Vera B. Kaiser
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LUMINIDEPENDENS orchestrates global transcriptional repression in <i>Arabidopsis</i> Open
Genomic integrity is constantly challenged by transcription/replication conflicts, a major source of replication stress and instability across all life forms. While extensive studies have elucidated mechanisms for resolving transcription/r…
CTCF-anchored chromatin loop dynamics during human meiosis Open
Background During meiosis, the mammalian genome is organised within chromatin loops, which facilitate synapsis, crossing over and chromosome segregation, setting the stage for recombination events and the generation of genetic diversity. C…
View article: Genetic background sets the trajectory of cancer evolution
Genetic background sets the trajectory of cancer evolution Open
Human cancers are heterogeneous. Their genomes evolve from genetically diverse germlines in complex and dynamic environments, including exposure to potential carcinogens. This heterogeneity of humans, our environmental exposures, and subse…
CTCF-anchored chromatin loop dynamics during human meiosis Open
Background During meiosis, the mammalian genome is organised within chromatin loops, which facilitate synapsis, crossing over and chromosome segregation, setting the stage for recombination events and the generation of genetic diversity. C…
Mutational bias in spermatogonia impacts the anatomy of regulatory sites in the human genome Open
Mutation in the germline is the ultimate source of genetic variation, but little is known about the influence of germline chromatin structure on mutational processes. Using ATAC-seq, we profile the open chromatin landscape of human spermat…
Mutational bias in spermatogonia impacts the anatomy of regulatory sites in the human genome Open
Mutation in the germline is the ultimate source of genetic variation, but little is known about the influence of germline chromatin structure on mutational processes. Using ATAC-seq, we profile the open chromatin landscape of human spermat…
Pervasive lesion segregation shapes cancer genome evolution Open
Summary Cancers arise through the acquisition of oncogenic mutations and grow through clonal expansion 1, 2 . Here we reveal that most mutagenic DNA lesions are not resolved as mutations within a single cell-cycle. Instead, DNA lesions seg…
Chromatin loop anchors are associated with genome instability in cancer and recombination hotspots in the germline Open
Chromatin loops form a basic unit of interphase nuclear organisation, providing contacts between regulatory regions and target promoters, and forming higher level patterns defining self interacting domains. Recent studies have shown that m…
When TADs go bad: chromatin structure and nuclear organisation in human disease Open
Chromatin in the interphase nucleus is organised as a hierarchical series of structural domains, including self-interacting domains called topologically associating domains (TADs). This arrangement is thought to bring enhancers into closer…
Genetic regulatory effects modified by immune activation contribute to autoimmune disease associations Open
The immune system plays a major role in human health and disease, and understanding genetic causes of interindividual variability of immune responses is vital. We isolated monocytes from 134 genotyped individuals, stimulated the cells with…
Mutational Biases Drive Elevated Rates of Substitution at Regulatory Sites across Cancer Types Open
Disruption of gene regulation is known to play major roles in carcinogenesis and tumour progression. Here, we comprehensively characterize the mutational profiles of diverse transcription factor binding sites (TFBSs) across 1,574 completel…