Vera Dufner
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View article: P06.04.B Efficacy of Podoplanin-CAR-T Cells in<i>ex vivo</i> Patient Derived Glioblastoma Organoids
P06.04.B Efficacy of Podoplanin-CAR-T Cells in<i>ex vivo</i> Patient Derived Glioblastoma Organoids Open
Background Glioblastoma (GBM) is the most prevalent malignant brain tumor in adults. Recent immunotherapeutic approaches led to promising effects both in vitro and in preclinical animal models. However, tumor heterogeneity, antigen escape …
View article: P11.34.A Pseudoprogression in cases of brain metastases and its neurooncological pitfalls under PD-1 inhibitor therapy in the era of personalized medicine
P11.34.A Pseudoprogression in cases of brain metastases and its neurooncological pitfalls under PD-1 inhibitor therapy in the era of personalized medicine Open
Background Immunotherapy plays an increasing role in combating malignant cancers. Recently, there has been a noticeable uptick of pseudoprogression mimicking true tumor growth or even intracranial abscess. PD-1 inhibitors especially have c…
View article: War-related traumatic brain injuries during the Syrian armed conflict in Damascus 2014-2017: a cohort study and a literature review
War-related traumatic brain injuries during the Syrian armed conflict in Damascus 2014-2017: a cohort study and a literature review Open
Background: The decade-long Syrian armed conflict killed or injured more than 11% of the Syrian population. Head and neck injuries are the most frequent cause of war-related trauma, about half of which are brain injuries. Reports about Syr…
View article: The Emesis Trial: Depressive Glioma Patients Are More Affected by Chemotherapy-Induced Nausea and Vomiting
The Emesis Trial: Depressive Glioma Patients Are More Affected by Chemotherapy-Induced Nausea and Vomiting Open
Purpose Glioma patients face a limited life expectancy and at the same time, they suffer from afflicting symptoms and undesired effects of tumor treatment. Apart from bone marrow suppression, standard chemotherapy with temozolomide causes …
View article: P04.17 Antigen heterogeneity in glioblastoma cell lines, patient-derived cells, and patients’ glioblastoma tissue is an obstacle for CAR-T cell therapy development
P04.17 Antigen heterogeneity in glioblastoma cell lines, patient-derived cells, and patients’ glioblastoma tissue is an obstacle for CAR-T cell therapy development Open
BACKGROUND Immunotherapy targeting surface antigens, e.g. CAR-T-cell therapy has become a promising therapeutic approach for glioblastoma (GBM) treatment. Antigen heterogeneity constitutes a major obstacle not only for preclinical in vitro…
View article: The Emesis Trial: Depressive Patients with Brain Tumors are more Affected by Chemotherapy-induced Nausea and Vomiting
The Emesis Trial: Depressive Patients with Brain Tumors are more Affected by Chemotherapy-induced Nausea and Vomiting Open
Purpose: Patients with malignant brain tumors face a limited life expectancy and at the same time, they suffer from afflicting symptoms and undesired effects of tumor treatment. Apart from bone marrow suppression, standard chemotherapy wit…
View article: Optimization of radiation settings for angiography using 3D fluoroscopy for imaging of intracranial aneurysms
Optimization of radiation settings for angiography using 3D fluoroscopy for imaging of intracranial aneurysms Open
Mobile 3D fluoroscopes have become increasingly available in neurosurgical operating rooms. We recently reported its use for imaging cerebral vascular malformations and aneurysms. This study was conducted to evaluate various radiation sett…
View article: Long-term outcome of patients with relapsed/refractory B-cell non-Hodgkin lymphoma treated with blinatumomab
Long-term outcome of patients with relapsed/refractory B-cell non-Hodgkin lymphoma treated with blinatumomab Open
Blinatumomab, the first-in-class CD3/CD19 bispecific T-cell engager antibody construct, has recently been approved for treating patients with relapsed or refractory (R/R) B-cell acute lymphoblastic leukemia. However, the clinical proof of …
View article: P01.047 Improving quality of life in glioma patients: platform for exchange of patients’ expertise in TTFields practice
P01.047 Improving quality of life in glioma patients: platform for exchange of patients’ expertise in TTFields practice Open
Glioblastoma (GBM) atients nd their elatives (PaR) face tremendous distress and psychological burden due to limited survival and neurological/neuropsychological deficits. Tumor Treating Fields (TTFields, alternating electric fields at 200 …
View article: QLIF-32. MEETING THE PATIENTS - MEETING THE NEEDS: PLATFORMS FOR PATIENTS USING OPTUNE® TO EXCHANGE EXPERTISE
QLIF-32. MEETING THE PATIENTS - MEETING THE NEEDS: PLATFORMS FOR PATIENTS USING OPTUNE® TO EXCHANGE EXPERTISE Open
INTRODUCTION: Glioblastoma multiforme (GBM) patients and their relatives (PaR) face tremendous distress and psychological burden due to limited survival and neurological/neuropsychological deficits. Tumor Treating Fields (Optune®, TTFields…
View article: Applications of high‐resolution magic angle spinning MRS in biomedical studies II—Human diseases
Applications of high‐resolution magic angle spinning MRS in biomedical studies II—Human diseases Open
High‐resolution magic angle spinning (HRMAS) MRS is a powerful method for gaining insight into the physiological and pathological processes of cellular metabolism. Given its ability to obtain high‐resolution spectra of non‐liquid biologica…