Veronica D. Gonzalez
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View article: Somatic mtDNA mutations at intermediate levels of heteroplasmy are a source of functional heterogeneity among primary leukemic cells
Somatic mtDNA mutations at intermediate levels of heteroplasmy are a source of functional heterogeneity among primary leukemic cells Open
Somatic mitochondrial DNA (mtDNA) mutations are frequently observed in tumors, yet their role in pediatric cancers remains poorly understood. The heteroplasmic nature of mtDNA—where mutant and wild-type mtDNA coexist—complicates efforts to…
View article: Coordinated protein modules define DNA damage responses to carboplatin at single-cell resolution in human ovarian carcinoma models
Coordinated protein modules define DNA damage responses to carboplatin at single-cell resolution in human ovarian carcinoma models Open
View article: Coordinated protein modules define DNA damage responses to carboplatin at single cell resolution in human ovarian carcinoma models
Coordinated protein modules define DNA damage responses to carboplatin at single cell resolution in human ovarian carcinoma models Open
Tubo-ovarian high-grade serous carcinoma (HGSC) is the most lethal gynecological malignancy and frequently responds to platinum-based chemotherapy because of common genetic and somatic impairment of DNA damage repair (DDR) pathways. The me…
View article: Use of spent brewer’s yeasts as an additive of pasture silages and its effects on nutritional quality and pH
Use of spent brewer’s yeasts as an additive of pasture silages and its effects on nutritional quality and pH Open
Livestock systems at Region Aysén del General Carlos Ibáñez del Campo depend on forage conservation during the spring-summer season, generally with low nutritional quality to animal requirements. To reduce nutrient loss, additives are comm…
View article: Coordinated Protein Modules Define DNA Damage Responses to Carboplatin at Single Cell Resolution in Human Ovarian Carcinoma Models
Coordinated Protein Modules Define DNA Damage Responses to Carboplatin at Single Cell Resolution in Human Ovarian Carcinoma Models Open
View article: Nano-in-nano enteric protein delivery system: coaxial Eudragit® L100-55 fibers containing poly(<i>N</i>-vinylcaprolactam) nanogels
Nano-in-nano enteric protein delivery system: coaxial Eudragit® L100-55 fibers containing poly(<i>N</i>-vinylcaprolactam) nanogels Open
Novel nano-in-nano coaxial platform for enteric protein delivery.
View article: «Preferiría pintarme los labios»: notas sobre la resistencia (irrepresentable) en Foucault y Derrida
«Preferiría pintarme los labios»: notas sobre la resistencia (irrepresentable) en Foucault y Derrida Open
El siguiente artículo examina la noción de resistencia elaborando un análisis que problematiza el lugar de la representación en política y en democracia. En un primer momento, se plantea el problema a partir de un relato que narra un episo…
View article: Multiparameter single-cell proteomic technologies give new insights into the biology of ovarian tumors
Multiparameter single-cell proteomic technologies give new insights into the biology of ovarian tumors Open
View article: Elevated CD47 is a hallmark of dysfunctional aged muscle stem cells that can be targeted to augment regeneration
Elevated CD47 is a hallmark of dysfunctional aged muscle stem cells that can be targeted to augment regeneration Open
View article: Hybrid Fluorescent Mass-Tag Nanotrackers as Universal Reagents for Long-Term Live-Cell Barcoding
Hybrid Fluorescent Mass-Tag Nanotrackers as Universal Reagents for Long-Term Live-Cell Barcoding Open
Barcoding and pooling cells for processing as a composite sample are critical to minimize technical variability in multiplex technologies. Fluorescent cell barcoding has been established as a standard method for multiplexing in flow cytome…
View article: Measuring trogocytosis between ovarian tumor and natural killer cells
Measuring trogocytosis between ovarian tumor and natural killer cells Open
Trogocytosis is an active transport mechanism by which one cell extracts a plasma membrane fragment with embedded molecules from an adjacent cell in a contact-dependent process leading to the acquisition of a new function. Our protocol, wh…
View article: Elevated CD47 is a hallmark of dysfunctional aged muscle stem cells that can be targeted to augment regeneration
Elevated CD47 is a hallmark of dysfunctional aged muscle stem cells that can be targeted to augment regeneration Open
SUMMARY In aging, skeletal muscle strength and regenerative capacity declines due, in part, to functional impairment of muscle stem cells (MuSCs), yet the underlying mechanisms remain elusive. Here we capitalize on mass-cytometry to identi…
View article: Mass Cytometry for the Characterization of Individual Cell Types in Ovarian Solid Tumors
Mass Cytometry for the Characterization of Individual Cell Types in Ovarian Solid Tumors Open
View article: Cell-targeted PD-1 agonists that mimic PD-L1 are potent T cell inhibitors
Cell-targeted PD-1 agonists that mimic PD-L1 are potent T cell inhibitors Open
The PD-1/PD-L1 pathway is a key immune checkpoint that regulates T cell activation. There is strong rationale to develop PD-1 agonists as therapeutics against autoimmunity, but progress in this area has been limited. Here, we generated T c…
View article: High-grade serous ovarian tumor cells modulate NK cell function to create an immune-tolerant microenvironment
High-grade serous ovarian tumor cells modulate NK cell function to create an immune-tolerant microenvironment Open
View article: Multilobular morphology: the key for biphase multifunctional nanogels
Multilobular morphology: the key for biphase multifunctional nanogels Open
This article provides, for the first time, the synthesis of two-phase nanogels with multilobular morphology under experimental and theoretical approaches, and underlines their potential as a candidate for controlled delivery platforms.
View article: Accurate Genomic Variant Detection in Single Cells with Primary Template-Directed Amplification
Accurate Genomic Variant Detection in Single Cells with Primary Template-Directed Amplification Open
Improvements in whole genome amplification (WGA) would enable new types of basic and applied biomedical research, including studies of intratissue genetic diversity that require more accurate single-cell genotyping. Here we present primary…
View article: Latex particles by emulsion and dispersion polymerizations: sensitization with specific antigens of leptospirosis and application to immunoagglutination
Latex particles by emulsion and dispersion polymerizations: sensitization with specific antigens of leptospirosis and application to immunoagglutination Open
View article: Terminal Effector CD8 T Cells Defined by an IKZF2+IL-7R− Transcriptional Signature Express FcγRIIIA, Expand in HIV Infection, and Mediate Potent HIV-Specific Antibody-Dependent Cellular Cytotoxicity
Terminal Effector CD8 T Cells Defined by an IKZF2+IL-7R− Transcriptional Signature Express FcγRIIIA, Expand in HIV Infection, and Mediate Potent HIV-Specific Antibody-Dependent Cellular Cytotoxicity Open
HIV-1 infection expands large populations of late-stage differentiated CD8 T cells that may persist long after viral escape from TCR recognition. In this study, we investigated whether such CD8 T cell populations can perform unconventional…
View article: N,N-DIMETHYLACRYLAMIDE HYDROGELS FOR CONTROLLED DRUG DELIVERY. INFLUENCE OF NETWORK STRUCTURE AND DRUG SOLUBILITY ON THE LOAD AND RELEASE MECHANISMS
N,N-DIMETHYLACRYLAMIDE HYDROGELS FOR CONTROLLED DRUG DELIVERY. INFLUENCE OF NETWORK STRUCTURE AND DRUG SOLUBILITY ON THE LOAD AND RELEASE MECHANISMS Open
The aim of the present work was to synthesize sustained-release hydrogels based on N,N-dimethylacrylamide (DMA) to study the effect of the polymer matrix structure and the solubility of drugs on the load and release mechanisms. A series of…
View article: Identification of NK Cell Subpopulations That Differentiate HIV-Infected Subject Cohorts with Diverse Levels of Virus Control
Identification of NK Cell Subpopulations That Differentiate HIV-Infected Subject Cohorts with Diverse Levels of Virus Control Open
HIV infection results in the establishment of a stable reservoir of latently infected cells; ART is usually required to keep viral replication under control and disease progression at bay, though a small subset of HIV-infected subjects can…
View article: High incidence of MDR and XDR Pseudomonas aeruginosa isolates obtained from patients with ventilator-associated pneumonia in Greece, Italy and Spain as part of the MagicBullet clinical trial
High incidence of MDR and XDR Pseudomonas aeruginosa isolates obtained from patients with ventilator-associated pneumonia in Greece, Italy and Spain as part of the MagicBullet clinical trial Open
Objectives To characterize the antimicrobial susceptibility, molecular epidemiology and carbapenem resistance mechanisms in Pseudomonas aeruginosa isolates recovered from respiratory tract samples from patients with ventilator-associated p…
View article: Diseño y puesta a punto de pruebas "Point-of-Care Testing" para el diagnóstico de zoonosis locales basadas en partículas de látex
Diseño y puesta a punto de pruebas "Point-of-Care Testing" para el diagnóstico de zoonosis locales basadas en partículas de látex Open
El uso de pruebas de diagnóstico en el punto de atención (Point-of-Care - POC) se define como la práctica de realizar ensayos a partir de especímenes clínicos al lado de o cerca del paciente, bajo la premisa que los resultados de las prueb…
View article: Effect of Delivery Platforms Structure on the Epidermal Antigen Transport for Topical Vaccination
Effect of Delivery Platforms Structure on the Epidermal Antigen Transport for Topical Vaccination Open
Transdermal immunization is highly attractive because of the skin's accessibility and unique immunological characteristics. However, it remains a relatively unexplored route of administration because of the great difficulty of transporting…
View article: An improved approach to estimate the avidity index of immunoglobulins: Evaluation of the method using IgG anti- Toxoplasma gondii
An improved approach to estimate the avidity index of immunoglobulins: Evaluation of the method using IgG anti- Toxoplasma gondii Open
Fil: Garcia, Valeria Soledad. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Conicet - Santa Fe. Instituto de Desarrollo Tecnologico para la Industria Quimica. Universidad Nacional del Litoral. In…
View article: Thermoresponsive nanogels with film-forming ability
Thermoresponsive nanogels with film-forming ability Open
A one pot semibatch method was proposed for synthesizing poly(N-vinylcaprolactam)-based nanogels with particle coalescence ability.
View article: Atomic mass tag of bismuth‐209 for increasing the immunoassay multiplexing capacity of mass cytometry
Atomic mass tag of bismuth‐209 for increasing the immunoassay multiplexing capacity of mass cytometry Open
Mass cytometry (or CyTOF) is an atomic mass spectrometry‐based single‐cell immunoassay technology, which has provided an increasingly systematic and sophisticated view in basic biological and clinical studies. Using elemental reporters com…
View article: Effects of the liposomal co-encapsulation of antigen and PO-CpG oligonucleotide on immune response in mice
Effects of the liposomal co-encapsulation of antigen and PO-CpG oligonucleotide on immune response in mice Open
The development of novel vaccines requires the design of new adjuvants able to give long lasting immune responses. Our aim was to obtain cationic liposomes as adjuvants by an industry-suitable method, and evaluate them using bovine serum a…
View article: Diagnosis of toxoplasmosis in pregnancy. Evaluation of latex–protein complexes by immnunoagglutination
Diagnosis of toxoplasmosis in pregnancy. Evaluation of latex–protein complexes by immnunoagglutination Open
SUMMARY The aim of this work was to obtain a reagent based on latex particles for ruling out acute toxoplasmosis in pregnant women by immunoagglutination (IA). Latex–protein complexes (LPC) were previously synthesized coupling the recombin…
View article: High‐throughput precision measurement of subcellular localization in single cells
High‐throughput precision measurement of subcellular localization in single cells Open
To quantify visual and spatial information in single cells with a throughput of thousands of cells per second, we developed Subcellular Localization Assay (SLA). This adaptation of Proximity Ligation Assay expands the capabilities of flow …