Explanipedia

Improved MALDI-MS Imaging of Polar and <sup>2</sup>H-Labeled Metabolites in Mouse Organ Tissues Open

Siva Swapna Kasarla, Antonia Fecke, Karl W. Smith, Vera Flocke, Ulrich Flögel , et al. · 2025

Imaging small polar metabolites and analyzing their in vivo dynamics with stable isotope-labeled (SIL) tracing through various biochemical pathways, including the citric acid (TCA) cycle, glycolysis, and amino acid metabolism, have …

Improved MALDI-MS Imaging of Polar and 2H-1 Labeled Metabolites in Mouse Organ Tissues Open

Siva Swapna Kasarla, Antonia Fecke, Vera Flocke, Ulrich Flögel, Karl W. Smith , et al. · 2025

Imaging small polar metabolites and analyzing their in vivo dynamics with stable isotope labeled (SIL) tracing through various biochemical pathways, including citric acid (TCA) cycle, glycolysis, and amino acid metabolism, has gained subst…

Publisher Correction: Magnetic resonance reveals early lipid deposition in murine prediabetes as predictive marker for cardiovascular injury Open

K Héller, Vera Flocke, Tamara Straub, Zhaoping Ding, Tanu Srivastava , et al. · 2024

Magnetic resonance reveals early lipid deposition in murine prediabetes as predictive marker for cardiovascular injury Open

K Héller, Vera Flocke, Tamara Straub, Zhaoping Ding, Tanu Srivastava , et al. · 2024

People with diabetes have an increased cardiovascular risk and a poorer outcome after myocardial infarction (MI). However, the exact underlying mechanisms are still unclear, as is the question of which non-invasive measures could be used t…

In-vivo tracking of deuterium metabolism in mouse organs using LC-MS/MS Open

Siva Swapna Kasarla, Vera Flocke, Nay Min Min Thaw Saw, Antonia Fecke, Albert Sickmann , et al. · 2024

Mass spectrometry-based metabolomics with stable isotope labeling (SIL) is an established tool for sensitive and precise analyses of tissue metabolism, its flux, and pathway activities in diverse models of physiology and disease. Despite t…

Noninvasive assessment of metabolic turnover during inflammation by in vivo deuterium magnetic resonance spectroscopy Open

Vera Flocke, Sebastian Temme, Pascal Bouvain, Maria Grandoch, Ulrich Flögel · 2023

Background Inflammation and metabolism exhibit a complex interplay, where inflammation influences metabolic pathways, and in turn, metabolism shapes the quality of immune responses. Here, glucose turnover is of special interest, as proinfl…

Biodegradable polyphosphoester micelles act as both background-free 31P magnetic resonance imaging agents and drug nanocarriers Open

Olga Koshkina, Timo Rheinberger, Vera Flocke, Anton G. Windfelder, Pascal Bouvain , et al. · 2023

In vivo monitoring of polymers is crucial for drug delivery and tissue regeneration. Magnetic resonance imaging (MRI) is a whole-body imaging technique, and heteronuclear MRI allows quantitative imaging. However, MRI agents can result in e…

Non-invasive mapping of systemic neutrophil dynamics upon cardiovascular injury Open

Pascal Bouvain, Zhaoping Ding, Shiwa Kadir, Patricia Kleimann, Nils Kluge , et al. · 2023

Biodegradable Polyphosphoester Micelles Act as Both Background-free 31P Magnetic Resonance Imaging Agents and Drug Nanocarriers Open

Olga Koshkina, Timo Rheinberger, Vera Flocke, Anton G. Windfelder, Pascal Bouvain , et al. · 2022

Imaging and tracing materials inside the body is essential to develop functional materials for personalized therapies, including drug delivering nanocarriers and artificial tissues. Magnetic Resonance Imaging (MRI) is a key whole-body imag…

High-throughput screening of caterpillars as a platform to study host–microbe interactions and enteric immunity Open

Anton G. Windfelder, Frank Müller, Benedict Mc Larney, Michael Hentschel, Anna Christina Böhringer , et al. · 2022

Mammalian models of human disease are expensive and subject to ethical restrictions. Here, we present an independent platform for high-throughput screening, using larvae of the tobacco hornworm Manduca sexta , combining diagnostic imaging …

Multiparametric MRI identifies subtle adaptations for demarcation of disease transition in murine aortic valve stenosis Open

Christine Quast, Frank Kober, K Becker, Elric Zweck, Jasmina Hoffe , et al. · 2022

Dynamic monitoring of vital functions and tissue re-organization in Saturnia pavonia (Lepidoptera, Saturniidae) during final metamorphosis by non-invasive MRI Open

Tim Laußmann, Paul Urspruch, Vera Flocke, Anton G. Windfelder, Hermann Aberle , et al. · 2022

Magnetic resonance imaging (MRI) is the key whole-body imaging technology for observing processes within a living object providing excellent resolution and contrast between soft tissues. In the present work, we exploited the non-destructiv…

Multi-targeted 1H/19F MRI unmasks specific danger patterns for emerging cardiovascular disorders Open

Ulrich Flögel, Sebastian Temme, Christoph Jacoby, Thomas Oerther, Petra Keul , et al. · 2021

Ontological Expressivism Open

Vera Flocke · 2021

Ontological expressivism is the view that ontological existence claims express noncognitive mental states. The chapter develops a version of ontological expressivism that is modeled after Gibbard’s (2003) norm-expressivism. It argues that,…

Phagocytosis of a PFOB-Nanoemulsion for 19F Magnetic Resonance Imaging: First Results in Monocytes of Patients with Stable Coronary Artery Disease and ST-Elevation Myocardial Infarction Open

Fabian Nienhaus, Denise Colley, Annika Jahn, Susanne Pfeiler, Vera Flocke , et al. · 2019

Fluorine-19 magnetic resonance imaging (19F MRI) with intravenously applied perfluorooctyl bromide-nanoemulsions (PFOB-NE) has proven its feasibility to visualize inflammatory processes in experimental disease models. This approach is base…

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