Verónica Miksztowicz
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View article: Guidelines for Diet-Induced Models of Cardiometabolic Syndrome
Guidelines for Diet-Induced Models of Cardiometabolic Syndrome Open
Cardiometabolic syndrome (CMS) encompasses a cluster of metabolic abnormalities, including obesity, insulin resistance, dyslipidemia, and hypertension that collectively increase the risk of cardiovascular disease and type 2 diabetes. Anima…
View article: High Salt Intake Affects Visceral Adipose Tissue Homeostasis: Beneficial Effects of GLP-1 Agonists
High Salt Intake Affects Visceral Adipose Tissue Homeostasis: Beneficial Effects of GLP-1 Agonists Open
High salt (NaCl) intake has been associated with visceral adipose tissue (VAT) dysfunction independently of its impact on blood pressure. Liraglutide (LGT), a GLP-1 agonist, could be a potential therapeutic option. We investigated the impa…
View article: Liraglutide improves adipose tissue remodeling and mitochondrial dynamics in a visceral obesity model induced by a high-fat diet
Liraglutide improves adipose tissue remodeling and mitochondrial dynamics in a visceral obesity model induced by a high-fat diet Open
View article: Unraveling the role of galectin-3 in cardiac pathology and physiology
Unraveling the role of galectin-3 in cardiac pathology and physiology Open
Galectin-3 (Gal-3) is a carbohydrate-binding protein with multiple functions. Gal-3 regulates cell growth, proliferation, and apoptosis by orchestrating cell-cell and cell-matrix interactions. It is implicated in the development and progre…
View article: Effect of fried sunflower oil intake on mandibular biomechanical competence of growing rats
Effect of fried sunflower oil intake on mandibular biomechanical competence of growing rats Open
Previous studies by us demonstrated that the consumption of thermally oxidized oil diet adversely affects body growth, lipid metabolism, bone mass and femur biomechanical competence. Aim: The aim of this study was to evaluate the effects o…
View article: An Experimental Model of Myocardial Infarction for Studying Cardiac Repair and Remodeling in Knockout Mice
An Experimental Model of Myocardial Infarction for Studying Cardiac Repair and Remodeling in Knockout Mice Open
Cardiovascular disease is the most prevalent cause of death in Western countries, with acute myocardial infarction (MI) being the most prevalent form. This paper describes a protocol for studying the role of galectin 3 (Gal-3) in the tempo…
View article: Genetic Deletion of Galectin-3 Exacerbates Age-Related Myocardial Hypertrophy and Fibrosis in Mice
Genetic Deletion of Galectin-3 Exacerbates Age-Related Myocardial Hypertrophy and Fibrosis in Mice Open
Background/Aims: Aging is accompanied by progressive and adverse cardiac remodeling characterized by myocardial hypertrophy, fibrosis, and dysfunction. We previously reported that galectin-3 (Gal-3) is a critical regulator of inflammation …
View article: Epicardial Adipose Tissue Ceramides Are Related to Lipoprotein Lipase Activity in Coronary Artery Disease: Unfolding a Missing Link
Epicardial Adipose Tissue Ceramides Are Related to Lipoprotein Lipase Activity in Coronary Artery Disease: Unfolding a Missing Link Open
Background: Epicardial adipose tissue (EAT) contributes to coronary artery disease (CAD). EAT presents a specific lipidomic signature, showing increased ceramides and other proinflammatory lipids content. Besides, LPL (lipoprotein lipase) …
View article: Table of Contents
Table of Contents Open
View article: Genetic Deletion of Galectin-3 Alters the Temporal Evolution of Macrophage Infiltration and Healing Affecting the Cardiac Remodeling and Function after Myocardial Infarction in Mice
Genetic Deletion of Galectin-3 Alters the Temporal Evolution of Macrophage Infiltration and Healing Affecting the Cardiac Remodeling and Function after Myocardial Infarction in Mice Open
View article: Untargeted Lipidomics Reveals a Specific Enrichment in Plasmalogens in Epicardial Adipose Tissue and a Specific Signature in Coronary Artery Disease
Untargeted Lipidomics Reveals a Specific Enrichment in Plasmalogens in Epicardial Adipose Tissue and a Specific Signature in Coronary Artery Disease Open
Objective: Epicardial adipose tissue (EAT) is an active endocrine organ that could contribute to the pathophysiology of coronary artery disease (CAD) through the paracrine release of proatherogenic mediators. Numerous works have analyzed t…
View article: Behavior of Metalloproteinases in Adipose Tissue, Liver and Arterial Wall: An Update of Extracellular Matrix Remodeling
Behavior of Metalloproteinases in Adipose Tissue, Liver and Arterial Wall: An Update of Extracellular Matrix Remodeling Open
Extracellular matrix (ECM) remodeling is required for many physiological and pathological processes. Metalloproteinases (MMPs) are endopeptidases which are able to degrade different components of the ECM and nucleus matrix and to cleave nu…
View article: Endothelial Lipase Is an Alternative Pathway for Fatty Acid Release from Lipoproteins: Evidence from a High Fat Diet Model of Obesity in Rats
Endothelial Lipase Is an Alternative Pathway for Fatty Acid Release from Lipoproteins: Evidence from a High Fat Diet Model of Obesity in Rats Open
Lipoprotein lipase (LPL) and endothelial lipase (EL) are involved in lipoprotein metabolism. In insulin‐resistance, their behavior is altered. Peroxisome proliferator‐activated receptors (PPAR) and apoproteins (apo)CII and CIII could be pa…
View article: Actividad de lipoproteína lipasa en el tejido adiposo epicárdico de pacientes con enfermedad coronaria: ¿Es determinante de la composición de las lipoproteínas de muy baja densidad circulantes?
Actividad de lipoproteína lipasa en el tejido adiposo epicárdico de pacientes con enfermedad coronaria: ¿Es determinante de la composición de las lipoproteínas de muy baja densidad circulantes? Open
Introducción: El tejido adiposo epicárdico (TAE) es un tejido adiposovisceral, metabólicamente activo, cuyo aumento de volumen se asociacon mayor riesgo de enfermedad coronaria (EC). La lipoproteína lipasa(LPL) es la enzima encargada de hi…
View article: Nonalcoholic fatty liver disease associated with metabolic syndrome: Influence of liver fibrosis stages on characteristics of very low-density lipoproteins
Nonalcoholic fatty liver disease associated with metabolic syndrome: Influence of liver fibrosis stages on characteristics of very low-density lipoproteins Open
View article: Erratum: Circulating Very-Low-Density Lipoprotein Characteristics Resulting from Fatty Liver in an Insulin Resistance Rat Model
Erratum: Circulating Very-Low-Density Lipoprotein Characteristics Resulting from Fatty Liver in an Insulin Resistance Rat Model Open
The close association between nonalcoholic fatty liver and insulin resistance is now widely recognized. While the former is characterized by excessive intrahepatic triglyceride accumulation, the latter induces overproduction of very-low-de…
View article: Adiponectina determinaría el predominio de VLDL alteradas en el síndrome metabólico
Adiponectina determinaría el predominio de VLDL alteradas en el síndrome metabólico Open
El objetivo del trabajo fue evaluar si la reducción de adiponectina (ADP) en el síndrome metabólico (SMet), influencia las características aterogénicas de VLDL. Se estudiaron 45 pacientes con SMet y 15 controles sanos. En suero en ayunas s…
View article: Relationship between endothelial progenitor cells and vascular endothelial growth factor and its variation with exercise
Relationship between endothelial progenitor cells and vascular endothelial growth factor and its variation with exercise Open
View article: Metalloproteinases in the pathogenesis and progression of metabolic syndrome: potential targets for improved outcomes
Metalloproteinases in the pathogenesis and progression of metabolic syndrome: potential targets for improved outcomes Open
Matrix metalloproteinases (MMPs) constitute a family of more than 25 calcium-dependent, zinc-containing endopeptidases, synthesized by multiple cell types. These enzymes play an important role during physiological tissue development and re…
View article: Matrix metalloproteinases and psychosocial factors in acute coronary syndrome patients
Matrix metalloproteinases and psychosocial factors in acute coronary syndrome patients Open
View article: Variaciones de los niveles plasmáticos de VEGF con el ejercicio en pacientes con enfermedad coronaria crónica
Variaciones de los niveles plasmáticos de VEGF con el ejercicio en pacientes con enfermedad coronaria crónica Open
The aim of this study was to assess the effect of acute and programmed physical exercise on plasma VEGF levels in chronic stable coronary artery disease pat...