Vera Schmidt
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View article: Metformin mitigates aortic valve degeneration in an ex vivo three-dimensional tissue model
Metformin mitigates aortic valve degeneration in an ex vivo three-dimensional tissue model Open
Calcific aortic valve disease (CAVD) is a prevalent valvular disorder that lacks effective pharmacological treatments. Metformin, an oral anti-diabetic drug, has been suggested to protect valvular interstitial cells (VICs) from calcificati…
View article: Pioglitazone treatment mitigates cardiovascular bioprosthetic degeneration in a chronic kidney disease model
Pioglitazone treatment mitigates cardiovascular bioprosthetic degeneration in a chronic kidney disease model Open
Aims Chronic kidney disease (CKD) is a risk factor for the development of cardiovascular diseases, e.g., atherosclerosis and calcific aortic valve disease, leading inevitably to valve replacement surgery. CKD patients with bioprosthetic ca…
View article: Urban morphology as a key parameter for mitigating urban heat? – A literature review
Urban morphology as a key parameter for mitigating urban heat? – A literature review Open
More frequent and intense heat waves, especially in urban centers, represent a growing challenge for urban designers and building planners. In the last five years, extensive research has been undertaken on the relation between urban form, …
View article: Three-Dimensional Bioprinting of Ovine Aortic Valve Endothelial and Interstitial Cells for the Development of Multicellular Tissue Engineered Tissue Constructs
Three-Dimensional Bioprinting of Ovine Aortic Valve Endothelial and Interstitial Cells for the Development of Multicellular Tissue Engineered Tissue Constructs Open
To investigate the pathogenic mechanisms of calcified aortic valve disease (CAVD), it is necessary to develop a new three-dimensional model that contains valvular interstitial cells (VIC) and valvular endothelial cells (VEC). For this purp…
View article: 3D-bioprinting of aortic valve interstitial cells: impact of hydrogel and printing parameters on cell viability
3D-bioprinting of aortic valve interstitial cells: impact of hydrogel and printing parameters on cell viability Open
Calcific aortic valve disease (CAVD) is a frequent cardiac pathology in the aging society. Although valvular interstitial cells (VICs) seem to play a crucial role, mechanisms of CAVD are not fully understood. Development of tissue-engineer…
View article: Degeneration of biological heart valve grafts in a rat model of superoxide dismutase‐3 deficiency
Degeneration of biological heart valve grafts in a rat model of superoxide dismutase‐3 deficiency Open
While oxidative stress is known as key element in the pathogenesis of atherosclerosis and calcific aortic valve disease, its role in the degeneration of biological cardiovascular grafts has not been clarified yet. Therefore, the present st…
View article: Ventricular stabilization with a customized decellularized cardiac ECM-based scaffold after myocardial infarction alters gene expression in a rodent LAD-ligation model
Ventricular stabilization with a customized decellularized cardiac ECM-based scaffold after myocardial infarction alters gene expression in a rodent LAD-ligation model Open
Objectives: Decellularized extracellular matrix (dECM) is increasingly used in a wide range of regenerative medicine applications and may also offer the potential to support injured myocardium. Here, we evaluated the myocardial gene expres…
View article: Reproducible In Vitro Tissue Culture Model to Study Basic Mechanisms of Calcific Aortic Valve Disease: Comparative Analysis to Valvular Interstitials Cells
Reproducible In Vitro Tissue Culture Model to Study Basic Mechanisms of Calcific Aortic Valve Disease: Comparative Analysis to Valvular Interstitials Cells Open
The hallmarks of calcific aortic valve disease (CAVD), an active and regulated process involving the creation of calcium nodules, lipoprotein accumulation, and chronic inflammation, are the significant changes that occur in the composition…
View article: Influence of Laminin Coating on the Autologous In Vivo Recellularization of Decellularized Vascular Protheses
Influence of Laminin Coating on the Autologous In Vivo Recellularization of Decellularized Vascular Protheses Open
Decellularization of non-autologous biological implants reduces the immune response against foreign tissue. Striving for in vivo repopulation of aortic prostheses with autologous cells, thereby improving the graft biocompatibility, we exam…
View article: Rapid Fluorescence-based Characterization of Single Extracellular Vesicles in Human Blood with Nanoparticle-tracking Analysis
Rapid Fluorescence-based Characterization of Single Extracellular Vesicles in Human Blood with Nanoparticle-tracking Analysis Open
Extracellular vesicles (EVs), including exosomes, are specialized membranous nano-sized vesicles found in bodily fluids that are constitutively released from many cell types and play a pivotal role in regulating cell-cell communication and…
View article: Urban Breeding Grounds: Research and Design on Rochor+
Urban Breeding Grounds: Research and Design on Rochor+ Open
ISSN:2339-5427