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View article: The impact of shortening shifts of physicians during their residency on patients and physicians
The impact of shortening shifts of physicians during their residency on patients and physicians Open
Background Prolonged shifts in residency contribute to physician fatigue, cognitive decline, and increased medical errors. This systematic review and meta-analysis evaluate how reducing shift length affects patient-physician safety, physic…
View article: A time series analysis approach to quantify change in antibiotic resistance and antibiotic consumption during COVID-19 epidemics: a multicentre cross-national ecological study on behalf of QUantifying change in Antibiotic Resistance, ANTibiotic use, and INfection control during COVID-19 Epidemics study project
A time series analysis approach to quantify change in antibiotic resistance and antibiotic consumption during COVID-19 epidemics: a multicentre cross-national ecological study on behalf of QUantifying change in Antibiotic Resistance, ANTibiotic use, and INfection control during COVID-19 Epidemics study project Open
The COVID-19 pandemic was associated with higher usage of broad-spectrum antibiotics and higher incidence of multidrug-resistant bacteria, with great variability by countries. These results could support international action plans that emb…
View article: Pulmonary diffusing capacity among individuals recovering from mild to moderate COVID-19: a cross-sectional study
Pulmonary diffusing capacity among individuals recovering from mild to moderate COVID-19: a cross-sectional study Open
Impaired pulmonary diffusing capacity for carbon monoxide (DLCO) following COVID-19 has been consistently reported among individuals recovering from severe-critical infection. However, most long COVID cases follow non-severe COVID-19. We a…
View article: Quality, availability and suitability of antimicrobial stewardship guidance: a multinational qualitative study
Quality, availability and suitability of antimicrobial stewardship guidance: a multinational qualitative study Open
Background Antimicrobial stewardship (AMS) programmes are established across the world to treat infections efficiently, prioritize patient safety, and reduce the emergence of antimicrobial resistance. One of the core elements of AMS progra…
View article: Longer-term Mortality and Kidney Outcomes of Participants in the Combination Antibiotics for Methicillin-Resistant <i>Staphylococcus aureus</i> (CAMERA2) Trial: A Post Hoc Analysis
Longer-term Mortality and Kidney Outcomes of Participants in the Combination Antibiotics for Methicillin-Resistant <i>Staphylococcus aureus</i> (CAMERA2) Trial: A Post Hoc Analysis Open
Background The Combination Antibiotic Therapy for Methicillin-Resistant Staphylococcus aureus (CAMERA2) trial ceased recruitment in July 2018, noting that a higher proportion of patients in the intervention arm (combination therapy) develo…
View article: Prevalence and Clinical Consequences of Colistin Heteroresistance and Evolution into Full Resistance in Carbapenem-Resistant Acinetobacter baumannii
Prevalence and Clinical Consequences of Colistin Heteroresistance and Evolution into Full Resistance in Carbapenem-Resistant Acinetobacter baumannii Open
To our knowledge, this is the first large-scale study to report on HR in Gram-negative bacteria. We described the prevalence of colistin HR in a large sample of carbapenem-resistant A. baumannii isolates, the evolution of many colistin HR …
View article: Comment on Huang et al. Colistin Monotherapy versus Colistin plus Meropenem Combination Therapy for the Treatment of Multidrug-Resistant Acinetobacter baumannii Infection: A Meta-Analysis. J. Clin. Med. 2022, 11, 3239
Comment on Huang et al. Colistin Monotherapy versus Colistin plus Meropenem Combination Therapy for the Treatment of Multidrug-Resistant Acinetobacter baumannii Infection: A Meta-Analysis. J. Clin. Med. 2022, 11, 3239 Open
In the recently published meta-analysis titled “Colistin Monotherapy versus Colistin plus Meropenem Combination Therapy for the Treatment of Multidrug-Resistant Acinetobacter baumannii Infection: A Meta-Analysis”, Huang et al. compared the…
View article: Risk Factors and Multidimensional Assessment of Long Coronavirus Disease Fatigue: A Nested Case-Control Study
Risk Factors and Multidimensional Assessment of Long Coronavirus Disease Fatigue: A Nested Case-Control Study Open
Background Fatigue is the most prevalent and debilitating long-COVID (coronavirus disease) symptom; however, risk factors and pathophysiology of this condition remain unknown. We assessed risk factors for long-COVID fatigue and explored it…
View article: Excluded versus included patients in a randomized controlled trial of infections caused by carbapenem-resistant Gram-negative bacteria: relevance to external validity
Excluded versus included patients in a randomized controlled trial of infections caused by carbapenem-resistant Gram-negative bacteria: relevance to external validity Open
Background Population external validity is the extent to which an experimental study results can be generalized from a specific sample to a defined population. In order to apply the results of a study, we should be able to assess its popul…
View article: The Effectiveness and Safety of High-Dose Colistin: Prospective Cohort Study
The Effectiveness and Safety of High-Dose Colistin: Prospective Cohort Study Open
Background. Optimizing colistin dosing should translate to improved patient outcomes. Methods. We used data from 2 prospective cohort studies performed between 2006 and 2009 and between 2012 and 2015. In the latter period, a new policy of …
View article: Presentation of infection in older patients—a prospective study
Presentation of infection in older patients—a prospective study Open
Background. Traditional wisdom suggests that infections in older patients have atypical presentation, including blunted febrile response. Data are scarce. Design. We analyzed data from a prospectively collected database on presentation of …