Vineet Bhandari
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View article: Atomistic modulation of <scp>MIF</scp> ‐2 structure, catalysis, and biological signaling via cysteine residues and a small molecule, Ebselen
Atomistic modulation of <span>MIF</span> ‐2 structure, catalysis, and biological signaling via cysteine residues and a small molecule, Ebselen Open
The macrophage migration inhibitory factor (MIF) family of cytokines comprised of the MIF and D‐dopachrome tautomerase (or MIF‐2) paralogs share identical tertiary and quaternary structures that contribute to their overlapping enzymatic an…
View article: Bubble NIPPV: Guidelines for Use
Bubble NIPPV: Guidelines for Use Open
Neonatal respiratory distress is a primary contributor to neonatal morbidity and mortality worldwide. Non-invasive respiratory support such as nasal continuous positive airway pressure (NCPAP) and bubble NCPAP (bNCPAP) are often used as th…
View article: Invasive Ventilation Strategies in Neonates
Invasive Ventilation Strategies in Neonates Open
We provide evidence-based recommendations and clinical guidance on strategies for invasive mechanical ventilation in neonates until successful extubation in the neonatal intensive care unit. A systematic search of the PubMed, Embase, and C…
View article: Allosteric Modulation of MIF-2 Structure, Catalysis, and Biological Signaling via Cysteine Residues and a Small Molecule, Ebselen
Allosteric Modulation of MIF-2 Structure, Catalysis, and Biological Signaling via Cysteine Residues and a Small Molecule, Ebselen Open
The macrophage migration inhibitory factor (MIF) family of cytokines comprised of the MIF and D-dopachrome tautomerase (or MIF-2) paralogs share identical tertiary and quaternary structures that contribute to their overlapping enzymatic an…
View article: Inhibition of MIF with an Allosteric Inhibitor Triggers Cell Cycle Arrest in Acute Myeloid Leukemia
Inhibition of MIF with an Allosteric Inhibitor Triggers Cell Cycle Arrest in Acute Myeloid Leukemia Open
Macrophage migration inhibitory factor (MIF) is a key modulator of innate and adaptive immunity that has been extensively reported to promote tumor cell survival, proliferation, and metastasis. A recent study focusing on the microenvironme…
View article: A novel circRNA–miRNA–mRNA regulatory axis as a sex-specific biological variable in bronchopulmonary dysplasia
A novel circRNA–miRNA–mRNA regulatory axis as a sex-specific biological variable in bronchopulmonary dysplasia Open
Babies born prematurely with gestational age <28 weeks usually develop a severe pulmonary complication called Bronchopulmonary Dysplasia (BPD) in response to hyperoxia. BPD is a sexually dimorphic pediatric disease with no curative opti…
View article: Analysis of Maternal and Congenital Syphilis Rates at a New Jersey University Hospital
Analysis of Maternal and Congenital Syphilis Rates at a New Jersey University Hospital Open
Syphilis and congenital syphilis (CS) cases have been rising in the U.S. and internationally since the 2000s. Social factors have been shown to increase the risk of CS transmission. The COVID-19 pandemic may have contributed to increased s…
View article: Hyperoxia-Induced miR-195 Causes Bronchopulmonary Dysplasia in Neonatal Mice
Hyperoxia-Induced miR-195 Causes Bronchopulmonary Dysplasia in Neonatal Mice Open
Background: Exposure to hyperoxia is an important factor in the development of bronchopulmonary dysplasia (BPD) in preterm newborns. MicroRNAs (miRs) have been implicated in the pathogenesis of BPD and provide a potential therapeutic targe…
View article: Analysis of Maternal and Congenital Syphilis Rates at a New Jersey University Hospital
Analysis of Maternal and Congenital Syphilis Rates at a New Jersey University Hospital Open
Objective: To quantify the rise in congenital syphilis (CS) at a large urban hospital and the impact of the COVID-19 pandemic on CS rates. Study Design: Retrospective chart review of 61 pregnant women with a positive test or previous diagn…
View article: Prevalence, Prevention and Management of Bronchopulmonary Dysplasia
Prevalence, Prevention and Management of Bronchopulmonary Dysplasia Open
Bronchopulmonary dysplasia (BPD) is a complex pulmonary condition that arises in preterm infants secondary to a constellation of adverse exposures contributing to impaired lung development and repair. In many developed countries, the incid…
View article: Safety of Bubble Nasal Intermittent Positive Pressure Ventilation (NIPPV) versus Bubble Nasal Continuous Positive Airway Pressure (NCPAP) in preterm infants with respiratory distress
Safety of Bubble Nasal Intermittent Positive Pressure Ventilation (NIPPV) versus Bubble Nasal Continuous Positive Airway Pressure (NCPAP) in preterm infants with respiratory distress Open
Objective Nasal Intermittent Positive Pressure Ventilation (NIPPV) is an effective therapy for infants in respiratory distress. We here report the safety of a novel, low-cost, non-electric bubble NIPPV device in comparison with bubble NCPA…
View article: Incidence of Neonatal Seizures in China Based on Electroencephalogram Monitoring in Neonatal Neurocritical Care Units
Incidence of Neonatal Seizures in China Based on Electroencephalogram Monitoring in Neonatal Neurocritical Care Units Open
Importance Neonatal seizures pose a significant challenge in critical care, and continuous video electroencephalography (cEEG) monitoring holds promise for early detection of seizures. However, large-scale data on the incidence of neonatal…
View article: RDS-NExT workshop: consensus statements for the use of surfactant in preterm neonates with RDS
RDS-NExT workshop: consensus statements for the use of surfactant in preterm neonates with RDS Open
Objective To provide the best clinical practice guidance for surfactant use in preterm neonates with respiratory distress syndrome (RDS). The RDS-Neonatal Expert Taskforce (RDS-NExT) initiative was intended to add to existing evidence and …
View article: Patterns of investment in agricultural research and innovation for the Global South, with a focus on sustainable agricultural intensification
Patterns of investment in agricultural research and innovation for the Global South, with a focus on sustainable agricultural intensification Open
This study is the first attempt to determine global investment patterns for research and innovation in agriculture systems for the Global South, and specifically for innovation funding targeted at sustainable agricultural intensification. …
View article: Nasal intermittent positive pressure ventilation as a rescue therapy after nasal continuous positive airway pressure failure in infants with respiratory distress syndrome
Nasal intermittent positive pressure ventilation as a rescue therapy after nasal continuous positive airway pressure failure in infants with respiratory distress syndrome Open
Objective: Evaluate whether nasal intermittent positive-pressure ventilation (NIPPV) as rescue therapy after initial nasal continuous positive airway (NCPAP) failure reduces need for invasive mechanical ventilation (IMV) in infants with re…
View article: Does Neonatal Sepsis Independently Increase Neurodevelopmental Impairment?
Does Neonatal Sepsis Independently Increase Neurodevelopmental Impairment? Open
Editorial Comment on: Short- and long- term neurodevelopmental outcomes of very preterm infants with neonatal sepsis: a systematic review and meta-analysis [...]
View article: A Cysteine Variant at an Allosteric Site Alters MIF Dynamics and Biological Function in Homo- and Heterotrimeric Assemblies
A Cysteine Variant at an Allosteric Site Alters MIF Dynamics and Biological Function in Homo- and Heterotrimeric Assemblies Open
Macrophage migration inhibitory factor (MIF) is an inflammatory protein with various non-overlapping functions. It is not only conserved in mammals, but it is found in parasites, fish, and plants. Human MIF is a homotrimer with an enzymati…
View article: Redox-dependent Structure and Dynamics of Macrophage Migration Inhibitory Factor Reveal Sites of Latent Allostery
Redox-dependent Structure and Dynamics of Macrophage Migration Inhibitory Factor Reveal Sites of Latent Allostery Open
Macrophage migration inhibitory factor (MIF) is a multifunctional immunoregulatory protein that is a key player in the innate immune response. Given its overexpression at sites of inflammation in a wide range of diseases marked by increasi…