Vasco Queiroga
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View article: Optimization of velocity receptor transduction in CAR T cells
Optimization of velocity receptor transduction in CAR T cells Open
Limited infiltration capacity significantly limits the effectiveness of chimeric antigen receptor (CAR) T cells for solid tumors. We have recently developed a large family of highly modular synthetic cytokine receptors termed velocity rece…
View article: 3D multi-omic mapping of whole nondiseased human fallopian tubes at cellular resolution reveals a large incidence of ovarian cancer precursors
3D multi-omic mapping of whole nondiseased human fallopian tubes at cellular resolution reveals a large incidence of ovarian cancer precursors Open
Uncovering the spatial and molecular landscape of precancerous lesions is essential for developing meaningful cancer prevention and early detection strategies. High-Grade Serous Carcinoma (HGSC), the most lethal gynecologic malignancy, oft…
View article: Three-dimensional assessments are necessary to determine the true, spatially resolved composition of tissues
Three-dimensional assessments are necessary to determine the true, spatially resolved composition of tissues Open
Methods for spatially resolved cellular profiling of tissue sections enable in-depth study of inter- and intra-sample heterogeneity but often profile small regions, requiring evaluation of many samples to compensate for limited assessment.…
View article: InterpolAI: deep learning-based optical flow interpolation and restoration of biomedical images for improved 3D tissue mapping
InterpolAI: deep learning-based optical flow interpolation and restoration of biomedical images for improved 3D tissue mapping Open
View article: Integration of nuclear morphology and 3D imaging to profile cellular neighborhoods
Integration of nuclear morphology and 3D imaging to profile cellular neighborhoods Open
Nuclear morphology is an indicator of cellular function and disease states, as changes in nuclear size, shape, and texture often reflect underlying disease-related genetic, epigenetic, and microenvironmental alterations. For disease diagno…
View article: Combined assembloid modeling and 3D whole-organ mapping captures the microanatomy and function of the human fallopian tube
Combined assembloid modeling and 3D whole-organ mapping captures the microanatomy and function of the human fallopian tube Open
The fallopian tubes play key roles in processes from pregnancy to ovarian cancer where three-dimensional (3D) cellular and extracellular interactions are important to their pathophysiology. Here, we develop a 3D multicompartment assembloid…
View article: Generative interpolation and restoration of images using deep learning for improved 3D tissue mapping
Generative interpolation and restoration of images using deep learning for improved 3D tissue mapping Open
The development of novel imaging platforms has improved our ability to collect and analyze large three-dimensional (3D) biological imaging datasets. Advances in computing have led to an ability to extract complex spatial information from t…
View article: Genomic editing in <i>Burkholderia multivorans</i> by CRISPR/Cas9
Genomic editing in <i>Burkholderia multivorans</i> by CRISPR/Cas9 Open
Burkholderia cepacia complex bacteria have emerged as opportunistic pathogens in patients with cystic fibrosis and immunocompromised individuals, causing life-threatening infections. Because of the relevance of these microorganisms, geneti…
View article: Precision-engineered biomimetics: the human fallopian tube
Precision-engineered biomimetics: the human fallopian tube Open
The fallopian tube has an essential role in several physiological and pathological processes from pregnancy to ovarian cancer. However, there are no biologically relevant models to study its pathophysiology. The state-of-the-art organoid m…