Venessa Chin
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View article: C1orf50 Accelerates Epithelial-Mesenchymal Transition and the Cell Cycle of Hepatocellular Carcinoma
C1orf50 Accelerates Epithelial-Mesenchymal Transition and the Cell Cycle of Hepatocellular Carcinoma Open
C1orf50 is a novel biomarker of poor prognosis in HCC and a key regulator of oncogenic features such as EMT, cell cycle progression, and stemness. This study highlights the therapeutic potential of targeting C1orf50-related networks in agg…
View article: Protein translation dysregulation and immune cell evasion mediated by IFN and immunoproteasome downregulation define metastatic clones in HPV-related cancer of the oropharynx
Protein translation dysregulation and immune cell evasion mediated by IFN and immunoproteasome downregulation define metastatic clones in HPV-related cancer of the oropharynx Open
View article: Long‐Term Outcomes and Toxicities in Patients With Metastatic Non‐Small Cell Lung Cancer Treated With Immunotherapy Containing Regimens
Long‐Term Outcomes and Toxicities in Patients With Metastatic Non‐Small Cell Lung Cancer Treated With Immunotherapy Containing Regimens Open
Introduction Immunotherapy is well‐established in treating metastatic non‐small cell lung cancer (mNSCLC); however, data regarding acquired resistance and long‐term outcomes are limited. We examined long‐term outcomes in mNSCLC patients wi…
View article: Genetic regulation of cell type–specific chromatin accessibility shapes immune function and disease risk
Genetic regulation of cell type–specific chromatin accessibility shapes immune function and disease risk Open
Understanding how genetic variation influences gene regulation at the single-cell level is crucial for elucidating the mechanisms underlying complex diseases. However, limited large-scale single-cell multi-omics data have constrained our u…
View article: C1orf50 Drives Malignant Melanoma Progression Through the Regulation of Stemness
C1orf50 Drives Malignant Melanoma Progression Through the Regulation of Stemness Open
This study is the first to identify C1orf50 as a prognostic biomarker in melanoma. The clinical relevance of our results sheds light on the importance of further investigation into the biological mechanisms underpinning C1orf50's im…
View article: Changes in adrenoceptor expression level contribute to the cellular plasticity of glioblastoma cells
Changes in adrenoceptor expression level contribute to the cellular plasticity of glioblastoma cells Open
Glioblastoma cells are known to regulate their cellular plasticity in response to their surrounding microenvironment, but it is not fully understood what factors contribute to the cells' changing plasticity. Here, we found that glioblastom…
View article: Impact of COVID-19 on lung cancer care in New South Wales, Australia: real-world data from the EnRICH Program
Impact of COVID-19 on lung cancer care in New South Wales, Australia: real-world data from the EnRICH Program Open
This analysis found that the COVID-19 pandemic did not significantly adversely affect quality of care and outcomes for patients with lung cancer in NSW. Reassuringly, these results suggest that prioritising urgent health services, such as …
View article: ALKTERNATE: A Pilot Study Alternating Lorlatinib With Crizotinib in ALK-Positive NSCLC With Prior ALK Inhibitor Resistance
ALKTERNATE: A Pilot Study Alternating Lorlatinib With Crizotinib in ALK-Positive NSCLC With Prior ALK Inhibitor Resistance Open
ALKTERNATE revealed feasibility with a novel alternating ALK inhibitor strategy in ALK-positive NSCLC. Results support progressing inquiry into this approach and propose a flexible design with drug(s) selected and alternating time frames, …
View article: Adult-type diffuse gliomas share recurring cell states driven by a common astrocyte-like glioma stem cell population
Adult-type diffuse gliomas share recurring cell states driven by a common astrocyte-like glioma stem cell population Open
Summary Adult-type diffuse gliomas are a family of aggressive brain tumours with few effective treatments. Their complex cellular makeup adds to the challenge of finding successful therapies. This intratumoural heterogeneity is fuelled by …
View article: Sacituzumab Govitecan Versus Docetaxel for Previously Treated Advanced or Metastatic Non–Small Cell Lung Cancer: The Randomized, Open-Label Phase III EVOKE-01 Study
Sacituzumab Govitecan Versus Docetaxel for Previously Treated Advanced or Metastatic Non–Small Cell Lung Cancer: The Randomized, Open-Label Phase III EVOKE-01 Study Open
PURPOSE The open-label, phase III EVOKE-01 study evaluated sacituzumab govitecan (SG) versus standard-of-care docetaxel in metastatic non–small cell lung cancer (mNSCLC) with progression on/after platinum-based chemotherapy, anti–PD-(L)1, …
View article: Oncological outcomes post transoral robotic surgery (TORS) for HPV-associated oropharyngeal squamous cell carcinoma, a single-centre retrospective Australian study
Oncological outcomes post transoral robotic surgery (TORS) for HPV-associated oropharyngeal squamous cell carcinoma, a single-centre retrospective Australian study Open
We present a cohort review of TORS resection for HPV-associated oropharyngeal squamous cell carcinoma (OPSCC) and its associated oncological outcomes spanning a 10-year period. A retrospective case series review was performed of patients u…
View article: Incidence and distribution of contralateral lymph node metastasis associated with human papillomavirus-related oropharyngeal squamous cell carcinoma
Incidence and distribution of contralateral lymph node metastasis associated with human papillomavirus-related oropharyngeal squamous cell carcinoma Open
Objective To analyse the rate of contralateral nodal metastasis in human papillomavirus (HPV)-associated oropharyngeal carcinoma and identify the patient cohorts that would benefit from bilateral neck treatment. Methods A retrospective coh…
View article: Protein Translation Dysregulation and Immune Cell Evasion Define Metastatic Clones in HPV-related Cancer of the Oropharynx
Protein Translation Dysregulation and Immune Cell Evasion Define Metastatic Clones in HPV-related Cancer of the Oropharynx Open
Summary Head and neck cancers, representing the seventh most common malignancy globally, have seen a shift in causative factors from traditional smoking and alcohol use to human papillomavirus (HPV) infection, now accounting for up to 80% …
View article: Carrying on with life as a lung cancer survivor: a qualitative study of Australian survivors’ employment, finances, relationships, and healthcare experiences
Carrying on with life as a lung cancer survivor: a qualitative study of Australian survivors’ employment, finances, relationships, and healthcare experiences Open
Many individuals living with LC want to "carry on" with life. Participants spoke of challenges and opportunities across life domains of relationships, work, and finances, and noted the importance of continued specialist healthcare througho…
View article: Development of clinically meaningful quality indicators for contemporary lung cancer care, and piloting and evaluation in a retrospective cohort; experiences of the Embedding Research (and Evidence) in Cancer Healthcare (EnRICH) Program
Development of clinically meaningful quality indicators for contemporary lung cancer care, and piloting and evaluation in a retrospective cohort; experiences of the Embedding Research (and Evidence) in Cancer Healthcare (EnRICH) Program Open
Objectives Lung cancer continues to be the most common cause of cancer-related death and the leading cause of morbidity and burden of disease across Australia. There is an ongoing need to identify and reduce unwarranted clinical variation …
View article: Oncological outcomes post transoral robotic surgery (TORS) for HPV-associated oropharyngeal squamous cell carcinoma, a single- center retrospective Australian study
Oncological outcomes post transoral robotic surgery (TORS) for HPV-associated oropharyngeal squamous cell carcinoma, a single- center retrospective Australian study Open
Background We present a cohort review of TORS resection for HPV-associated oropharyngeal squamous cell carcinoma (OPSCC) and its associated oncological outcomes spanning a 10-year period. Methods A retrospective case series review was perf…
View article: Clinicians’ Evaluation of Lung Cancer Clinical Quality Indicators and Comparative Performance Data in Practice
Clinicians’ Evaluation of Lung Cancer Clinical Quality Indicators and Comparative Performance Data in Practice Open
Objective. Lung cancer is commonly diagnosed and is the leading cause of cancer-related death, morbidity, and burden of disease globally. There is an ongoing need to ensure patients receive optimal evidence-based care and to identify and r…
View article: P2.10-01 ALKTERNATE: A Pilot Study Alternating Lorlatinib with Crizotinib in Patients with ALK+ NSCLC and ALK-inhibitor Resistance
P2.10-01 ALKTERNATE: A Pilot Study Alternating Lorlatinib with Crizotinib in Patients with ALK+ NSCLC and ALK-inhibitor Resistance Open
View article: 675 Safety and tolerability of magrolimab combination therapy in patients with recurrent or metastatic head and neck squamous cell carcinoma (RM-HNSCC)
675 Safety and tolerability of magrolimab combination therapy in patients with recurrent or metastatic head and neck squamous cell carcinoma (RM-HNSCC) Open
Background Novel combination therapies are needed to improve outcomes in RM-HNSCC. Magrolimab is a monoclonal antibody that blocks CD47, a 'don't eat me' signal overexpressed on cancer cells. Magrolimab induces macrophage-mediated phagocyt…
View article: Application of a revised model for coping with advanced cancer to qualitatively explore lung cancer survivors’ experiences of ongoing physical effects, novel treatments, uncertainty, and coping
Application of a revised model for coping with advanced cancer to qualitatively explore lung cancer survivors’ experiences of ongoing physical effects, novel treatments, uncertainty, and coping Open
View article: Two Very Rare Cases of Metastatic Thymic Carcinoma with Sjogren’s Syndrome: A Case Series
Two Very Rare Cases of Metastatic Thymic Carcinoma with Sjogren’s Syndrome: A Case Series Open
Thymic tumours are rare thoracic malignancies with thymic carcinoma accounting for approximately 12% of all thymic tumours compared to thymomas which account for approximately 86%. Unlike thymomas, it is very rare for thymic carcinomas to …
View article: Immune checkpoint inhibitors for advanced pancreatic cancer
Immune checkpoint inhibitors for advanced pancreatic cancer Open
This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To evaluate the benefits and harms of immune checkpoint inhibitors (ICIs), as monotherapy or in combination (with chemotherapy or targeted therapy), fo…
View article: Air pollution and lung cancer—A new era
Air pollution and lung cancer—A new era Open
The incidence of lung cancer—a 'Big 5' lung disease as highlighted by the Forum of International Respiratory Societies (FIRS)1—is increasing in never-smoking individuals, as worldwide smoking rates decline, and the Tobacco Endgame is comme…
View article: Supplementary Material for: Two very rare cases of metastatic thymic carcinoma with Sjogren’s syndrome: A Case series
Supplementary Material for: Two very rare cases of metastatic thymic carcinoma with Sjogren’s syndrome: A Case series Open
Thymic tumors are rare thoracic malignancies with thymic carcinoma accounting for approximately 12% of all thymic tumours compared to thymomas which account for approximately 86%. Unlike thymomas, it is very rare for thymic carcinomas to b…
View article: High cyclin <scp>E1</scp> protein, but not gene amplification, is prognostic for basal‐like breast cancer
High cyclin <span>E1</span> protein, but not gene amplification, is prognostic for basal‐like breast cancer Open
Basal‐like breast cancer (BLBC) has a greater overlap in molecular features with high‐grade serous ovarian cancer (HGSOC) than with other breast cancer subtypes. Similarities include BRCA1 mutation, high frequency of TP53 mutation, and amp…
View article: Resveratrol for Weight Loss in Obesity: An Assessment of Randomized Control Trial Designs in ClinicalTrials.gov
Resveratrol for Weight Loss in Obesity: An Assessment of Randomized Control Trial Designs in ClinicalTrials.gov Open
Resveratrol is a polyphenol that may improve weight loss outcomes in obese individuals. However, assessing the effectiveness of resveratrol supplementations as an appropriate intervention for weight loss in obesity across randomized contro…
View article: Activin-A, Growth Differentiation Factor-11 and Transforming Growth Factor-β as predictive biomarkers for platinum chemotherapy in advanced non-small cell lung cancer
Activin-A, Growth Differentiation Factor-11 and Transforming Growth Factor-β as predictive biomarkers for platinum chemotherapy in advanced non-small cell lung cancer Open
Within the confines of our study, Activin-A, GDF-11 and TGF-β expression was not a predictor of objective radiological response to chemotherapy or overall survival.
View article: A single-cell tumor immune atlas for precision oncology
A single-cell tumor immune atlas for precision oncology Open
The tumor immune microenvironment is a main contributor to cancer progression and a promising therapeutic target for oncology. However, immune microenvironments vary profoundly between patients, and biomarkers for prognosis and treatment r…
View article: National Presenters and Chairs
National Presenters and Chairs Open
In the clinic, she specializes in the treatment of cancers of the lung, head, and neck.In her research role, she works in the Garvan-Weizmann Centre for Cellular Genomics where she focuses on using cellular genomics techniques for biomarke…
View article: A non-genetic, cell cycle-dependent mechanism of platinum resistance in lung adenocarcinoma
A non-genetic, cell cycle-dependent mechanism of platinum resistance in lung adenocarcinoma Open
We previously used a pulse-based in vitro assay to unveil targetable signalling pathways associated with innate cisplatin resistance in lung adenocarcinoma (Hastings et al., 2020). Here, we advanced this model system and identified a non-g…