Verena Moos
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View article: Risk Factors for Foodborne Zoonoses Among Populations With and Without a Migration Background in Berlin, Germany
Risk Factors for Foodborne Zoonoses Among Populations With and Without a Migration Background in Berlin, Germany Open
Knowledge gaps exist regarding foodborne zoonotic diseases in migrant populations. We assessed the seroprevalence of Campylobacter, Salmonella, Yersinia, Brucella, hepatitis E virus (HEV), and Trichinella, and identified potential exposure…
View article: Characterization of Biomarkers of Thrombo-Inflammation in Patients with First-Diagnosed Atrial Fibrillation
Characterization of Biomarkers of Thrombo-Inflammation in Patients with First-Diagnosed Atrial Fibrillation Open
Patients with first-diagnosed atrial fibrillation (FDAF) exhibit major adverse cardiovascular events (MACEs) during follow-up. Preclinical models have demonstrated that thrombo-inflammation mediates adverse cardiac remodeling and atherothr…
View article: A Colonic Organoid Model Challenged with the Large Toxins of Clostridioides difficile TcdA and TcdB Exhibit Deregulated Tight Junction Proteins
A Colonic Organoid Model Challenged with the Large Toxins of Clostridioides difficile TcdA and TcdB Exhibit Deregulated Tight Junction Proteins Open
Background: Clostridioides difficile toxins TcdA and TcdB are responsible for diarrhea and colitis. Lack of functional studies in organoid models of the gut prompted us to elucidate the toxin’s effects on epithelial barrier function and th…
View article: Uptake of Tropheryma whipplei by Intestinal Epithelia
Uptake of Tropheryma whipplei by Intestinal Epithelia Open
Background: Tropheryma whipplei (TW) can cause different pathologies, e.g., Whipple’s disease and transient gastroenteritis. The mechanism by which the bacteria pass the intestinal epithelial barrier, and the mechanism of TW-induced gastro…
View article: Intestinal Barrier in Post-Campylobacter jejuni Irritable Bowel Syndrome
Intestinal Barrier in Post-Campylobacter jejuni Irritable Bowel Syndrome Open
Background: Campylobacter jejuni (C. jejuni) is one of the most common causes of bacterial gastroenteritis worldwide. One sequela of this infection is the development of post-infectious irritable bowel syndrome (PI-IBS). It has been sugges…
View article: Cytotoxic CD8+ T Cells Are Involved in the Thrombo-Inflammatory Response during First-Diagnosed Atrial Fibrillation
Cytotoxic CD8+ T Cells Are Involved in the Thrombo-Inflammatory Response during First-Diagnosed Atrial Fibrillation Open
Background: Atrial myopathy and atrial fibrillation (AF) accompany thrombo-inflammation. This facilitates disease progression and promotes major adverse cardiovascular events (MACEs). Thrombin receptor (protease-activated receptor 1, PAR1)…
View article: Orbital manifestation of immune reconstitution inflammatory syndrome in Whipple’s Disease
Orbital manifestation of immune reconstitution inflammatory syndrome in Whipple’s Disease Open
View article: The spectrum of central nervous system involvement in Whipple's disease
The spectrum of central nervous system involvement in Whipple's disease Open
Background and purpose To assess the clinical spectrum of central nervous system (CNS) involvement as well as cerebrospinal fluid (CSF) and neuroimaging findings in patients with Whipple's disease (WD) and to analyze the association of neu…
View article: Intestinal barrier dysfunction mediates Whipple's disease immune reconstitution inflammatory syndrome (IRIS)
Intestinal barrier dysfunction mediates Whipple's disease immune reconstitution inflammatory syndrome (IRIS) Open
Background & Aims Classical Whipple's disease (CWD) affects the gastrointestinal tract and causes chronic diarrhea, malabsorption, and barrier dysfunction with microbial translocation (MT). Immune reconstitution inflammatory syndrome (IRIS…
View article: Pleiotropic Effects of the Protease-Activated Receptor 1 (PAR1) Inhibitor, Vorapaxar, on Atherosclerosis and Vascular Inflammation
Pleiotropic Effects of the Protease-Activated Receptor 1 (PAR1) Inhibitor, Vorapaxar, on Atherosclerosis and Vascular Inflammation Open
Background: Protease-activated receptor 1 (PAR1) and toll-like receptors (TLRs) are inflammatory mediators contributing to atherogenesis and atherothrombosis. Vorapaxar, which selectively antagonizes PAR1-signaling, is an approved, add-on …
View article: Untimely TGFβ responses in COVID-19 limit antiviral functions of NK cells
Untimely TGFβ responses in COVID-19 limit antiviral functions of NK cells Open
View article: Human small intestinal infection by SARS-CoV-2 is characterized by a mucosal infiltration with activated CD8+ T cells
Human small intestinal infection by SARS-CoV-2 is characterized by a mucosal infiltration with activated CD8+ T cells Open
The SARS-CoV-2 pandemic has so far claimed over three and a half million lives worldwide. Though the SARS-CoV-2 mediated disease COVID-19 has first been characterized by an infection of the upper airways and the lung, recent evidence sugge…
View article: Differential diagnostic value of rheumatic symptoms in patients with Whipple’s disease
Differential diagnostic value of rheumatic symptoms in patients with Whipple’s disease Open
View article: <i>Tropheryma whipplei</i> in Feces of Patients with Diarrhea in 3 Locations on Different Continents
<i>Tropheryma whipplei</i> in Feces of Patients with Diarrhea in 3 Locations on Different Continents Open
We examined fecal specimens of patients with diarrhea from 3 continents for Tropheryma whipplei and enteropathogens. T. whipplei was most common in South Africa, followed by Singapore and Germany. Its presence was associated with the prese…
View article: The colonic mucosa-associated microbiome in SIV infection: shift towards Bacteroidetes coincides with mucosal CD4+ T cell depletion and enterocyte damage
The colonic mucosa-associated microbiome in SIV infection: shift towards Bacteroidetes coincides with mucosal CD4+ T cell depletion and enterocyte damage Open
The intesinal microbiome is considered important in human immunodeficiency virus (HIV) pathogenesis and therefore represents a potential therapeutic target to improve the patients’ health status. Longitudinal alterations in the colonic muc…
View article: Curcumin Mitigates Immune-Induced Epithelial Barrier Dysfunction by Campylobacter jejuni
Curcumin Mitigates Immune-Induced Epithelial Barrier Dysfunction by Campylobacter jejuni Open
Campylobacter jejuni (C. jejuni) is the most common cause of foodborne gastroenteritis worldwide. The bacteria induce diarrhea and inflammation by invading the intestinal epithelium. Curcumin is a natural polyphenol from turmeric rhizome o…
View article: Whipple’s Disease: Diagnostic Value of rpoB Gene PCR from Peripheral Blood Mononuclear Cells
Whipple’s Disease: Diagnostic Value of rpoB Gene PCR from Peripheral Blood Mononuclear Cells Open
View article: Cell-Associated Simian Immunodeficiency Virus Accelerates Initial Virus Spread and CD4+ T-Cell Depletion in the Intestinal Mucosa
Cell-Associated Simian Immunodeficiency Virus Accelerates Initial Virus Spread and CD4+ T-Cell Depletion in the Intestinal Mucosa Open
Cell-free and cell-associated human immunodeficiency virus (HIV) may differently affect the immune system and the efficacy of prevention strategies. Here we examined mucosal events in simian immunodeficiency virus (SIV) infection, using in…
View article: Erratum: Campylobacter jejuni impairs sodium transport and epithelial barrier function via cytokine release in human colon
Erratum: Campylobacter jejuni impairs sodium transport and epithelial barrier function via cytokine release in human colon Open
View article: Campylobacter jejuni impairs sodium transport and epithelial barrier function via cytokine release in human colon
Campylobacter jejuni impairs sodium transport and epithelial barrier function via cytokine release in human colon Open
View article: Gastroenterologische Infektiologie
Gastroenterologische Infektiologie Open
XXXI 1 Einführung: Infektionskrankheiten in der Gastroenterologie -1 1.1 Literatur -4 2 Für den Gastroenterologen wichtige diagnostische Verfahren, Präanalytik -5 2.1 Bakteriologische Verfahren, Präanalytik-5 2.1.1Für den Gastroenterologen…
View article: Peripheral T-Cell Reactivity to Heat Shock Protein 70 and Its Cofactor GrpE from Tropheryma whipplei Is Reduced in Patients with Classical Whipple's Disease
Peripheral T-Cell Reactivity to Heat Shock Protein 70 and Its Cofactor GrpE from Tropheryma whipplei Is Reduced in Patients with Classical Whipple's Disease Open
Classical Whipple's disease (CWD) is characterized by the lack of specific Th1 response toward Tropheryma whipplei in genetically predisposed individuals. The cofactor GrpE of heat shock protein 70 (Hsp70) from T. whipplei was previously i…
View article: Architectural and functional alterations of the small intestinal mucosa in classical Whipple's disease
Architectural and functional alterations of the small intestinal mucosa in classical Whipple's disease Open
View article: More than meets the eye
More than meets the eye Open
A 74-year-old woman was admitted to the ophthalmology department with progressive vision loss, vitreous clouding and suspected endogenous endophthalmitis. Bilateral eye problems had started several weeks before and grew worse under oral pr…
View article: Usage of murine T-cell hybridoma cells as responder cells reveals interference of Helicobacter pylori with human dendritic cell-mediated antigen presentation
Usage of murine T-cell hybridoma cells as responder cells reveals interference of Helicobacter pylori with human dendritic cell-mediated antigen presentation Open
Direct effects of Helicobacter pylori ( H. pylori ) on human CD4 + T-cells hamper disentangling a possible bacterial-mediated interference with major histocompatibility complex class II (MHC-II)-dependent antigen presentation to these cell…
View article: Distribution and Activation of CD8+ T Cells in the Duodenal Mucosa before and after HIV Seroconversion
Distribution and Activation of CD8+ T Cells in the Duodenal Mucosa before and after HIV Seroconversion Open
CD8+ T cells in the intestinal mucosa influence the HIV-associated pathogenesis, but little is known about the dynamics of mucosal CD8+ T cell counts and activation of these cells during the course of infection. In this study, mucosal CD8+…
View article: Mucosal Inducible NO Synthase–Producing IgA+ Plasma Cells in <i>Helicobacter pylori</i>–Infected Patients
Mucosal Inducible NO Synthase–Producing IgA+ Plasma Cells in <i>Helicobacter pylori</i>–Infected Patients Open
The mucosal immune system is relevant for homeostasis, immunity, and also pathological conditions in the gastrointestinal tract. Inducible NO synthase (iNOS)–dependent production of NO is one of the factors linked to both antimicrobial imm…
View article: Refractory Celiac Disease New Diagnostic Approaches and Current Treatment
Refractory Celiac Disease New Diagnostic Approaches and Current Treatment Open
Since refractory celiac disease (RCD) may cause severe complications and is associated with a poor prognosis in a portion of patients, early diagnosis and treatment is of importance. Current diagnostics include complex PCR-based molecular …
View article: Specific CD4<sup>+</sup>T-Cell Reactivity and Cytokine Release in Different Clinical Presentations of Leptospirosis
Specific CD4<sup>+</sup>T-Cell Reactivity and Cytokine Release in Different Clinical Presentations of Leptospirosis Open
Clinical manifestations of leptospirosis are highly variable: from asymptomatic to severe and potentially fatal. The outcome of the disease is usually determined in the immunological phase, beginning in the second week of symptoms. The und…
View article: The effect of timing of antiretroviral therapy on CD4+ T-cell reconstitution in the intestine of HIV-infected patients
The effect of timing of antiretroviral therapy on CD4+ T-cell reconstitution in the intestine of HIV-infected patients Open