Maintenance of the drug chart in hospitalized patients is done by nursing staff in Sri Lanka. This audit was carried out in a paedia…
2018. Host Gene Expression Classifiers Distinguish Bacterial and Viral Infections in Sri Lankan Patients with Acute Febrile Respiratory Illness Open
BACKGROUND: Acute febrile illness is a frequent cause of hospitalization in the tropics and often presents with respiratory symptoms, even when caused by nonrespiratory pathogens. Previously, host-based gene expression signatures accuratel…
Evaluation of the WHO 2009 classification for diagnosis of acute dengue in a large cohort of adults and children in Sri Lanka during a dengue-1 epidemic Open
In a large cohort with AFI, we identified features predictive of dengue vs other AFI and secondary vs primary dengue in adults versus children. The 2009 WHO dengue classification criteria had high sensitivity but low specificity compared t…
Burden and Seasonality of Viral Acute Respiratory Tract Infections among Outpatients in Southern Sri Lanka Open
In tropical and subtropical settings, the epidemiology of viral acute respiratory tract infections varies widely between countries. We determined the etiology, seasonality, and clinical presentation of viral acute respiratory tract infecti…
Emergence of Epidemic Dengue-1 Virus in the Southern Province of Sri Lanka Open
We describe the first epidemic of DENV-1 in the Southern Province of Sri Lanka in a population known to be susceptible to this serotype because of prior study. Dengue accounted for 40% of acute febrile illnesses in the current study. The e…