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View article: A novel chemical entity, that reverses Warburg metabolism by disrupting VDAC1/HK2 interaction through “Toposteric Effect” in Cancer
A novel chemical entity, that reverses Warburg metabolism by disrupting VDAC1/HK2 interaction through “Toposteric Effect” in Cancer Open
Background Acidic pH and low oxygen levels Due to the Warburg effect have been shown to impart resistance to certain anti-cancer therapies for solid tumors, such as radiation and a variety of chemotherapeutic drugs. Cancer immunotherapy re…
View article: Boost Careers of Early-Stage Researchers
Boost Careers of Early-Stage Researchers Open
The white paper aims to inspire HR professionals at universities (of science and technology) to boost the careers of their early-stage researchers, to raise awareness amongst university leaders of the importance of this topic, and to showc…
View article: VDA-1102 : A Novel Well-Tolerated Treatment For Actinic Keratosis
VDA-1102 : A Novel Well-Tolerated Treatment For Actinic Keratosis Open
not available. Disclosures: Study sponsored by Vidac Pharma. Copyright 2018 SKIN
View article: A Hexokinase 2 Modulator for Field-Directed Treatment of Experimental Actinic Keratoses
A Hexokinase 2 Modulator for Field-Directed Treatment of Experimental Actinic Keratoses Open
Overexpression of hexokinase 2, and its binding to VDAC1 on the outer mitochondrial membrane of cancer cells, is key to their metabolic reprogramming to aerobic glycolysis, which enables them to proliferate. We describe Comp-1, an alloster…
View article: PO-424 modulating hexokinase 2 (HK2) as a novel approach to target metabolic immuno-oncology
PO-424 modulating hexokinase 2 (HK2) as a novel approach to target metabolic immuno-oncology Open
Introduction Metabolic reprogramming is one of the hallmarks of cancer, to support their needs for massive growth and proliferation. One major metabolic reprogramming is from oxidative phosphorylation to aerobic glycolysis, a well-documen…