Vasiliki Lygirou
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View article: Proteomic Analysis of Bone Marrow CD138+ Cells to Identify Proteins Associated With the Response of Multiple Myeloma Patients to Commonly Used Therapeutic Regimens
Proteomic Analysis of Bone Marrow CD138+ Cells to Identify Proteins Associated With the Response of Multiple Myeloma Patients to Commonly Used Therapeutic Regimens Open
Multiple myeloma (MM) remains incurable; gaps in our understanding of MM molecular pathogenesis and drugs’ resistance mechanisms are involved in the failure of therapies. This study aims to identify proteins significantly impacting MM pati…
View article: Tear Proteomics in Children and Adolescents with Type 1 Diabetes: A Promising Approach to Biomarker Identification of Diabetes Pathogenesis and Complications
Tear Proteomics in Children and Adolescents with Type 1 Diabetes: A Promising Approach to Biomarker Identification of Diabetes Pathogenesis and Complications Open
The aim of the current study was to investigate the tear proteome in children and adolescents with type 1 diabetes (T1D) compared to healthy controls, and to identify differences in the tear proteome of children with T1D depending on diffe…
View article: Investigation of the human-gut-kidney axis by fecal proteomics, highlights molecular mechanisms affected in CKD
Investigation of the human-gut-kidney axis by fecal proteomics, highlights molecular mechanisms affected in CKD Open
Collectively, this exploratory fecal proteomic analysis highlighted changes in human and bacterial proteins reflecting inflammation and reduced saccharolytic fermentation in CKD4/CKD1, plausibly affecting the butyrate synthesis pathways in…
View article: Ferroptosis-protective membrane domains in quiescence
Ferroptosis-protective membrane domains in quiescence Open
View article: Data-Independent Acquisition Mass Spectrometry Analysis of FFPE Rectal Cancer Samples Offers In-Depth Proteomics Characterization of the Response to Neoadjuvant Chemoradiotherapy
Data-Independent Acquisition Mass Spectrometry Analysis of FFPE Rectal Cancer Samples Offers In-Depth Proteomics Characterization of the Response to Neoadjuvant Chemoradiotherapy Open
Locally advanced rectal cancer (LARC) presents a challenge in identifying molecular markers linked to the response to neoadjuvant chemoradiotherapy (nCRT). This study aimed to utilize a sensitive proteomic method, data-independent mass spe…
View article: Data independent acquisition mass spectrometry (DIA-MS) analysis of FFPE rectal cancer samples offers in depth proteomics characterization of response to neoadjuvant chemoradiotherapy
Data independent acquisition mass spectrometry (DIA-MS) analysis of FFPE rectal cancer samples offers in depth proteomics characterization of response to neoadjuvant chemoradiotherapy Open
Background Understanding the molecular features associated with response to neoadjuvant chemoradiotherapy is an unmet clinical need in locally advanced rectal cancer (LARC). The aim of the study was to apply a high-sensitivity proteomic ap…
View article: Ferroptosis-Protective Membrane Domains in Quiescence
Ferroptosis-Protective Membrane Domains in Quiescence Open
Summary Quiescence is a common cellular state, required for stem-cell maintenance and microorganismal survival under stress conditions or starvation. However, the mechanisms promoting quiescence maintenance remain poorly known. Plasma memb…
View article: Ferroptosis-Protective Membrane Domains in Quiescence
Ferroptosis-Protective Membrane Domains in Quiescence Open
View article: Proteomic Analysis of Prostate Cancer FFPE Samples Reveals Markers of Disease Progression and Aggressiveness
Proteomic Analysis of Prostate Cancer FFPE Samples Reveals Markers of Disease Progression and Aggressiveness Open
Prostate cancer (PCa) is the second most common cancer in men. Diagnosis and risk assessment are widely based on serum Prostate Specific Antigen (PSA) and biopsy, which might not represent the exact degree of PCa risk. Towards the discover…
View article: Plasma Proteomics in Healthy Subjects with Differences in Tissue Glucocorticoid Sensitivity Identifies A Novel Proteomic Signature
Plasma Proteomics in Healthy Subjects with Differences in Tissue Glucocorticoid Sensitivity Identifies A Novel Proteomic Signature Open
Significant inter-individual variation in terms of susceptibility to several stress-related disorders, such as myocardial infarction and Alzheimer’s disease, and therapeutic response has been observed among healthy subjects. The molecular …
View article: Urine peptidome analysis in cardiorenal syndrome reflects molecular processes
Urine peptidome analysis in cardiorenal syndrome reflects molecular processes Open
View article: A Novel Pipeline for Drug Repurposing for Bladder Cancer Based on Patients’ Omics Signatures
A Novel Pipeline for Drug Repurposing for Bladder Cancer Based on Patients’ Omics Signatures Open
Multi-omics signatures of patients with bladder cancer (BC) can guide the identification of known de-risked therapeutic compounds through drug repurposing, an approach not extensively explored yet. In this study, we target drug repurposing…
View article: Multiplexed MRM-based protein quantification of putative prognostic biomarkers for chronic kidney disease progression in plasma
Multiplexed MRM-based protein quantification of putative prognostic biomarkers for chronic kidney disease progression in plasma Open
Current diagnostic measures for Chronic Kidney Disease (CKD) include detection of reduced estimated glomerular filtration rate (eGFR) and albuminuria, which have suboptimal accuracies in predicting disease progression. The disease complexi…
View article: Proteomics Analysis of Formalin Fixed Paraffin Embedded Tissues in the Investigation of Prostate Cancer
Proteomics Analysis of Formalin Fixed Paraffin Embedded Tissues in the Investigation of Prostate Cancer Open
Prostate cancer (PCa) is one of the leading causes of death in men worldwide. The molecular features, associated with the onset and progression of the disease, are under vigorous investigation. Formalin-fixed paraffin-embedded (FFPE) tissu…
View article: High resolution analysis of the intracellular proteome of cervical cancer cell lines unveils novel regulators of cervical carcinogenesis
High resolution analysis of the intracellular proteome of cervical cancer cell lines unveils novel regulators of cervical carcinogenesis Open
Cervical cancer remains the fourth most common and most lethal type of cancer in women, despite the applied regular screening and prevention strategies, while the available treatment schemes still pose a threat to fertility. Substantial un…
View article: Systems biology identifies cytosolic PLA2 as a target in vascular calcification treatment
Systems biology identifies cytosolic PLA2 as a target in vascular calcification treatment Open
Although cardiovascular disease (CVD) is the leading cause of morbimortality worldwide, promising new drug candidates are lacking. We compared the arterial high-resolution proteome of patients with advanced versus early-stage CVD to predic…
View article: Implications of the mitochondrial interactome of mammalian thioredoxin 2 for normal cellular function and disease
Implications of the mitochondrial interactome of mammalian thioredoxin 2 for normal cellular function and disease Open
View article: Membrane proteomics of cervical cancer cell lines reveal insights on the process of cervical carcinogenesis
Membrane proteomics of cervical cancer cell lines reveal insights on the process of cervical carcinogenesis Open
The available therapeutic approaches for cervical cancer can seriously affect the fertility potential of patient; thus, there is a pressing requirement for less toxic and targeted therapies. The membrane proteome is a potential source of t…
View article: Plasma proteomic analysis reveals altered protein abundances in cardiovascular disease
Plasma proteomic analysis reveals altered protein abundances in cardiovascular disease Open
View article: Novel structural approaches concerning HPV proteins: Insight into targeted therapies for cervical cancer (Review)
Novel structural approaches concerning HPV proteins: Insight into targeted therapies for cervical cancer (Review) Open
Cervical cancer incidence is tightly linked to HPV infection, and particularly virus types 16 and 18 cause the majority of cases presenting with pre-cancerous stages of cervical intraepithelial neoplasia (CIN). Structural and functional in…
View article: MOESM3 of Plasma proteomic analysis reveals altered protein abundances in cardiovascular disease
MOESM3 of Plasma proteomic analysis reveals altered protein abundances in cardiovascular disease Open
Additional file 3. Test set analysis results. List of peptides and proteins along with the detailed protein identification and relative quantification data per sample in the test set. The detailed list of the differentially expressed prote…
View article: Supplementary data
Supplementary data Open
Supplementary data to "High resolution analysis of the intracellular proteome of cervical cancer cell lines unveils novel regulators of cervical carcinogenesis"
View article: MOESM4 of Plasma proteomic analysis reveals altered protein abundances in cardiovascular disease
MOESM4 of Plasma proteomic analysis reveals altered protein abundances in cardiovascular disease Open
Additional file 4. Ingenuity Pathway Analysis of the verified proteins. Lists of the canonical pathways and biological functions that resulted from the Ingenuity Pathway Analysis of the 39 verified proteins.
View article: MOESM1 of Plasma proteomic analysis reveals altered protein abundances in cardiovascular disease
MOESM1 of Plasma proteomic analysis reveals altered protein abundances in cardiovascular disease Open
Additional file 1. Discovery set analysis results. List of peptides and proteins along with the detailed protein identification and relative quantification data per sample in the discovery set. The list of differentially expressed proteins…
View article: Supplementary data
Supplementary data Open
Supplementary data to "High resolution analysis of the intracellular proteome of cervical cancer cell lines unveils novel regulators of cervical carcinogenesis"
View article: MOESM2 of Plasma proteomic analysis reveals altered protein abundances in cardiovascular disease
MOESM2 of Plasma proteomic analysis reveals altered protein abundances in cardiovascular disease Open
Additional file 2. Pathway annotation results. Pathway (Cytoscape) analysis of the proteins identified in the discovery set. Pathways predicted based on proteins identified by at least two peptides are also shown.
View article: High Resolution Proteomic Analysis of the Cervical Cancer Cell Lines Secretome Documents Deregulation of Multiple Proteases
High Resolution Proteomic Analysis of the Cervical Cancer Cell Lines Secretome Documents Deregulation of Multiple Proteases Open
High resolution proteomics analysis of cervical cancer secretome revealed significantly deregulated biological processes and proteins implicated in cervical carcinogenesis.
View article: Proteomic Analysis of Normal and Cancer Cervical Cell Lines Reveals Deregulation of Cytoskeleton-associated Proteins
Proteomic Analysis of Normal and Cancer Cervical Cell Lines Reveals Deregulation of Cytoskeleton-associated Proteins Open
These novel identified proteins provide the impetus for further functional studies to dissect the mechanisms operating in the two distinct pathways of cervical carcinogenesis.
View article: Proteomics analysis of bladder cancer invasion: Targeting EIF3D for therapeutic intervention
Proteomics analysis of bladder cancer invasion: Targeting EIF3D for therapeutic intervention Open
Patients with advanced bladder cancer have poor outcomes, indicating a need for more efficient therapeutic approaches. This study characterizes proteomic changes underlying bladder cancer invasion aiming for the better understanding of dis…
View article: Cervical Cancer Cell Line Secretome Highlights the Roles of Transforming Growth Factor-Beta-Induced Protein ig-h3, Peroxiredoxin-2, and NRF2 on Cervical Carcinogenesis
Cervical Cancer Cell Line Secretome Highlights the Roles of Transforming Growth Factor-Beta-Induced Protein ig-h3, Peroxiredoxin-2, and NRF2 on Cervical Carcinogenesis Open
Cancer cells acquire unique secretome compositions that contribute to tumor development and metastasis. The aim of our study was to elucidate the biological processes involved in cervical cancer, by performing a proteomic analysis of the s…