Explanipedia

Physical exercise modulates plasma irisin levels in endurance athletes: Implications for Parkinson's disease Open

Piergiorgio Grillo, D. Di Martino, Alessandra Calculli, Roberto De Icco, Luca Martinis , et al. · 2025

Physical exercise (PE) improves clinical outcomes in individuals with Parkinson's disease (PD) through unclear mechanisms. Irisin, a neuroprotective protein released by myocytes during PE, may play a role, but in vivo data in PD are limite…

Synaptic Interactions Between Serotonergic and Dopaminergic Systems in Parkinson’s Disease Open

Gioia Marino, Federica Campanelli, Giuseppina Natale, Maria De Carluccio, Federica Servillo , et al. · 2025

Since both serotonergic and dopaminergic afferents densely innervate many parts of the central nervous system, intact crosstalk between serotonin (5-HT) and dopamine (DA) transmission is essential for regulating synaptic plasticity in the …

Molecular and cellular determinants of L-Dopa-induced dyskinesia in Parkinson’s Disease Open

Federica Servillo, Maria De Carluccio, Giulia Di Lazzaro, Federica Campanelli, Gioia Marino , et al. · 2024

Editorial: Women in cellular neuropathology Open

Veronica Ghiglieri, Maria Teresa Viscomi · 2024

EDITORIAL article Front. Cell. Neurosci., 09 May 2024Sec. Cellular Neuropathology Volume 18 - 2024 | https://doi.org/10.3389/fncel.2024.1423482

Astrocyte Responses Influence Local Effects of Whole‐Brain Magnetic Stimulation in Parkinsonian Rats Open

Giuseppina Natale, Micol Colella, Maria De Carluccio, Daniele Lelli, Alessandra Paffi , et al. · 2023

Background Excessive glutamatergic transmission in the striatum is implicated in Parkinson's disease (PD) progression. Astrocytes maintain glutamate homeostasis, protecting from excitotoxicity through the glutamate–aspartate transporter (G…

Intensive exercise ameliorates motor and cognitive symptoms in experimental Parkinson’s disease restoring striatal synaptic plasticity Open

Gioia Marino, Federica Campanelli, Giuseppina Natale, Maria De Carluccio, Federica Servillo , et al. · 2023

Intensive physical activity improves motor functions in patients with Parkinson’s disease (PD) at early stages. However, the mechanisms underlying the beneficial effects of exercise on PD-associated neuronal alterations have not been fully…

Advances in understanding the function of alpha-synuclein: implications for Parkinson’s disease Open

Paolo Calabresi, Giulia Di Lazzaro, Gioia Marino, Federica Campanelli, Veronica Ghiglieri · 2023

The critical role of alpha-synuclein in Parkinson’s disease represents a pivotal discovery. Some progress has been made over recent years in identifying disease-modifying therapies for Parkinson’s disease that target alpha-synuclein. Howev…

Sarcopenia and Cognitive Decline in Older Adults: Targeting the Muscle–Brain Axis Open

Beatrice Arosio, Riccardo Calvani, Evelyn Ferri, Hélio José Coelho‐Júnior, Angelica Carandina , et al. · 2023

Declines in physical performance and cognition are commonly observed in older adults. The geroscience paradigm posits that a set of processes and pathways shared among age-associated conditions may also serve as a molecular explanation for…

Alpha-synuclein in Parkinson’s disease and other synucleinopathies: from overt neurodegeneration back to early synaptic dysfunction Open

Paolo Calabresi, Alessandro Mechelli, Giuseppina Natale, Laura A. Volpicelli‐Daley, Giulia Di Lazzaro , et al. · 2023

Although the discovery of the critical role of α-synuclein (α-syn) in the pathogenesis of Parkinson’s disease (PD) is now twenty-five years old, it still represents a milestone in PD research. Abnormal forms of α-syn trigger selective and …

Striatal glutamatergic hyperactivity in Parkinson's disease Open

Federica Campanelli, Giuseppina Natale, Gioia Marino, Veronica Ghiglieri, Paolo Calabresi · 2022

Effects of uremic toxins on hippocampal synaptic transmission: implication for neurodegeneration in chronic kidney disease Open

Giuseppina Natale, Valeria Calabrese, Gioia Marino, Federica Campanelli, Federica Urciuolo , et al. · 2021

CalDAG-GEFI mediates striatal cholinergic modulation of dendritic excitability, synaptic plasticity and psychomotor behaviors Open

Jill R. Crittenden, Shenyu Zhai, Magdalena Sauvage, Takashi Kitsukawa, Eric Burguière , et al. · 2021

CalDAG-GEFI mediates striatal cholinergic modulation of dendritic excitability, synaptic plasticity and psychomotor behaviors Open

Jill R. Crittenden, Shenyu Zhai, Magdalena Sauvage, Takashi Kitsukawa, Eric Burguière , et al. · 2021

CalDAG-GEFI (CDGI) is a protein highly enriched in the striatum, particularly in the principal spiny projection neurons (SPNs). CDGI is strongly down-regulated in two hyperkinetic conditions related to striatal dysfunction: Huntington’s di…

Transcranial Magnetic Stimulation Exerts “Rejuvenation” Effects on Corticostriatal Synapses after Partial Dopamine Depletion Open

Giuseppina Natale, Annabella Pignataro, Gioia Marino, Federica Campanelli, Valeria Calabrese , et al. · 2021

Background In experimental models of Parkinson's disease (PD), different degrees of degeneration to the nigrostriatal pathway produce distinct profiles of synaptic alterations that depend on progressive changes in N‐methyl‐D‐aspartate rece…

Dopamine-dependent early synaptic and motor dysfunctions induced by α-synuclein in the nigrostriatal circuit Open

Alessandro Tozzi, Miriam Sciaccaluga, Vittorio Loffredo, Alfredo Megaro, Ada Ledonne , et al. · 2021

Misfolding and aggregation of α-synuclein are specific features of Parkinson’s disease and other neurodegenerative diseases defined as synucleinopathies. Parkinson’s disease progression has been correlated with the formation and extracellu…

Serotonin drives striatal synaptic plasticity in a sex-related manner Open

Federica Campanelli, Gioia Marino, Noemi Barsotti, Giuseppina Natale, Valeria Calabrese , et al. · 2021

Neuro-Immune Cross-Talk in the Striatum: From Basal Ganglia Physiology to Circuit Dysfunction Open

Andrea Mancini, Veronica Ghiglieri, Lucilla Parnetti, Paolo Calabresi, Massimiliano Di Filippo · 2021

The basal ganglia network is represented by an interconnected group of subcortical nuclei traditionally thought to play a crucial role in motor learning and movement execution. During the last decades, knowledge about basal ganglia physiol…

Long-Term Shaping of Corticostriatal Synaptic Activity by Acute Fasting Open

Federica Campanelli, Daniela Laricchiuta, Giuseppina Natale, Gioia Marino, Valeria Calabrese , et al. · 2021

Food restriction is a robust nongenic, nonsurgical and nonpharmacologic intervention known to improve health and extend lifespan in various species. Food is considered the most essential and frequently consumed natural reward, and current …

Maternal stress programs accelerated aging of the basal ganglia motor system in offspring Open

Jordan Marrocco, Rémy Verhaeghe, Domenico Bucci, Luisa Di Menna, Anna Traficante , et al. · 2020

Rapamycin, by Inhibiting mTORC1 Signaling, Prevents the Loss of Striatal Bidirectional Synaptic Plasticity in a Rat Model of L-DOPA-Induced Dyskinesia Open

Valeria Calabrese, Anna Maio, Gioia Marino, Antonella Cardinale, Giuseppina Natale , et al. · 2020

Levodopa (L-DOPA) treatment is the main gold-standard therapy for Parkinson disease (PD). Besides good antiparkinsonian effects, prolonged use of this drug is associated to the development of involuntary movements known as L-DOPA-induced d…

Author Correction: Blunting neuroinflammation with resolvin D1 prevents early pathology in a rat model of Parkinson’s disease Open

Paraskevi Krashia, Alberto Cordella, Annalisa Nobili, Livia La Barbera, Mauro Federici , et al. · 2019

Blunting neuroinflammation with resolvin D1 prevents early pathology in a rat model of Parkinson's disease Open

Paraskevi Krashia, Alberto Cordella, Annalisa Nobil, Livia La Barbera, Mauro Federici , et al. · 2019

Neuroinflammation is one of the hallmarks of Parkinson's disease (PD) and may contribute to midbrain dopamine (DA) neuron degeneration. Recent studies link chronic inflammation with failure to resolve early inflammation, a process operated…

Blunting neuroinflammation with resolvin D1 prevents early pathology in a rat model of Parkinson’s disease Open

Paraskevi Krashia, Alberto Cordella, Annalisa Nobili, Livia La Barbera, Mauro Federici , et al. · 2019

Neuroinflammation is one of the hallmarks of Parkinson’s disease (PD) and may contribute to midbrain dopamine (DA) neuron degeneration. Recent studies link chronic inflammation with failure to resolve early inflammation, a process operated…

Mutations in CalDAG-GEFI Lead to Striatal Signaling Deficits and Psychomotor Symptoms in Multiple Species Including Human Open

Jill R. Crittenden, Magdalena Sauvage, Takashi Kitsukawa, Eric Burguière, Carlos Cepeda , et al. · 2019

SUMMARY Syndromes caused by mutations in Ras-MAP kinase signaling molecules are known as RASopathies and share features such as developmental delay, autistic traits, and cancer. Syndromic features of Rap-MAP kinase signaling defects remain…

Alpha-synuclein targets GluN2A NMDA receptor subunit causing striatal synaptic dysfunction and visuospatial memory alteration Open

Valentina Durante, Antonio de Iure, Vittorio Loffredo, Nishant N. Vaikath, Maria De Risi , et al. · 2019

Parkinson's disease is a progressive neurodegenerative disorder characterized by altered striatal dopaminergic signalling that leads to motor and cognitive deficits. Parkinson's disease is also characterized by abnormal presence of soluble…

Striatal spreading depolarization: Possible implication in levodopa‐induced dyskinetic‐like behavior Open

Antonio de Iure, Francesco Napolitano, Goichi Beck, Ana Quiroga‐Varela, Valentina Durante , et al. · 2019

Objective Spreading depolarization (SD) is a transient self‐propagating wave of neuronal and glial depolarization coupled with large membrane ionic changes and a subsequent depression of neuronal activity. Spreading depolarization in the c…

NMDA receptor GluN2D subunit participates to levodopa-induced dyskinesia pathophysiology Open

Manuela Mellone, Elisa Zianni, Jennifer Stanic, Federica Campanelli, Gioia Marino , et al. · 2018

Alpha-Synuclein: From Early Synaptic Dysfunction to Neurodegeneration Open

Veronica Ghiglieri, Valeria Calabrese, Paolo Calabresi · 2018

Over the last two decades, many experimental and clinical studies have provided solid evidence that alpha-synuclein (α-syn), a small, natively unfolded protein, is closely related to Parkinson's disease (PD) pathology. To provide an overvi…

Motor learning and metaplasticity in striatal neurons: relevance for Parkinson’s disease Open

Nadia Giordano, Attilio Iemolo, Maria Mancini, Fabrizio Cacace, Maria De Risi , et al. · 2017

Nigro-striatal dopamine transmission is central to a wide range of neuronal functions, including skill learning, which is disrupted in several pathologies such as Parkinson's disease. The synaptic plasticity mechanisms, by which initial mo…

Rabphilin 3A: A novel target for the treatment of levodopa-induced dyskinesias Open

Jennifer Stanic, Manuela Mellone, Francesco Napolitano, Claudia Racca, Elisa Zianni , et al. · 2017

N-methyl-d-aspartate receptor (NMDAR) subunit composition strictly commands receptor function and pharmacological responses. Changes in NMDAR subunit composition have been documented in brain disorders such as Parkinson's disease (PD) and …

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