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View article: Urban environmental noise and depression causal pathway: Potential role of chronic conditions as mediator
Urban environmental noise and depression causal pathway: Potential role of chronic conditions as mediator Open
Background Accepting the fact of a growing urban population and associated health risks, such as increased exposure to pollutants, and considering the high prevalence of chronic diseases, this study aims to investigate the relationship bet…
View article: Effects of urban airborne particulate matter exposure on the human upper respiratory tract microbiome: a systematic review
Effects of urban airborne particulate matter exposure on the human upper respiratory tract microbiome: a systematic review Open
Exposure to air pollutants has a direct impact on human health, resulting in increased mortality rates. Airborne particulate matter (PM) has major adverse effects on health and can be classified as high-risk respiratory particles (fine/PM …
View article: Combination of toxicological and epidemiological approaches for estimating the health impact of atmospheric pollutants. A proof of concept for NO2
Combination of toxicological and epidemiological approaches for estimating the health impact of atmospheric pollutants. A proof of concept for NO2 Open
The proposed HIP conceptual approach offers promising advances for integrating experimental and epidemiological data. The next step is linking the concentration-adversity relationship with population health impacts through probability esti…
View article: Changes in the senescence profile and immune checkpoints in HIV-infected individuals after COVID-19
Changes in the senescence profile and immune checkpoints in HIV-infected individuals after COVID-19 Open
Background Both SARS-CoV-2 and HIV infection exhibit alterations in the senescence profile and immune checkpoint (IC) molecules. However, the midterm impact of SARS-CoV-2 on these profiles in people with HIV (PWH) remains unclear. This stu…
View article: Urban environmental noise and depression causal pathway: Potential role of chronic conditions as mediator
Urban environmental noise and depression causal pathway: Potential role of chronic conditions as mediator Open
Accepting the fact of a growing urban population and associated health risks, such as increased exposure to pollutants, and considering the high prevalence of chronic diseases, this study aims to investigate the relationship between exposu…
View article: Immunological and senescence biomarker profiles in patients after spontaneous clearance of hepatitis C virus: gender implications for long-term health risk
Immunological and senescence biomarker profiles in patients after spontaneous clearance of hepatitis C virus: gender implications for long-term health risk Open
Background About 25% of patients with acute hepatitis C virus (HCV) infection show spontaneous clearance within the first six months of infection but may remain at risk of inflammaging, aging, and liver and non-liver disease complications.…
View article: The mid-term impact of the SARS-CoV-2 infection on senescence profile and immune checkpoints in people living with HIV.
The mid-term impact of the SARS-CoV-2 infection on senescence profile and immune checkpoints in people living with HIV. Open
The mid-term impact of SARS-CoV-2 infection on senescence profile and immune checkpoints biomarkers in people living with HIV (PLWH) was assessed. Cross-sectional study in 95 PLWH on ART stratified by SARS-CoV-2 infection: a) 48 PLWH previ…
View article: HCV spontaneous clearers showed low senescence profile in people living with HIV under long ART
HCV spontaneous clearers showed low senescence profile in people living with HIV under long ART Open
Coinfection with hepatitis C virus (HCV) and human immunodeficiency virus (HIV) increases immune activation, inflammation, and oxidative stress that could lead to premature senescence. Different HCV infections, either acute or chronic infe…
View article: Dynamics of cellular senescence markers after HCV elimination spontaneously or by DAAs in people living with HIV
Dynamics of cellular senescence markers after HCV elimination spontaneously or by DAAs in people living with HIV Open
As the time since spontaneous resolution of HCV infection increased, patients had an improved senescence profile compared to the HIV group. Elimination of chronic HCV infection by DAAs led to a partial improvement of the senescent profile …
View article: P-8 EXTRACELLULAR VESICLE-DERIVED MICRORNA SIGNATURE IN HCV AND HCV/HIV PATIENTS WITH DIFFERENT STAGES OF LIVER FIBROSIS
P-8 EXTRACELLULAR VESICLE-DERIVED MICRORNA SIGNATURE IN HCV AND HCV/HIV PATIENTS WITH DIFFERENT STAGES OF LIVER FIBROSIS Open
Introduction and Objectives: Extracellular vesicles (EVs) are essential players in cell communication, and their cargo modulates the receptor cell response. MicroRNAs (miRNAs) proved to modulate the immune response both in physiological an…
View article: Dynamics of cellular senescence markers after HCV elimination in people living with HIV
Dynamics of cellular senescence markers after HCV elimination in people living with HIV Open
Background : Previously, we identified that different HCV infection, either acute or chronic infection in people living with HIV (PLWHIV) drives dissimilar cellular senescence profile. However, variations in these profiles after HCV cleara…
View article: HCV spontaneous clearers showed low senescence profile in people living with HIV
HCV spontaneous clearers showed low senescence profile in people living with HIV Open
Background : Co-infection with Hepatitis C virus (HCV) and Human Immunodeficiency Virus (HIV) increase immune activation, inflammation and oxidative stress that could lead to premature senescence. Different HCV infection, either acute or c…
View article: CORALIS, an R package for ncRNA-target enrichment analysis based on experimentally validated interactions
CORALIS, an R package for ncRNA-target enrichment analysis based on experimentally validated interactions Open
Non-coding RNAs are key regulatory molecules that govern a myriad of biological process by interacting and modulating the expression of their target protein-coding genes. The combination of RNA large-scale sequencing and computational anal…
View article: Phylogeography of hepatitis B virus: The role of Portugal in the early dissemination of HBV worldwide
Phylogeography of hepatitis B virus: The role of Portugal in the early dissemination of HBV worldwide Open
In Portugal, the genetic diversity, origin of HBV and the Portuguese role in the dissemination of HBV worldwide were never investigated. In this work, we studied the epidemic history and transmission dynamics of HBV genotypes that are ende…
View article: CORALIS, an R package for ncRNA-target enrichment analysis based on experimentally validated interactions
CORALIS, an R package for ncRNA-target enrichment analysis based on experimentally validated interactions Open
Non-coding RNAs are key regulatory molecules that govern a myriad of biological process by interacting and modulating the expression of their target protein-coding genes. The combination of RNA large-scale sequencing and computational anal…
View article: Dynamics of HIV Reservoir and HIV-1 Viral Splicing in HCV-Exposed Individuals after Elimination with DAAs or Spontaneous Clearance
Dynamics of HIV Reservoir and HIV-1 Viral Splicing in HCV-Exposed Individuals after Elimination with DAAs or Spontaneous Clearance Open
Background: Although human immunodeficiency virus type 1 (HIV-1) reservoir size is very stable under antiretroviral therapy (ART), individuals exposed to the Hepatitis C virus (HCV) (chronically coinfected and spontaneous clarifiers) show …
View article: T cell maturation and senescence after HCV cure in HIV-HCV coinfected patients: a prospective study
T cell maturation and senescence after HCV cure in HIV-HCV coinfected patients: a prospective study Open
Previously, we identified a stabilization of the HIV reservoir size in HIV + monoinfected and HIV+/HCV + coinfected patients who eliminated HCV with DAAs as well as a decrease in HIV reservoir size in HIV+/HCV- spontaneously clearers. Howe…
View article: Cross-Recognition of SARS-CoV-2 B-Cell Epitopes with Other Betacoronavirus Nucleoproteins
Cross-Recognition of SARS-CoV-2 B-Cell Epitopes with Other Betacoronavirus Nucleoproteins Open
The B and T lymphocytes of the adaptive immune system are important for the control of most viral infections, including COVID-19. Identification of epitopes recognized by these cells is fundamental for understanding how the immune system d…
View article: Phylogeography of hepatitis B: The role of Portugal in the early dissemination of HBV worldwide
Phylogeography of hepatitis B: The role of Portugal in the early dissemination of HBV worldwide Open
In 2015, 257 million people lived with chronic hepatitis B infection. In Portugal 1.4% of the population is chronically infected with hepatitis B virus. Limited information is available regarding the genetic diversity, origin of HBV in Por…