Venla Olsson
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View article: Redox Properties and in Vivo Magnetic Resonance Imaging of Cyclodextrin‐Polynitroxides Contrast Agents
Redox Properties and in Vivo Magnetic Resonance Imaging of Cyclodextrin‐Polynitroxides Contrast Agents Open
This paper reports the synthesis, characterization and in vivo application of water‐soluble supramolecular contrast agents (Mw: 5–5.6 kDa) for MRI obtained from β‐cyclodextrin functionalized with different kinds of nitroxide radicals, both…
View article: Lentivirus vector‑mediated genetic manipulation of oncogenic pathways induces tumor formation in rabbit brain
Lentivirus vector‑mediated genetic manipulation of oncogenic pathways induces tumor formation in rabbit brain Open
Translation of promising experimental therapies from rodent models to clinical success has been complicated as the novel therapies often fail in clinical trials. Existing rodent glioma models generally do not allow for preclinical evaluati…
View article: Detection of lentiviral suicide gene therapy in C6 rat glioma using hyperpolarised [1‐<sup>13</sup>C]pyruvate
Detection of lentiviral suicide gene therapy in C6 rat glioma using hyperpolarised [1‐<sup>13</sup>C]pyruvate Open
Hyperpolarised [1‐ 13 C]pyruvate MRI has shown promise in monitoring therapeutic efficacy in a number of cancers including glioma. In this study, we assessed the pyruvate response to the lentiviral suicide gene therapy of herpes simplex vi…
View article: Assessment of the Relaxation-Enhancing Properties of a Nitroxide-Based Contrast Agent TEEPO-Glc with <i>In Vivo</i> Magnetic Resonance Imaging
Assessment of the Relaxation-Enhancing Properties of a Nitroxide-Based Contrast Agent TEEPO-Glc with <i>In Vivo</i> Magnetic Resonance Imaging Open
Magnetic resonance imaging examinations are frequently carried out using contrast agents to improve the image quality. Practically all clinically used contrast agents are based on paramagnetic metals and lack in selectivity and specificity…
View article: Preclinical Proof-of-Concept, Analytical Development, and Commercial Scale Production of Lentiviral Vector in Adherent Cells
Preclinical Proof-of-Concept, Analytical Development, and Commercial Scale Production of Lentiviral Vector in Adherent Cells Open
The therapeutic efficacy of a lentiviral vector (LV) expressing the herpes simplex virus thymidine kinase (HSV-TK) was studied in an immunocompetent rat glioblastoma model. Intraperitoneal ganciclovir injections (50 mg/kg/day) were …
View article: Human Vascular Endothelial Growth Factor A165 Expression Induces the Mouse Model of Neovascular Age-Related Macular Degeneration
Human Vascular Endothelial Growth Factor A165 Expression Induces the Mouse Model of Neovascular Age-Related Macular Degeneration Open
Vascular endothelial growth factor (VEGF) expression induces age-related macular degeneration (AMD), which is a common vision-threatening disease due to choroidal neovascularization and a fibrovascular membrane. We describe a mouse model o…