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View article: Antagonistic drug interactions protect commensal <i>Bacteroidaceae</i> from macrolides via an RND-type efflux pump
Antagonistic drug interactions protect commensal <i>Bacteroidaceae</i> from macrolides via an RND-type efflux pump Open
Antibiotics are essential to modern medicine, but their broad-spectrum activity can unintentionally disrupt the gut microbiota. This collateral damage may be alleviated by antagonistic drug interactions, in which specific compounds used in…
View article: Non-antibiotics disrupt colonization resistance against enteropathogens
Non-antibiotics disrupt colonization resistance against enteropathogens Open
Non-antibiotic drugs can alter the composition of the gut microbiome 1 , but they have largely unknown implications for human health 2 . Here we examined how non-antibiotics affect the ability of gut commensals to resist colonization by en…
View article: Fsr quorum sensing system restricts biofilm growth and activates inflammation in enterococcal infective endocarditis
Fsr quorum sensing system restricts biofilm growth and activates inflammation in enterococcal infective endocarditis Open
SUMMARY Infective endocarditis (IE) is a life-threatening biofilm-associated infection, yet the factors driving biofilm formation remain poorly understood. Here, we identified the Fsr quorum sensing (QS) system of Enterococcus faecalis as …