Veronica Locher
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View article: Impact of disease-associated chromatin accessibility QTLs across immune cell types and contexts
Impact of disease-associated chromatin accessibility QTLs across immune cell types and contexts Open
Only one-third of immune-associated genome-wide association study (GWAS) loci colocalize with expression quantitative trait loci (eQTLs), leaving most mechanisms unresolved. To address this, we created a unified single-cell chromatin acces…
View article: Author Correction: β-Glucan reprograms neutrophils to promote disease tolerance against influenza A virus
Author Correction: β-Glucan reprograms neutrophils to promote disease tolerance against influenza A virus Open
View article: Impact of disease-associated chromatin accessibility QTLs across immune cell types and contexts
Impact of disease-associated chromatin accessibility QTLs across immune cell types and contexts Open
Only a third of immune-associated loci from genome-wide association studies (GWAS) colocalize with expression quantitative trait loci (eQTLs). To learn about causal genes and mechanisms at the remaining loci, we created a unified single-ce…
View article: Widespread gene-environment interactions shape the immune response to SARS-CoV-2 infection in hospitalized COVID-19 patients
Widespread gene-environment interactions shape the immune response to SARS-CoV-2 infection in hospitalized COVID-19 patients Open
Genome-wide association studies performed in patients with coronavirus disease 2019 (COVID-19) have uncovered various loci significantly associated with susceptibility to SARS-CoV-2 infection and COVID-19 disease severity. However, the und…
View article: Homeostatic cytokines reciprocally modulate the emergence of prenatal effector PLZF+CD4+ T cells in humans
Homeostatic cytokines reciprocally modulate the emergence of prenatal effector PLZF+CD4+ T cells in humans Open
The development of human adaptive immunity progresses faster than previously appreciated, with the emergence of memory CD4 + T cells alongside regulatory T (Treg) cells by the second trimester of pregnancy. We previously identified a prena…