Veronica Craik
YOU?
Author Swipe
View article: Differential contribution of α2δ auxiliary subunits of voltage-gated calcium channels in mouse models of pain and itch
Differential contribution of α2δ auxiliary subunits of voltage-gated calcium channels in mouse models of pain and itch Open
Voltage-gated calcium channels (VGCCs) are multimeric proteins composed of alpha 1, β and γ subunits, as well as one of four auxiliary α2δ subunits. Although there is considerable preclinical and clinical evidence for a contribution of VGC…
View article: Virtual library docking for cannabinoid-1 receptor agonists with reduced side effects
Virtual library docking for cannabinoid-1 receptor agonists with reduced side effects Open
Virtual library docking can reveal unexpected chemotypes that complement the structures of biological targets. Seeking agonists for the cannabinoid-1 receptor (CB1R), we dock 74 million tangible molecules and prioritize 46 high ranking one…
View article: Structures of the σ2 receptor enable docking for bioactive ligand discovery
Structures of the σ2 receptor enable docking for bioactive ligand discovery Open
The σ2 receptor has attracted intense interest in cancer imaging1, psychiatric disease2, neuropathic pain3–5 and other areas of biology6,7. Here we determined the crystal structure of this receptor in complex with the clinical candidate ro…
View article: Structure-Based Design of a Chemical Probe Set for the 5-HT5A Serotonin Receptor
Structure-Based Design of a Chemical Probe Set for the 5-HT5A Serotonin Receptor Open
The 5-HT5A receptor (5-HT5AR), for which no selective agonists and a few antagonists exist, remains the least understood serotonin receptor. A single commercial antagonist, SB-699551, has been widely used to investigate the 5-HT5AR functio…
View article: Structure-based discovery of nonopioid analgesics acting through the α2A-adrenergic receptor
Structure-based discovery of nonopioid analgesics acting through the α2A-adrenergic receptor Open
Because nonopioid analgesics are much sought after, we computationally docked more than 301 million virtual molecules against a validated pain target, the α2A-adrenergic receptor (α2AAR), seeking new α2AAR agonists chemotypes that lack the…
View article: Docking for EP4R antagonists active against inflammatory pain
Docking for EP4R antagonists active against inflammatory pain Open
The lipid prostaglandin E 2 (PGE 2 ) mediates inflammatory pain by activating G protein-coupled receptors, including the prostaglandin E2 receptor 4 (EP4R). Nonsteroidal anti-inflammatory drugs (NSAIDs) reduce nociception by inhibiting pro…
View article: Large library docking for cannabinoid-1 receptor agonists with reduced side effects
Large library docking for cannabinoid-1 receptor agonists with reduced side effects Open
SUMMARY Large library docking can reveal unexpected chemotypes that complement the structures of biological targets. Seeking new agonists for the cannabinoid-1 receptor (CB1R), we docked 74 million tangible molecules, prioritizing 46 high …
View article: Structure-based discovery of nonopioid analgesics acting through the α <sub>2A</sub> -adrenergic receptor
Structure-based discovery of nonopioid analgesics acting through the α <sub>2A</sub> -adrenergic receptor Open
Because nonopioid analgesics are much sought after, we computationally docked more than 301 million virtual molecules against a validated pain target, the α 2A -adrenergic receptor (α 2A AR), seeking new α 2A AR agonists chemotypes that la…
View article: Structure-based Discovery of Conformationally Selective Inhibitors of the Serotonin Transporter
Structure-based Discovery of Conformationally Selective Inhibitors of the Serotonin Transporter Open
SUMMARY The serotonin transporter (SERT) removes synaptic serotonin and is the target of anti-depressant drugs. SERT adopts three conformations: outward-open, occluded, and inward-open. All known inhibitors target the outward-open state ex…
View article: Structure-Based Design of a Chemical Probe Set for the 5-HT <sub>5A</sub> Serotonin Receptor
Structure-Based Design of a Chemical Probe Set for the 5-HT <sub>5A</sub> Serotonin Receptor Open
The 5-HT5A receptor (5-HT5AR), for which no selective agonists and a few antagonists exist, remains the least understood serotonin receptor. A single commercial antagonist, SB-699551, has been widely used to investigate the 5-HT5AR functio…
View article: Structure-based design of a chemical probe set for the 5-HT<sub>5A</sub> serotonin receptor
Structure-based design of a chemical probe set for the 5-HT<sub>5A</sub> serotonin receptor Open
The 5-HT 5A receptor (5-HT 5A R), for which no selective agonists and only a few antagonists exist, remains the least understood serotonin (5-HT) receptor. A single commercial antagonist (SB-699551) has been widely used to investigate cent…
View article: Regulatory T-cells inhibit microglia-induced pain hypersensitivity in female mice
Regulatory T-cells inhibit microglia-induced pain hypersensitivity in female mice Open
Peripheral nerve injury-induced neuropathic pain is a chronic and debilitating condition characterized by mechanical hypersensitivity. We previously identified microglial activation via release of colony-stimulating factor 1 (CSF1) from in…
View article: Author response: Regulatory T-cells inhibit microglia-induced pain hypersensitivity in female mice
Author response: Regulatory T-cells inhibit microglia-induced pain hypersensitivity in female mice Open
Article Figures and data Abstract Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Peripheral nerve injury-induced neuropathi…
View article: Crystal structures of the σ<sub>2</sub>receptor template large-library docking for selective chemotypes active<i>in vivo</i>
Crystal structures of the σ<sub>2</sub>receptor template large-library docking for selective chemotypes active<i>in vivo</i> Open
The σ 2 receptor is a poorly understood transmembrane receptor that has attracted intense interest in many areas of biology including cancer imaging, Alzheimer’s disease, schizophrenia, and neuropathic pain. However, little is known regard…
View article: Hippocalcin-like 4, a neural calcium sensor, has a limited contribution to pain and itch processing
Hippocalcin-like 4, a neural calcium sensor, has a limited contribution to pain and itch processing Open
Calcium binding proteins are expressed throughout the central and peripheral nervous system and disruption of their activity has major consequences in a wide array of cellular processes, including transmission of nociceptive signals that a…
View article: Sensitivity of White and Opaque Candida albicans Cells to Antifungal Drugs
Sensitivity of White and Opaque Candida albicans Cells to Antifungal Drugs Open
White and opaque cells of Candida albicans have the same genome but differ in gene expression patterns, metabolic profiles, and host niche preferences. We tested whether these differences, which include the differential expression of drug …
View article: Systematic Genetic Screen for Transcriptional Regulators of the <i>Candida albicans</i> White-Opaque Switch
Systematic Genetic Screen for Transcriptional Regulators of the <i>Candida albicans</i> White-Opaque Switch Open
The human fungal pathogen Candida albicans can reversibly switch between two cell types named “white” and “opaque,” each of which is stable through many cell divisions. These two cell types differ in their ability to mate, their metabolic …