Verena Schultz
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View article: The potential of H5N1 viruses to adapt to bovine cells varies throughout evolution
The potential of H5N1 viruses to adapt to bovine cells varies throughout evolution Open
Avian influenza H5N1 clade 2.3.4.4b viruses caused a global panzootic and, unexpectedly, widespread outbreaks in dairy cattle, therefore representing a pandemic threat. To inform control strategies, it is critical to determine whether the …
View article: POLYGENIC DETERMINANTS OF H5N1 ADAPTATION TO BOVINE CELLS
POLYGENIC DETERMINANTS OF H5N1 ADAPTATION TO BOVINE CELLS Open
H5N1 avian influenza virus (lineage 2.3.4.4b, B3.13 genotype) has caused, unexpectedly, a large outbreak in dairy cattle in North America. It is critical to ascertain how this virus has specifically adapted to bovine cells and the molecula…
View article: BCAS1-positive oligodendrocytes enable efficient cortical remyelination in multiple sclerosis
BCAS1-positive oligodendrocytes enable efficient cortical remyelination in multiple sclerosis Open
Remyelination is a crucial regenerative process in demyelinating diseases, limiting persisting damage to the CNS. It restores saltatory nerve conduction and ensures trophic support of axons. In patients with multiple sclerosis, remyelinati…
View article: Influenza A and Respiratory Syncytial Virus Trigger a Cellular Response That Blocks Severe Acute Respiratory Syndrome Virus 2 Infection in the Respiratory Tract
Influenza A and Respiratory Syncytial Virus Trigger a Cellular Response That Blocks Severe Acute Respiratory Syndrome Virus 2 Infection in the Respiratory Tract Open
Background Multiple viruses cocirculate and contribute to the burden of respiratory disease. Virus-virus interactions can decrease susceptibility to infection and this interference can have an epidemiological impact. As humans are normally…
View article: SARM1 Depletion Slows Axon Degeneration in a CNS Model of Neurotropic Viral Infection
SARM1 Depletion Slows Axon Degeneration in a CNS Model of Neurotropic Viral Infection Open
Zika virus (ZIKV) is a neurotropic flavivirus recently linked to congenital ZIKV syndrome in children and encephalitis and Guillain-Barré syndrome in adults. Neurotropic viruses often use axons to traffic to neuronal or glial cell somas wh…
View article: Oligodendrocytes are susceptible to Zika virus infection in a mouse model of perinatal exposure: Implications for <scp>CNS</scp> complications
Oligodendrocytes are susceptible to Zika virus infection in a mouse model of perinatal exposure: Implications for <span>CNS</span> complications Open
Some children with proven intrauterine Zika virus (ZIKV) infection who were born asymptomatic subsequently manifested neurodevelopmental delays, pointing to impairment of development perinatally and postnatally. To model this, we infected …
View article: Modified recombinant human IgG1‐Fc is superior to natural intravenous immunoglobulin at inhibiting immune‐mediated demyelination
Modified recombinant human IgG1‐Fc is superior to natural intravenous immunoglobulin at inhibiting immune‐mediated demyelination Open
Intravenous immunoglobulin (IVIG) is an established treatment for numerous autoimmune conditions. Although Fc fragments derived from IVIG have shown efficacy in controlling immune thrombocytopenia in children, the mechanisms of action are …
View article: Zika Virus Infection Leads to Demyelination and Axonal Injury in Mature CNS Cultures
Zika Virus Infection Leads to Demyelination and Axonal Injury in Mature CNS Cultures Open
Understanding how Zika virus (Flaviviridae; ZIKV) affects neural cells is paramount in comprehending pathologies associated with infection. Whilst the effects of ZIKV in neural development are well documented, impact on the adult nervous s…
View article: Additional file 2 of Lipid-specific IgMs induce antiviral responses in the CNS: implications for progressive multifocal leukoencephalopathy in multiple sclerosis
Additional file 2 of Lipid-specific IgMs induce antiviral responses in the CNS: implications for progressive multifocal leukoencephalopathy in multiple sclerosis Open
Additional file 2: Table S1. Fifty most upregulated genes upregulated in DIV24 rat myelinating cultures treated 24 hrs with O4 compared to IgM control. Table S2. Significantly altered human disease pathways. Table S3. Significantly altered…
View article: Zika virus infection of glia leads to secondary injury to axons and dendrites
Zika virus infection of glia leads to secondary injury to axons and dendrites Open
Zika virus infection was recently linked to microcephaly and peripheral neuropathy (GBS) in Zika virus epidemic areas. Building on our previous work (Cumberworth et al , 2017) we investigated, in a time-course study, how the viral infectio…
View article: BCAS1 expression defines a population of early myelinating oligodendrocytes in multiple sclerosis lesions
BCAS1 expression defines a population of early myelinating oligodendrocytes in multiple sclerosis lesions Open
BCAS1 expression identifies newly formed and actively myelinating oligodendrocytes in development, adulthood, and disease.
View article: Zika virus tropism and interactions in myelinating neural cell cultures: CNS cells and myelin are preferentially affected
Zika virus tropism and interactions in myelinating neural cell cultures: CNS cells and myelin are preferentially affected Open
The recent global outbreak of Zika virus (ZIKV) infection has been linked to severe neurological disorders affecting the peripheral and central nervous systems (PNS and CNS, respectively). The pathobiology underlying these diverse clinical…
View article: Acutely damaged axons are remyelinated in multiple sclerosis and experimental models of demyelination
Acutely damaged axons are remyelinated in multiple sclerosis and experimental models of demyelination Open
Remyelination is in the center of new therapies for the treatment of multiple sclerosis to resolve and improve disease symptoms and protect axons from further damage. Although remyelination is considered beneficial in the long term, it is …
View article: Axonal degeneration and protection during early remyelination in multiple sclerosis and an animal model
Axonal degeneration and protection during early remyelination in multiple sclerosis and an animal model Open
Axonal damage, often followed by axonal degeneration, is the main cause of persisting disabilities in multiple sclerosis (MS) patients and already occurs in early stages of the disease. Disease progression is in addition characterized by d…