Velda X. Han
YOU?
Author Swipe
View article: IV Immunoglobulin Is Associated With Epigenetic, Ribosomal, and Immune Changes in Pediatric Acute-Onset Neuropsychiatric Syndrome
IV Immunoglobulin Is Associated With Epigenetic, Ribosomal, and Immune Changes in Pediatric Acute-Onset Neuropsychiatric Syndrome Open
We propose that PANS is an epigenetic immune brain disorder with cellular epigenetic, ribosomal, and immune dysregulation. Epigenetic and immune-modulating therapies, such as IVIg, may have disease-modifying effects.
View article: Epigenetic, ribosomal, and immune dysregulation in paediatric acute-onset neuropsychiatric syndrome
Epigenetic, ribosomal, and immune dysregulation in paediatric acute-onset neuropsychiatric syndrome Open
View article: Single‐Cell <scp>RNA</scp> Seq in Sydenham Chorea Shows B Cell <i>HLA‐DR/DQ</i> Upregulation and Plasma Cell Proteasomal Activation
Single‐Cell <span>RNA</span> Seq in Sydenham Chorea Shows B Cell <i>HLA‐DR/DQ</i> Upregulation and Plasma Cell Proteasomal Activation Open
The pathogenesis of Sydenham chorea remains unclear. We report a 10‐year‐old girl presenting with subacute chorea and mild carditis following Streptococcal throat infection. Single‐cell RNA sequencing on 30,794 peripheral immune cells from…
View article: Butyrate modifies epigenetic and immune pathways in peripheral mononuclear cells from children with neurodevelopmental disorders associated with chromatin dysregulation
Butyrate modifies epigenetic and immune pathways in peripheral mononuclear cells from children with neurodevelopmental disorders associated with chromatin dysregulation Open
Pathogenic DNA variants in chromatin-related genes cause an important minority of neurodevelopmental disorders (NDDs). Epigenetic mechanisms, including chromatin regulation, are associated with NDD etiopathogenesis. Therapeutic strategies …
View article: Medicinal Cannabis Plant Extract (NTI164) modifies epigenetic, ribosomal, and immune pathways in paediatric acute-onset neuropsychiatric syndrome
Medicinal Cannabis Plant Extract (NTI164) modifies epigenetic, ribosomal, and immune pathways in paediatric acute-onset neuropsychiatric syndrome Open
Background Paediatric acute-onset neuropsychiatric syndrome (PANS) is a syndrome of infection-provoked abrupt-onset obsessive-compulsive disorder (OCD) or eating restriction. Based on the hypothesis that PANS is an epigenetic disorder of i…
View article: A Toddler With New Onset Poor Sleep, Irritability and Head Banging
A Toddler With New Onset Poor Sleep, Irritability and Head Banging Open
View article: NDD-ECHO: A standardised digital assessment tool to capture early life environmental and inflammatory factors for children with neurodevelopmental disorders
NDD-ECHO: A standardised digital assessment tool to capture early life environmental and inflammatory factors for children with neurodevelopmental disorders Open
Neurodevelopmental disorders (NDDs), such as autism spectrum disorder (ASD), attention-deficit hyperactivity disorder (ADHD), obsessive-compulsive disorder (OCD), and Tourette syndrome are highly prevalent in childhood and are influenced b…
View article: Genetic testing in cerebral palsy with clinical and neuroimaging variables
Genetic testing in cerebral palsy with clinical and neuroimaging variables Open
Aim To optimize genetic testing in children with cerebral palsy (CP) by using clinical and magnetic resonance imaging (MRI) variables. Method In this mixed methods study, we surveyed current approaches to genetic testing by Australian clin…
View article: Epigenetic, ribosomal, and immune dysregulation in Paediatric Acute-Onset Neuropsychiatric Syndrome
Epigenetic, ribosomal, and immune dysregulation in Paediatric Acute-Onset Neuropsychiatric Syndrome Open
Paediatric Acute-Onset Neuropsychiatric Syndrome (PANS) is characterised by abrupt onset obsessive compulsive disorder and regression in neurodevelopmental skills, triggered by infection or stress. Whether PANS is a distinct entity or part…
View article: Intravenous immunoglobulin has epigenetic, ribosomal, and immune effects in Paediatric Acute-Onset Neuropsychiatric Syndrome
Intravenous immunoglobulin has epigenetic, ribosomal, and immune effects in Paediatric Acute-Onset Neuropsychiatric Syndrome Open
Paediatric acute-onset neuropsychiatric syndrome (PANS) is characterised by infection-provoked abrupt and dramatic onset of obsessive compulsive disorder (OCD) or eating restriction, along with neurodevelopmental regression. Although the a…
View article: Cerebrospinal fluid metabolomics in autistic regression reveals dysregulation of sphingolipids and decreased β-hydroxybutyrate
Cerebrospinal fluid metabolomics in autistic regression reveals dysregulation of sphingolipids and decreased β-hydroxybutyrate Open
Financial support for the study was granted by Dale NHMRC Investigator grant APP1193648, Petre Foundation, Cerebral Palsy Alliance, and Ainsworth and SCHF Neuroscience grant scheme.
View article: Cumulative pregnancy and postnatal environmental exposures impact social behaviour in male mice associated with epigenetic, ribosomal, and immune dysregulation
Cumulative pregnancy and postnatal environmental exposures impact social behaviour in male mice associated with epigenetic, ribosomal, and immune dysregulation Open
Environmental exposures across critical developmental windows can significantly influence brain development and contribute to the pathogenesis of neurodevelopmental disorders (NDDs). Emerging clinical evidence suggests that cumulative envi…
View article: Single-Cell RNA Sequencing in Incontinentia Pigmenti With Neonatal Encephalopathy Reveals Broad Immune Activation Moderated by Steroids
Single-Cell RNA Sequencing in Incontinentia Pigmenti With Neonatal Encephalopathy Reveals Broad Immune Activation Moderated by Steroids Open
IP-associated loss of NEMO function is associated with a proinflammatory phenotype, that is moderated by steroids. scRNAseq provides a rationale for immune modulation in an n = 1 setting and valuable insights into the pathogenesis a…
View article: Aetiopathogenesis of infantile epileptic spasms syndrome and mechanisms of action of adrenocorticotrophin hormone/corticosteroids in children: A scoping review
Aetiopathogenesis of infantile epileptic spasms syndrome and mechanisms of action of adrenocorticotrophin hormone/corticosteroids in children: A scoping review Open
Aim To review the aetiopathogenesis of infantile epileptic spasms syndrome (IESS) and mechanisms of action of adrenocorticotrophin hormone (ACTH)/corticosteroids established in humans. Method MEDLINE, PubMed, and Embase were systematically…
View article: Pathogenic variants in chromatin‐related genes: Linking immune dysregulation to neuroregression and acute neuropsychiatric disorders
Pathogenic variants in chromatin‐related genes: Linking immune dysregulation to neuroregression and acute neuropsychiatric disorders Open
We report eight children with de novo pathogenic DNA variants in chromatin‐related genes: MORC2, CHD7, KANSL1, KMT2D, ZMYND11, HIST1HIE, EP300, and KMT2B . All children experienced infection or vaccine‐provoked neuroregression or abrupt‐on…
View article: International consensus definitions for infection‐triggered encephalopathy syndromes
International consensus definitions for infection‐triggered encephalopathy syndromes Open
Aim To develop standardized diagnostic criteria for ‘infection‐triggered encephalopathy syndrome (ITES)’ and five specific clinical syndromes of ITES. Method The draft definitions were based on existing criteria, standardized, and discusse…
View article: Ketogenic diet modifies ribosomal protein dysregulation in KMT2D Kabuki syndrome
Ketogenic diet modifies ribosomal protein dysregulation in KMT2D Kabuki syndrome Open
View article: Association between cumulative maternal exposures related to inflammation and child attention‐deficit/hyperactivity disorder: A cohort study
Association between cumulative maternal exposures related to inflammation and child attention‐deficit/hyperactivity disorder: A cohort study Open
Background Preclinical studies suggest synergistic effects of maternal inflammatory exposures on offspring neurodevelopment, but human studies have been limited. Objectives To examine the cumulative association and potential interactions b…
View article: <scp>CSF</scp> neopterin and quinolinic acid are biomarkers of neuroinflammation and neurotoxicity in <scp>FIRES</scp> and other infection‐triggered encephalopathy syndromes
<span>CSF</span> neopterin and quinolinic acid are biomarkers of neuroinflammation and neurotoxicity in <span>FIRES</span> and other infection‐triggered encephalopathy syndromes Open
Objective Infection‐triggered encephalopathy syndromes (ITES) are potentially devastating neuroinflammatory conditions. Although some ITES syndromes have recognisable MRI neuroimaging phenotypes, there are otherwise few biomarkers of disea…
View article: Sublingual ondansetron for treatment of acute gastroenteritis in children in the children’s emergency
Sublingual ondansetron for treatment of acute gastroenteritis in children in the children’s emergency Open
View article: CSF neopterin, quinolinic acid and kynurenine/tryptophan ratio are biomarkers of active neuroinflammation
CSF neopterin, quinolinic acid and kynurenine/tryptophan ratio are biomarkers of active neuroinflammation Open
View article: Common targetable inflammatory pathways in brain transcriptome of autism spectrum disorders and Tourette syndrome
Common targetable inflammatory pathways in brain transcriptome of autism spectrum disorders and Tourette syndrome Open
Neurodevelopmental disorders (NDDs), including autism-spectrum disorders (ASD) and Tourette syndrome (TS) are common brain conditions which often co-exist, and have no approved treatments targeting disease mechanisms. Accumulating literatu…
View article: SARS-CoV-2-Related Acute Necrotizing Encephalopathy of Childhood With Good Response to Tocilizumab in an Adolescent
SARS-CoV-2-Related Acute Necrotizing Encephalopathy of Childhood With Good Response to Tocilizumab in an Adolescent Open
View article: Association of maternal autoimmune disease and early childhood infections with offspring autism spectrum disorder: A population‐based cohort study
Association of maternal autoimmune disease and early childhood infections with offspring autism spectrum disorder: A population‐based cohort study Open
The aim of this study was to examine potential synergistic effects between maternal autoimmune disease and early childhood infections and their association with autism spectrum disorder (ASD) in offspring. Both exposures have been associat…
View article: Decreased cerebrospinal fluid kynurenic acid in epileptic spasms: A biomarker of response to corticosteroids
Decreased cerebrospinal fluid kynurenic acid in epileptic spasms: A biomarker of response to corticosteroids Open
View article: Rapid onset functional tic‐like behaviours in children and adolescents during <scp>COVID</scp>‐19: Clinical features, assessment and biopsychosocial treatment approach
Rapid onset functional tic‐like behaviours in children and adolescents during <span>COVID</span>‐19: Clinical features, assessment and biopsychosocial treatment approach Open
Aim To report the prevalence and clinical characteristics of children with rapid onset functional tic‐like behaviours during the COVID‐19 pandemic. Methods Single centre, retrospective cohort study of children (<18 years) referred to the t…
View article: Development of a translational inflammation panel for the quantification of cerebrospinal fluid Pterin, Tryptophan-Kynurenine and Nitric oxide pathway metabolites
Development of a translational inflammation panel for the quantification of cerebrospinal fluid Pterin, Tryptophan-Kynurenine and Nitric oxide pathway metabolites Open
View article: Brain Transcriptome of Autism Spectrum Disorders and Tourette Syndrome Defines Common Targetable Inflammatory Pathways Involving Cytokines, Complement, and Kinase Signalling
Brain Transcriptome of Autism Spectrum Disorders and Tourette Syndrome Defines Common Targetable Inflammatory Pathways Involving Cytokines, Complement, and Kinase Signalling Open
Background Neurodevelopmental disorders (NDDs), including autism-spectrum disorders (ASD) and Tourette syndrome (TS) are common brain conditions which often co-exist, however current management focuses on symptom mitigation, with no approv…
View article: Cerebrospinal fluid neopterin as a biomarker of treatment response to Janus kinase inhibition in Aicardi–Goutières syndrome
Cerebrospinal fluid neopterin as a biomarker of treatment response to Janus kinase inhibition in Aicardi–Goutières syndrome Open
Janus kinase (JAK) 1 inhibition represents a precision medicine approach in the treatment of Aicardi–Goutières syndrome (AGS), through targeting of type I interferon‐mediated cell signalling. Blood interferon mRNAseq has been proposed as a…
View article: Maternal acute and chronic inflammation in pregnancy is associated with common neurodevelopmental disorders: a systematic review
Maternal acute and chronic inflammation in pregnancy is associated with common neurodevelopmental disorders: a systematic review Open
Inflammation is increasingly recognized as a cause or consequence of common problems of humanity including obesity, stress, depression, pollution and disease states such as autoimmunity, asthma, and infection. Maternal immune activation (M…