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View article: Decrease in dose per fraction impairs the FLASH sparing effect in murine intestine model
Decrease in dose per fraction impairs the FLASH sparing effect in murine intestine model Open
In an acute responding model of radiation-induced abdominal toxicity, the FLASH sparing effect was substantially reduced with a two-fraction regimen and completely absent with a ten-fraction regimen. These findings suggest that the benefit…
View article: Radiochromic film dosimetry for VHEE and UHDR: protocol adaptation and verification at the CLEAR facility
Radiochromic film dosimetry for VHEE and UHDR: protocol adaptation and verification at the CLEAR facility Open
Radiochromic films (RCFs) offer effective two-dimensional dosimetry with a simple, low-cost operating principle, making them suitable for very high-energy electron (VHEE) and ultra-high dose rate (UHDR) applications, where dosimetry standa…
View article: Decrease in dose per fraction impairs the FLASH sparing effect in murine intestine model
Decrease in dose per fraction impairs the FLASH sparing effect in murine intestine model Open
Purpose FLASH radiotherapy (FLASH) can ease radiation-induced normal tissue toxicities; however, its benefit in clinically relevant fractionation protocols remains insufficiently explored. This study investigated the FLASH sparing effect u…
View article: Differentiating unirradiated mice from those exposed to conventional or FLASH radiotherapy using MRI
Differentiating unirradiated mice from those exposed to conventional or FLASH radiotherapy using MRI Open
Background and purpose The FLASH effect expands the therapeutic ratio of tumor control to normal tissue toxicity observed after delivery of ultra-high (>100 Gy/s FLASH-RT) vs. conventional dose rate radiation (CONV-RT). In this first explo…
View article: Innovation in Radiotherapy: FLASH Therapy
Innovation in Radiotherapy: FLASH Therapy Open
FLASH radiotherapy (RT) is a new form of RT delivering the dose in milliseconds instead of minutes for conventional RT. This FLASH RT appears much less toxic on normal tissues while the effect on tumors is maintained intact or even improve…
View article: Decrease in dose per fraction impairs the FLASH sparing effect in murine intestine model
Decrease in dose per fraction impairs the FLASH sparing effect in murine intestine model Open
View article: Decrease in dose per fraction impairs the FLASH sparing effect in murine intestine model
Decrease in dose per fraction impairs the FLASH sparing effect in murine intestine model Open
View article: Decrease in dose per fraction impairs the FLASH sparing effect in murine intestine model
Decrease in dose per fraction impairs the FLASH sparing effect in murine intestine model Open
View article: In vivo measurements of change in tissue oxygen level during irradiation reveal novel dose rate dependence
In vivo measurements of change in tissue oxygen level during irradiation reveal novel dose rate dependence Open
View article: Active dosimetry for VHEE FLASH radiotherapy using beam profile monitors and charge measurements
Active dosimetry for VHEE FLASH radiotherapy using beam profile monitors and charge measurements Open
View article: Average dose rate is the primary determinant of lipid peroxidation in liposome membranes exposed to pulsed electron FLASH beam
Average dose rate is the primary determinant of lipid peroxidation in liposome membranes exposed to pulsed electron FLASH beam Open
Lipid peroxidation, a self-propagating chain reaction that oxydates lipid molecules, contributes to harmful effects of ionizing radiation. A decrease in peroxidation at higher dose rates could play a role in the FLASH sparing effect. We ex…
View article: Multi-Institutional Audit of FLASH and Conventional Dosimetry With a 3D Printed Anatomically Realistic Mouse Phantom
Multi-Institutional Audit of FLASH and Conventional Dosimetry With a 3D Printed Anatomically Realistic Mouse Phantom Open
View article: Acute Hypoxia Does Not Alter Tumor Sensitivity to FLASH Radiation Therapy
Acute Hypoxia Does Not Alter Tumor Sensitivity to FLASH Radiation Therapy Open
These data provide new and specific insights showing the efficacy of FLASH in a radiation-resistant context, proving an additional benefit of FLASH over CONV.
View article: Average Dose Rate is the Primary Determinant of Lipid Peroxidation in Liposome Membranes Exposed to Pulsed Electron Beam
Average Dose Rate is the Primary Determinant of Lipid Peroxidation in Liposome Membranes Exposed to Pulsed Electron Beam Open
View article: Antitumor Effect by Either FLASH or Conventional Dose Rate Irradiation Involves Equivalent Immune Responses
Antitumor Effect by Either FLASH or Conventional Dose Rate Irradiation Involves Equivalent Immune Responses Open
View article: Dosimetric and biologic intercomparison between electron and proton FLASH beams
Dosimetric and biologic intercomparison between electron and proton FLASH beams Open
Despite major differences in the temporal microstructure of proton and electron beams, this study shows that dosimetric standards can be established. Normal brain protection and tumor control were produced by the two beams. More specifical…
View article: Multi-Institutional Audit of FLASH and Conventional Dosimetry with a 3D-Printed Anatomically Realistic Mouse Phantom
Multi-Institutional Audit of FLASH and Conventional Dosimetry with a 3D-Printed Anatomically Realistic Mouse Phantom Open
We conducted a multi-institutional audit of dosimetric variability between FLASH and conventional dose rate (CONV) electron irradiations by using an anatomically realistic 3D-printed mouse phantom. A CT scan of a live mouse was used to cre…
View article: Construction and dosimetric characterization of a motorized scanning‐slit system for electron FLASH experiments
Construction and dosimetric characterization of a motorized scanning‐slit system for electron FLASH experiments Open
Background Beam scanning is a useful technique for the treatment of large tumors when the primary beam size is limited, which is the case with radiation beams used in FLASH radiotherapy. Purpose To optimize beam scanning as a dose delivery…
View article: The sparing effect of FLASH-RT on synaptic plasticity is maintained in mice with standard fractionation
The sparing effect of FLASH-RT on synaptic plasticity is maintained in mice with standard fractionation Open
View article: Proton and alpha radiation-induced mutational profiles in human cells
Proton and alpha radiation-induced mutational profiles in human cells Open
Ionizing radiation is known to be DNA damaging and mutagenic, however less is known about which mutational footprints result from exposures of human cells to different types of radiation. We were interested in the mutagenic effects of part…
View article: Dosimetric and biologic intercomparison between electron and proton FLASH beams
Dosimetric and biologic intercomparison between electron and proton FLASH beams Open
Background and purpose The FLASH effect has been validated in different preclinical experiments with electrons (eFLASH) and protons (pFLASH) operating at a mean dose rate above 40 Gy/s. However, no systematic intercomparison of the FLASH e…
View article: Supplementary Table from Dose- and Volume-Limiting Late Toxicity of FLASH Radiotherapy in Cats with Squamous Cell Carcinoma of the Nasal Planum and in Mini Pigs
Supplementary Table from Dose- and Volume-Limiting Late Toxicity of FLASH Radiotherapy in Cats with Squamous Cell Carcinoma of the Nasal Planum and in Mini Pigs Open
Supplementary Table from Dose- and Volume-Limiting Late Toxicity of FLASH Radiotherapy in Cats with Squamous Cell Carcinoma of the Nasal Planum and in Mini Pigs
View article: Supplementary Table from Dose- and Volume-Limiting Late Toxicity of FLASH Radiotherapy in Cats with Squamous Cell Carcinoma of the Nasal Planum and in Mini Pigs
Supplementary Table from Dose- and Volume-Limiting Late Toxicity of FLASH Radiotherapy in Cats with Squamous Cell Carcinoma of the Nasal Planum and in Mini Pigs Open
Supplementary Table from Dose- and Volume-Limiting Late Toxicity of FLASH Radiotherapy in Cats with Squamous Cell Carcinoma of the Nasal Planum and in Mini Pigs
View article: Data from Dose- and Volume-Limiting Late Toxicity of FLASH Radiotherapy in Cats with Squamous Cell Carcinoma of the Nasal Planum and in Mini Pigs
Data from Dose- and Volume-Limiting Late Toxicity of FLASH Radiotherapy in Cats with Squamous Cell Carcinoma of the Nasal Planum and in Mini Pigs Open
Purpose:The FLASH effect is characterized by normal tissue sparing without compromising tumor control. Although demonstrated in various preclinical models, safe translation of FLASH-radiotherapy stands to benefit from larger vertebrate ani…
View article: Supplementary Table from Dose- and Volume-Limiting Late Toxicity of FLASH Radiotherapy in Cats with Squamous Cell Carcinoma of the Nasal Planum and in Mini Pigs
Supplementary Table from Dose- and Volume-Limiting Late Toxicity of FLASH Radiotherapy in Cats with Squamous Cell Carcinoma of the Nasal Planum and in Mini Pigs Open
Supplementary Table from Dose- and Volume-Limiting Late Toxicity of FLASH Radiotherapy in Cats with Squamous Cell Carcinoma of the Nasal Planum and in Mini Pigs
View article: Supplementary Figure from Dose- and Volume-Limiting Late Toxicity of FLASH Radiotherapy in Cats with Squamous Cell Carcinoma of the Nasal Planum and in Mini Pigs
Supplementary Figure from Dose- and Volume-Limiting Late Toxicity of FLASH Radiotherapy in Cats with Squamous Cell Carcinoma of the Nasal Planum and in Mini Pigs Open
Supplementary Figure from Dose- and Volume-Limiting Late Toxicity of FLASH Radiotherapy in Cats with Squamous Cell Carcinoma of the Nasal Planum and in Mini Pigs
View article: Supplementary Figure from Dose- and Volume-Limiting Late Toxicity of FLASH Radiotherapy in Cats with Squamous Cell Carcinoma of the Nasal Planum and in Mini Pigs
Supplementary Figure from Dose- and Volume-Limiting Late Toxicity of FLASH Radiotherapy in Cats with Squamous Cell Carcinoma of the Nasal Planum and in Mini Pigs Open
Supplementary Figure from Dose- and Volume-Limiting Late Toxicity of FLASH Radiotherapy in Cats with Squamous Cell Carcinoma of the Nasal Planum and in Mini Pigs
View article: Supplementary Figure from Dose- and Volume-Limiting Late Toxicity of FLASH Radiotherapy in Cats with Squamous Cell Carcinoma of the Nasal Planum and in Mini Pigs
Supplementary Figure from Dose- and Volume-Limiting Late Toxicity of FLASH Radiotherapy in Cats with Squamous Cell Carcinoma of the Nasal Planum and in Mini Pigs Open
Supplementary Figure from Dose- and Volume-Limiting Late Toxicity of FLASH Radiotherapy in Cats with Squamous Cell Carcinoma of the Nasal Planum and in Mini Pigs
View article: Supplementary Figure from Dose- and Volume-Limiting Late Toxicity of FLASH Radiotherapy in Cats with Squamous Cell Carcinoma of the Nasal Planum and in Mini Pigs
Supplementary Figure from Dose- and Volume-Limiting Late Toxicity of FLASH Radiotherapy in Cats with Squamous Cell Carcinoma of the Nasal Planum and in Mini Pigs Open
Supplementary Figure from Dose- and Volume-Limiting Late Toxicity of FLASH Radiotherapy in Cats with Squamous Cell Carcinoma of the Nasal Planum and in Mini Pigs
View article: Supplementary Figure from Dose- and Volume-Limiting Late Toxicity of FLASH Radiotherapy in Cats with Squamous Cell Carcinoma of the Nasal Planum and in Mini Pigs
Supplementary Figure from Dose- and Volume-Limiting Late Toxicity of FLASH Radiotherapy in Cats with Squamous Cell Carcinoma of the Nasal Planum and in Mini Pigs Open
Supplementary Figure from Dose- and Volume-Limiting Late Toxicity of FLASH Radiotherapy in Cats with Squamous Cell Carcinoma of the Nasal Planum and in Mini Pigs