Verónica I. Dumit
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View article: Towards a harmonized testing strategy for nanofibers by integrating toxicological screening and proteomic profiling
Towards a harmonized testing strategy for nanofibers by integrating toxicological screening and proteomic profiling Open
Nanofibers, particularly multi-walled carbon nanotubes, have attracted attention for their exceptional properties, but concerns remain about their potential health hazards due to their fiber-like morphology. Although bio-durable nanofibers…
View article: Predicting the morphology-driven pathogenicity of nanofibers through proteomic profiling
Predicting the morphology-driven pathogenicity of nanofibers through proteomic profiling Open
View article: A refined dose metric for nanotoxicology based on surface site reactivity for oxidative potential of engineered nanomaterials
A refined dose metric for nanotoxicology based on surface site reactivity for oxidative potential of engineered nanomaterials Open
In chemico ENM reactivity assays quantify oxidative rates and reactive surface sites, refining dose metrics for nanotoxicity assessment and enabling safe-by-design nanomaterials.
View article: The dispersion method does not affect the in vitro genotoxicity of multi-walled carbon nanotubes despite inducing surface alterations
The dispersion method does not affect the in vitro genotoxicity of multi-walled carbon nanotubes despite inducing surface alterations Open
View article: Differentially Induced Autophagy by Engineered Nanomaterial Treatment Has an Impact on Cellular Homeostasis and Cytotoxicity
Differentially Induced Autophagy by Engineered Nanomaterial Treatment Has an Impact on Cellular Homeostasis and Cytotoxicity Open
Considering the increasing production of engineered nanomaterials (ENMs), new approach methodologies (NAMs) are essential for safe-by-design approaches and risk assessment. Our aim was to enhance screening strategies with a focus on reacti…
View article: Towards characterization of cell culture conditions for reliable proteomic analysis: in vitro studies on A549, differentiated THP-1, and NR8383 cell lines
Towards characterization of cell culture conditions for reliable proteomic analysis: in vitro studies on A549, differentiated THP-1, and NR8383 cell lines Open
Proteomic investigations result in high dimensional datasets, but integration or comparison of different studies is hampered by high variances due to different experimental setups. In addition, cell culture conditions can have a huge impac…
View article: Review of New Approach Methodologies for Application in Risk Assessment of Nanoparticles in the Food and Feed Sector: Status and Challenges
Review of New Approach Methodologies for Application in Risk Assessment of Nanoparticles in the Food and Feed Sector: Status and Challenges Open
New Approach Methodologies (NAMs), broadly understood to include in silico, in chemico, in vitro and ex vivo methods, show great potential in advancing risk assessment albeit their regulatory implementation is lagging. The EFSA Guidance on…
View article: Advancing Nanomaterial Toxicology Screening Through Efficient and Cost‐Effective Quantitative Proteomics
Advancing Nanomaterial Toxicology Screening Through Efficient and Cost‐Effective Quantitative Proteomics Open
Proteomic investigations yield high‐dimensional datasets, yet their application to large‐scale toxicological assessments is hindered by reproducibility challenges due to fluctuating measurement conditions. To address these limitations, thi…
View article: Governance of advanced materials: Shaping a safe and sustainable future
Governance of advanced materials: Shaping a safe and sustainable future Open
View article: Meta‐Analysis of Integrated Proteomic and Transcriptomic Data Discerns Structure–Activity Relationship of Carbon Materials with Different Morphologies
Meta‐Analysis of Integrated Proteomic and Transcriptomic Data Discerns Structure–Activity Relationship of Carbon Materials with Different Morphologies Open
The Fiber Pathogenicity Paradigm (FPP) establishes connections between fiber structure, durability, and disease‐causing potential observed in materials like asbestos and synthetic fibers. While emerging nanofibers are anticipated to exhibi…
View article: A comparative proteomics analysis of four contact allergens in THP-1 cells shows distinct alterations in key metabolic pathways
A comparative proteomics analysis of four contact allergens in THP-1 cells shows distinct alterations in key metabolic pathways Open
View article: From principles to reality. FAIR implementation in the nanosafety community
From principles to reality. FAIR implementation in the nanosafety community Open
View article: A computational view on nanomaterial intrinsic and extrinsic features for nanosafety and sustainability
A computational view on nanomaterial intrinsic and extrinsic features for nanosafety and sustainability Open
View article: PROTEOMAS: a workflow enabling harmonized proteomic meta-analysis and proteomic signature mapping
PROTEOMAS: a workflow enabling harmonized proteomic meta-analysis and proteomic signature mapping Open
View article: From Principles to Reality. FAIR Implementation in the Nanosafety Community
From Principles to Reality. FAIR Implementation in the Nanosafety Community Open
Nanoscience as a key enabling technology will be fundamental to address several of the current global challenges. Developing safe and sustainable solutions requires high quality data and appropriate analysis approaches. Therefore, implemen…
View article: Systems toxicology to advance human and environmental hazard assessment: A roadmap for advanced materials
Systems toxicology to advance human and environmental hazard assessment: A roadmap for advanced materials Open
View article: The Contact Allergen NiSO4 Triggers a Distinct Molecular Response in Primary Human Dendritic Cells Compared to Bacterial LPS
The Contact Allergen NiSO4 Triggers a Distinct Molecular Response in Primary Human Dendritic Cells Compared to Bacterial LPS Open
Dendritic cells (DC) play a central role in the pathogenesis of allergic contact dermatitis (ACD), the most prevalent form of immunotoxicity in humans. However, knowledge on allergy-induced DC maturation is still limited and proteomic stud…
View article: Proteomic Phosphosite Analysis Identified Crucial NPM-ALK-Mediated NIPA Serine and Threonine Residues
Proteomic Phosphosite Analysis Identified Crucial NPM-ALK-Mediated NIPA Serine and Threonine Residues Open
Anaplastic large-cell lymphoma (ALCL) is an aggressive non-Hodgkin lymphoma that shows in 60% of cases a translocation t(2;5)(p23;q35), which leads to the expression of the oncogenic kinase NPM-ALK. The nuclear interaction partner of ALK (…
View article: Issue Information
Issue Information Open
Wiley's Corporate Citizenship initiative seeks to address the environmental, social, economic, and ethical challenges faced in our business and which are important to our diverse stakeholder groups.Since launching the initiative, we have f…
View article: FOXG1 Regulates PRKAR2B Transcriptionally and Posttranscriptionally via miR200 in the Adult Hippocampus
FOXG1 Regulates PRKAR2B Transcriptionally and Posttranscriptionally via miR200 in the Adult Hippocampus Open
Rett syndrome is a complex neurodevelopmental disorder that is mainly caused by mutations in MECP2. However, mutations in FOXG1 cause a less frequent form of atypical Rett syndrome, called FOXG1 syndrome. FOXG1 is a key transcription facto…
View article: Influenza A Virus Induces Autophagosomal Targeting of Ribosomal Proteins
Influenza A Virus Induces Autophagosomal Targeting of Ribosomal Proteins Open
View article: Cilia‐localized <scp>LKB</scp> 1 regulates chemokine signaling, macrophage recruitment, and tissue homeostasis in the kidney
Cilia‐localized <span>LKB</span> 1 regulates chemokine signaling, macrophage recruitment, and tissue homeostasis in the kidney Open
View article: Mitochondrial fatty acid biosynthesis and muscle fiber plasticity in very long‐chain acyl‐CoA dehydrogenase‐deficient mice
Mitochondrial fatty acid biosynthesis and muscle fiber plasticity in very long‐chain acyl‐CoA dehydrogenase‐deficient mice Open
The white skeletal muscle of very long‐chain acyl‐CoA‐dehydrogenase‐deficient ( VLCAD −/− ) mice undergoes metabolic modification to compensate for defective β‐oxidation in a progressive and time‐dependent manner by upregulating glucose ox…
View article: Respiratory status determines the effect of emodin on cell viability
Respiratory status determines the effect of emodin on cell viability Open
The anthraquinone emodin has been shown to have antineoplastic properties and a wealth of unconnected effects have been linked to its use, most of which are likely secondary outcomes of the drug treatment. The primary activity of emodin on…
View article: Threading Granules in Freiburg
Threading Granules in Freiburg Open
Altered mitochondrial activities play an important role in many different human disorders, including cancer and neurodegeneration. At the Freiburg Institute of Advanced Studies (FRIAS) Junior Researcher Conference "One Mitochondrion, Many …
View article: <scp>SPATA</scp> 2 promotes <scp>CYLD</scp> activity and regulates <scp>TNF</scp> ‐induced <scp>NF</scp> ‐κB signaling and cell death
<span>SPATA</span> 2 promotes <span>CYLD</span> activity and regulates <span>TNF</span> ‐induced <span>NF</span> ‐κB signaling and cell death Open
View article: The balance of Id3 and E47 determines neural stem/precursor cell differentiation into astrocytes
The balance of Id3 and E47 determines neural stem/precursor cell differentiation into astrocytes Open
View article: Struggling for breath in Sherbrooke 1st Symposium on “One mitochondrion, many diseases” in Sherbrooke, Québec, Canada, March 11th, 2015
Struggling for breath in Sherbrooke 1st Symposium on “One mitochondrion, many diseases” in Sherbrooke, Québec, Canada, March 11th, 2015 Open
Struggling for breath in Sherbrooke: 1st Symposium on “One mitochondrion, many diseases” in Sherbrooke, Québec, Canada, March 11th, 2015 – MITOCHONDRIAL-DERIVED VESICLES IN MITOCHONDRIAL QUALITY CONTROL AND NEURODEGENERATION Heidi McBride …
View article: Modeling non-hereditary mechanisms of Alzheimer disease during apoptosis in yeast
Modeling non-hereditary mechanisms of Alzheimer disease during apoptosis in yeast Open
Impaired protein degradation and mitochondrial dysfunction are believed to contribute to neurodegenerative disorders, including Alzheimer disease (AD). In patients suffering from non-hereditary AD, UBB+1, the frameshift variant …
View article: Accumulation of Basic Amino Acids at Mitochondria Dictates the Cytotoxicity of Aberrant Ubiquitin
Accumulation of Basic Amino Acids at Mitochondria Dictates the Cytotoxicity of Aberrant Ubiquitin Open