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View article: Distinct Classes of Gut Bacterial Molybdenum-Dependent Enzymes Produce Urolithins
Distinct Classes of Gut Bacterial Molybdenum-Dependent Enzymes Produce Urolithins Open
Urolithin A is an anti-aging and anti-inflammatory gut bacterial metabolite derived from ellagic acid (EA), a polyphenol abundant in berries and nuts. The conversion of EA to urolithin A involves multiple chemically challenging phenol dehy…
View article: Neurospora intermedia from a traditional fermented food enables waste-to-food conversion
Neurospora intermedia from a traditional fermented food enables waste-to-food conversion Open
Fungal fermentation of food and agricultural by-products holds promise for improving food sustainability and security. However, the molecular basis of fungal waste-to-food upcycling remains poorly understood. Here we use a multi-omics appr…
View article: Multi-omics analysis of a traditional fermented food reveals a byproduct-associated subpopulation of<i>Neurospora intermedia</i>for waste-to-food upcycling
Multi-omics analysis of a traditional fermented food reveals a byproduct-associated subpopulation of<i>Neurospora intermedia</i>for waste-to-food upcycling Open
Fungal solid-state fermentation (SSF) of byproducts has promise for increasing food sustainability and security, but fungal waste-to-food upcycling remains poorly understood at the molecular level. Here we use a multi-omics approach to cha…
View article: Edible mycelium bioengineered for enhanced nutritional value and sensory appeal using a modular synthetic biology toolkit
Edible mycelium bioengineered for enhanced nutritional value and sensory appeal using a modular synthetic biology toolkit Open
Filamentous fungi are critical in the transition to a more sustainable food system. While genetic modification of these organisms has promise for enhancing the nutritional value, sensory appeal, and scalability of fungal foods, genetic too…
View article: Synthetic expression system enhances recombinant protein production in Aspergillus oryzae
Synthetic expression system enhances recombinant protein production in Aspergillus oryzae Open
View article: From lab to table: Expanding gastronomic possibilities with fermentation using the edible fungus Neurospora intermedia
From lab to table: Expanding gastronomic possibilities with fermentation using the edible fungus Neurospora intermedia Open
View article: Microbial foods for improving human and planetary health
Microbial foods for improving human and planetary health Open
View article: Synthetic gene expression system enhances recombinant protein production in Aspergillus oryzae
Synthetic gene expression system enhances recombinant protein production in Aspergillus oryzae Open
View article: A Genomic Toolkit for the Mechanistic Dissection of Intractable Human Gut Bacteria
A Genomic Toolkit for the Mechanistic Dissection of Intractable Human Gut Bacteria Open
View article: A widely distributed metalloenzyme class enables gut microbial metabolism of host- and diet-derived catechols
A widely distributed metalloenzyme class enables gut microbial metabolism of host- and diet-derived catechols Open
Catechol dehydroxylation is a central chemical transformation in the gut microbial metabolism of plant- and host-derived small molecules. However, the molecular basis for this transformation and its distribution among gut microorganisms ar…
View article: Author response: A widely distributed metalloenzyme class enables gut microbial metabolism of host- and diet-derived catechols
Author response: A widely distributed metalloenzyme class enables gut microbial metabolism of host- and diet-derived catechols Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods Appendix 1 Data availability References Decision letter Author response Article and author information Metrics Abstract Catechol dehydroxy…
View article: Cooking shapes the structure and function of the gut microbiome
Cooking shapes the structure and function of the gut microbiome Open
View article: A widely distributed metalloenzyme class enables gut microbial metabolism of host- and diet-derived catechols
A widely distributed metalloenzyme class enables gut microbial metabolism of host- and diet-derived catechols Open
Catechol dehydroxylation is a central chemical transformation in the gut microbial metabolism of plant- and host-derived small molecules. However, the molecular basis for this transformation and its distribution among gut microorganisms ar…
View article: Discovery and inhibition of an interspecies gut bacterial pathway for Levodopa metabolism
Discovery and inhibition of an interspecies gut bacterial pathway for Levodopa metabolism Open
The dope on l -dopa metabolism The efficacy of l -dopa treatment for Parkinson's disease is hugely variable between individuals, depending on the composition of their microbiota. l -Dopa is decarboxylated into active dopamine, but if the g…
View article: <i>Clostridioides difficile</i> uses amino acids associated with gut microbial dysbiosis in a subset of patients with diarrhea
<i>Clostridioides difficile</i> uses amino acids associated with gut microbial dysbiosis in a subset of patients with diarrhea Open
Increased amino acids in the dysbiotic gut influences susceptibility to Clostridioides difficile infection in mice and humans.
View article: Illuminating the microbiome’s dark matter: a functional genomic toolkit for the study of human gut Actinobacteria
Illuminating the microbiome’s dark matter: a functional genomic toolkit for the study of human gut Actinobacteria Open
Despite the remarkable evolutionary and metabolic diversity found within the human microbiome, the vast majority of mechanistic studies focus on two phyla: the Bacteroidetes and the Proteobacteria. Generalizable tools for studying the othe…
View article: Gut Microbiota: Rational Manipulation of Gut Bacterial Metalloenzymes Provides Insights into Dysbiosis and Inflammation
Gut Microbiota: Rational Manipulation of Gut Bacterial Metalloenzymes Provides Insights into Dysbiosis and Inflammation Open
ADVERTISEMENT RETURN TO ISSUEPREVViewpointNEXTGut Microbiota: Rational Manipulation of Gut Bacterial Metalloenzymes Provides Insights into Dysbiosis and InflammationVayu M. RekdalVayu M. RekdalDepartment of Chemistry and Chemical Biology, …
View article: Chemical transformation of xenobiotics by the human gut microbiota
Chemical transformation of xenobiotics by the human gut microbiota Open
One person's meat is another's poison The human gut is packed with actively metabolizing microorganisms. These have a transformative effect on what we ingest—whether food, drugs, or pollutants. Koppel et al. review the distinguishing featu…