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View article: Li Fraumeni syndrome presenting atypically as Immune thrombocytopenia and early aging phenotype-A case report
Li Fraumeni syndrome presenting atypically as Immune thrombocytopenia and early aging phenotype-A case report Open
Background: Germline mutations in the TP53 gene are primarily associated with Li-Fraumeni syndrome (LFS), a hereditary cancer predisposition disorder. While the predominant manifestations are various malignancies, there is limited informat…
View article: Hematopoietic Stem Cell Transplant for Acute Myeloid Leukaemia in Children and Adolescents: Multicentric Experience from India
Hematopoietic Stem Cell Transplant for Acute Myeloid Leukaemia in Children and Adolescents: Multicentric Experience from India Open
Introduction: Hematopoietic stem cell transplantation (HSCT) is a curative approach in patients with high-risk Acute Myeloid Leukaemia (AML)/MDS. This multicentric retrospective analysis aimed to investigate outcomes and risk factors assoc…
View article: Sequential Occurrence of Eosinophilic Gastrointestinal Disease in a Case of Waldenström’s Macroglobulinemia in Remission: An Unusual Report with Review
Sequential Occurrence of Eosinophilic Gastrointestinal Disease in a Case of Waldenström’s Macroglobulinemia in Remission: An Unusual Report with Review Open
Waldenström macroglobulinemia (WM) is a rare lymphoproliferative malignancy presenting with para-proteinemia. The symptoms are attributable to both lymphoproliferation and IgM flare. Gastrointestinal manifestations are not uncommon. It is …
View article: An approach for control of equilibrium field profile through the real-time plasma current in ADITYA-U and SST-1 tokamaks
An approach for control of equilibrium field profile through the real-time plasma current in ADITYA-U and SST-1 tokamaks Open
Pairs of external magnetic field coils placed outside the vessel maintain plasma equilibrium in tokamaks. The shape and position of the plasma column are determined and controlled by the temporal current profile in the external field coils…
View article: Prevalence of MGUS in Rural Indian Population: Results of Simple (IMAGe-002A) Study
Prevalence of MGUS in Rural Indian Population: Results of Simple (IMAGe-002A) Study Open
Introduction: The incidence of monoclonal gammopathies is rising across the globe. Although the prevalence of monoclonal gammopathy of undetermined significance (MGUS) has been evaluated in two hospital-based studies in India, no data exis…
View article: Normative Data of Beta-2-Microglobulin and Plasma Proteins from an Agrarian Indian Community By a Door-to-Door Survey: Results of Simple (IMAGe-002B) Study
Normative Data of Beta-2-Microglobulin and Plasma Proteins from an Agrarian Indian Community By a Door-to-Door Survey: Results of Simple (IMAGe-002B) Study Open
Introduction: Most diagnostic laboratories in India follow the reference intervals given in Western literature whose Caucasian reference population is entirely different from the Indian ethnic population (viz., dietary habits, lifestyle, s…
View article: Clinico-laboratory Profile and Outcomes of Megaloblastic Anemia presenting as Severe Pyrexial Illness mimicking Tropical Infection
Clinico-laboratory Profile and Outcomes of Megaloblastic Anemia presenting as Severe Pyrexial Illness mimicking Tropical Infection Open
Background: Anemia-causing fever has been described in patients with megaloblastic anemia. Although the exact mechanism of this is unknown, high-grade fever is relatively less reported. Materials and methods: This prospective observational…
View article: Radiographical Spectrum of High-altitude Pulmonary Edema: A Pictorial Essay
Radiographical Spectrum of High-altitude Pulmonary Edema: A Pictorial Essay Open
Yanamandra U, Vardhan V, Saxena P, Singh P, Gupta A, Mulajkar D, et al. Radiographical Spectrum of High-altitude Pulmonary Edema: A Pictorial Essay. Indian J Crit Care Med 2021;25(6):668-674.
View article: Survival Outcomes of Newly Diagnosed Multiple Myeloma at a Tertiary Care Center in North India (IMAGe: 001A Study)
Survival Outcomes of Newly Diagnosed Multiple Myeloma at a Tertiary Care Center in North India (IMAGe: 001A Study) Open
PURPOSE The outcomes of patients with myeloma from developing countries are often lacking because of poor record maintenance. Publications from such settings are also limited because of the retrospective nature of the data collection. Info…
View article: Safety and efficacy of azathioprine in immune thrombocytopenia.
Safety and efficacy of azathioprine in immune thrombocytopenia. Open
We conclude that azathioprine has a good response rate in chronic ITP patients. It is well-tolerated with minimal and manageable side effects.
View article: Safety and efficacy of splenectomy in immune thrombocytopenia.
Safety and efficacy of splenectomy in immune thrombocytopenia. Open
Splenectomy in ITP offers a long-term sustained response at an economical cost.
View article: Is the clinicopathological profile of dengue syndrome changing?: a 6 year study of different epidemics at a tertiary care center in India
Is the clinicopathological profile of dengue syndrome changing?: a 6 year study of different epidemics at a tertiary care center in India Open
Background: As an arthropod-borne viral disease, dengue epidemics has created much public health hazards in tropical countries. In the national capital of India, there has been more than six epidemics. Dengue remains a notifiable disease i…
View article: Real-world experience of eltrombopag in immune thrombocytopenia.
Real-world experience of eltrombopag in immune thrombocytopenia. Open
Immune thrombocytopenia (ITP) is characterized by decreased platelet count in the peripheral circulation. The first-line therapy is corticosteroids with 53-80% overall response rate. Eltrombopag has been used as second-line therapy in ITP …
View article: Mononuclear cell evaluation: A correlation study between manual and analyzer-based estimation
Mononuclear cell evaluation: A correlation study between manual and analyzer-based estimation Open
Background: Bone marrow transplantation (BMT) is being routinely done at the Army Hospital for the past 15 years. Our experience with Stem Cell Transplantation and clinical trial on stem cell efficacy, our Centre had brought out the issue …
View article: Venous thrombosis at altitude presents with distinct biochemical profiles: a comparative study from the Himalayas to the plains
Venous thrombosis at altitude presents with distinct biochemical profiles: a comparative study from the Himalayas to the plains Open
Key Points HA exposure alters hemostatic systems and contributes to the onset of VTE at a younger age. Aggravated disruption of coagulation, platelet, and endothelial function differentiates HA-induced VTE from VTE on the plains.
View article: High-altitude pulmonary oedema
High-altitude pulmonary oedema Open
Background & objectives: High-altitude pulmonary oedema (HAPE) continues to challenge the healthcare providers at remote, resource-constrained settings. High-altitude terrain itself precludes convenience of resources. This study was conduc…
View article: Development and characterization of human iPSC line NCCSi004-A from umbilical cord blood (UCB) derived CD34+cells obtained from donor belonging to Indian ethnic population
Development and characterization of human iPSC line NCCSi004-A from umbilical cord blood (UCB) derived CD34+cells obtained from donor belonging to Indian ethnic population Open
Here we report the reprogramming of CD34+ cells obtained from UCB of a healthy donor female child belonging to the Indian ethnic population. These CD34+cells were subjected to nucleofection for delivery of episomal vectors expressing Oct4,…
View article: Ocular manifestations of myeloma with coexistent autosomal dominant polycystic kidney disease in a young female
Ocular manifestations of myeloma with coexistent autosomal dominant polycystic kidney disease in a young female Open
Multiple myeloma is a clonal B-cell disease of proliferating plasma cells that rarely involves the eye. On the contrary, renal involvement is frequently seen in myeloma. At the time of diagnosis, about 30%–40% of patients with myeloma have…
View article: Establishing reference ranges and normal values for coagulation screening in healthy Indian male volunteers enrolled for a longitudinal study
Establishing reference ranges and normal values for coagulation screening in healthy Indian male volunteers enrolled for a longitudinal study Open
Background: The study was designed for establishing reference ranges and normal values for coagulation screening in healthy Indian male volunteers. At present, there are no standard parameters established for coagulation screening assays o…
View article: Bedside Ultrasonography as an Alternative to Computed Tomography Scan for the Measurement of Optic Nerve Sheath Diameter
Bedside Ultrasonography as an Alternative to Computed Tomography Scan for the Measurement of Optic Nerve Sheath Diameter Open
Background: Optic nerve sheath diameter (ONSD) as measured by optic nerve sheath ultrasonography (ONSU) is used as a surrogate marker of intracranial pressure (ICP), especially in resource-limited settings. There is a growing interest in t…
View article: Comparison of Optic Nerve Sheath Diameter between both eyes: A Bedside Ultrasonography Approach
Comparison of Optic Nerve Sheath Diameter between both eyes: A Bedside Ultrasonography Approach Open
Our results suggest that the difference in ONSD of both eyes is not statistically significant in disease or health. This study also suggests that the ONSD of either eye can be predicted by the other eye recordings. Based on these findings,…