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View article: The Utility of Immuno-Nutritional Scores in Patients with Testicular Germ Cell Tumors
The Utility of Immuno-Nutritional Scores in Patients with Testicular Germ Cell Tumors Open
Background: Hemoglobin, Albumin, Lymphocyte, and Platelet Score (HALP) is an accessible score that is easily reproducible from routine laboratory testing while also reflecting patients’ immune-nutritional status. Along with other immuno-nu…
View article: The Role of Glutathione Transferase Omega-Class Variant Alleles in Individual Susceptibility to Ovarian Cancer
The Role of Glutathione Transferase Omega-Class Variant Alleles in Individual Susceptibility to Ovarian Cancer Open
The tumor microenvironment is affected by reactive oxygen species and has been suggested to have an important role in ovarian cancer (OC) tumorigenesis. The role of glutathione transferases (GSTs) in the maintenance of redox balance is con…
View article: #941 Pentraxin-3 as a marker of coronary artery disease in hemodialysis patients
#941 Pentraxin-3 as a marker of coronary artery disease in hemodialysis patients Open
Background and Aims Pentraxin-3 (PTX3), a novel inflammatory biomarker, has been recognized as a predictor of cardiovascular events in the general population, including coronary artery disease (CAD). Although PTX3 is elevated in dialysis p…
View article: GSTM1 and GSTP1 Polymorphisms Affect Outcome in Colorectal Adenocarcinoma
GSTM1 and GSTP1 Polymorphisms Affect Outcome in Colorectal Adenocarcinoma Open
Background and Objectives: Despite improvements in screening programs, a large number of patients with colorectal cancer (CRC) are diagnosed in an advanced disease stage. Previous investigations imply that glutathione transferases (GSTs) m…
View article: Multifocality in Testicular Cancer: Clinicopathological Correlations and Prognostic Implications
Multifocality in Testicular Cancer: Clinicopathological Correlations and Prognostic Implications Open
There are limited data regarding the significance of multifocality in testicular cancer patients. This study evaluated the relationship between multifocality and clinicopathological features determined at the time of radical orchiectomy. T…
View article: Indicators of inflammatory, multiorgan impairment and redox biomarkers and CT findings in patients with COVID-19 pneumonia
Indicators of inflammatory, multiorgan impairment and redox biomarkers and CT findings in patients with COVID-19 pneumonia Open
Coronavirus disease 2019 (COVID-19) is a multi-systemic disease caused by Severe acute respiratory syndrome coronavirus 2, SARS-CoV-2. Since the onset of the pandemic, understanding the pathophysiological mechanisms of this disease has pos…
View article: The role of oxidative stress in ovarian cancer pathogenesis
The role of oxidative stress in ovarian cancer pathogenesis Open
Ovarian cancer is the deadliest form of gynecological malignancy. The presence of non-specific symptoms, together with the identification of the disease in an advanced stage, are the primary determinants of an unfavorable prognosis, result…
View article: Tumor Markers in Early Detection and Monitoring of Prostate Cancer: Recent Advances
Tumor Markers in Early Detection and Monitoring of Prostate Cancer: Recent Advances Open
Due to the fact that the use of prostate-specific antigen (PSA) in prostate cancer (PC) management is limited, the search for novel biomarkers useful for early detection and monitoring, especially from noninvasive biofluids is an important…
View article: GPX3 Variant Genotype Affects the Risk of Developing Severe Forms of COVID-19
GPX3 Variant Genotype Affects the Risk of Developing Severe Forms of COVID-19 Open
In SARS-CoV-2 infection, excessive activation of the immune system intensively increases reactive oxygen species levels, causing harmful hyperinflammatory and oxidative state cumulative effects which may contribute to COVID-19 severity. Th…
View article: GPX3 rs8177412 Polymorphism Modifies Risk of Upper Urothelial Tumors in Patients with Balkan Endemic Nephropathy
GPX3 rs8177412 Polymorphism Modifies Risk of Upper Urothelial Tumors in Patients with Balkan Endemic Nephropathy Open
Current data suggest that aristolochic acid (AA) exposure is a putative cause of Balkan endemic nephropathy (BEN), a chronic kidney disease strongly associated with upper tract urothelial carcinoma. The cellular metabolism of AA is associa…
View article: Antioxidant Genetic Variants Modify Echocardiography Indices in Long COVID
Antioxidant Genetic Variants Modify Echocardiography Indices in Long COVID Open
Although disturbance of redox homeostasis might be responsible for COVID-19 cardiac complications, this molecular mechanism has not been addressed yet. We have proposed modifying the effects of antioxidant proteins polymorphisms (superoxid…
View article: The Polymorphisms in GSTO Genes (GSTO1 rs4925, GSTO2 rs156697, and GSTO2 rs2297235) Affect the Risk for Testicular Germ Cell Tumor Development: A Pilot Study
The Polymorphisms in GSTO Genes (GSTO1 rs4925, GSTO2 rs156697, and GSTO2 rs2297235) Affect the Risk for Testicular Germ Cell Tumor Development: A Pilot Study Open
Members of the omega class of glutathione transferases (GSTs), GSTO1, and GSTO2, catalyze a range of reduction reactions as a part of the antioxidant defense system. Polymorphisms of genes encoding antioxidant proteins and the resultant al…
View article: Prognostic Significance of Systemic Inflammation Markers in Testicular and Penile Cancer: A Narrative Review of Current Literature
Prognostic Significance of Systemic Inflammation Markers in Testicular and Penile Cancer: A Narrative Review of Current Literature Open
In contemporary clinical practice, biomarkers are indispensable in the assessment and management of oncological patients. Although established serum tumor markers (beta human chorionic gonadotropin (bHCG), alpha fetoprotein (AFP), and lact…
View article: The implications of oxidative stress in long COVID pathogenesis
The implications of oxidative stress in long COVID pathogenesis Open
As far as clinical presentation is concerned, following an episode of acute sickness, the SARS-CoV-2 infection may lead to the development of a number of complications known as post-acute sequelae of SARS-CoV-2 infection (PASC). The defini…
View article: Glutathione Transferase P1: Potential Therapeutic Target in Ovarian Cancer
Glutathione Transferase P1: Potential Therapeutic Target in Ovarian Cancer Open
Chemotherapy resistance of ovarian cancer, regarded as the most lethal malignant gynecological disease, can be explained by several mechanisms, including increased activity of efflux transporters leading to decreased intracellular drug acc…
View article: The Association of Polymorphisms in Genes Encoding Antioxidant Enzymes GPX1 (rs1050450), SOD2 (rs4880) and Transcriptional Factor Nrf2 (rs6721961) with the Risk and Development of Prostate Cancer
The Association of Polymorphisms in Genes Encoding Antioxidant Enzymes GPX1 (rs1050450), SOD2 (rs4880) and Transcriptional Factor Nrf2 (rs6721961) with the Risk and Development of Prostate Cancer Open
Background and Objectives: Mounting evidence implicates oxidative damage in prostate carcinogenesis, contributing to modifications of macromolecules that drive cellular malignant transformation. Functional single-nucleotide polymorphisms (…
View article: Interplay between Comprehensive Inflammation Indices and Redox Biomarkers in Testicular Germ-Cell Tumors
Interplay between Comprehensive Inflammation Indices and Redox Biomarkers in Testicular Germ-Cell Tumors Open
Sustained and dysregulated inflammation, concurrent tumor-induced immune suppression, and oxidative stress are profoundly involved in cancer initiation, presentation, and perpetuation. Within this prospective study, we simultaneously analy…
View article: Antioxidant Genetic Profile Modifies Probability of Developing Neurological Sequelae in Long-COVID
Antioxidant Genetic Profile Modifies Probability of Developing Neurological Sequelae in Long-COVID Open
Understanding the sequelae of COVID-19 is of utmost importance. Neuroinflammation and disturbed redox homeostasis are suggested as prevailing underlying mechanisms in neurological sequelae propagation in long-COVID. We aimed to investigate…
View article: <i>SOD2</i> rs4880 and <i>GPX1</i> rs1050450 polymorphisms do not confer risk of COVID-19, but influence inflammation or coagulation parameters in Serbian cohort
<i>SOD2</i> rs4880 and <i>GPX1</i> rs1050450 polymorphisms do not confer risk of COVID-19, but influence inflammation or coagulation parameters in Serbian cohort Open
Objectives: Due to the role of oxidative stress in the pathophysiology of COVID-19, it is biologically plausible that inter-individual differences in patients' clinical manifestations might be affected by antioxidant genetic profile. The a…
View article: GSTO1, GSTO2 and ACE2 Polymorphisms Modify Susceptibility to Developing COVID-19
GSTO1, GSTO2 and ACE2 Polymorphisms Modify Susceptibility to Developing COVID-19 Open
Based on the close relationship between dysregulation of redox homeostasis and immune response in SARS-CoV-2 infection, we proposed a possible modifying role of ACE2 and glutathione transferase omega (GSTO) polymorphisms in the individual …
View article: The Polymorphisms of Genes Encoding Catalytic Antioxidant Proteins Modulate the Susceptibility and Progression of Testicular Germ Cell Tumor
The Polymorphisms of Genes Encoding Catalytic Antioxidant Proteins Modulate the Susceptibility and Progression of Testicular Germ Cell Tumor Open
The simultaneous analysis of redox biomarkers and polymorphisms encoding for regulatory and catalytic antioxidant proteins was performed in order to evaluate their potential role in the development of testicular germ cell tumor (GCT), as w…
View article: The association of glutathione transferase omega polymorphisms with laboratory inflammatory parameters in COVID-19
The association of glutathione transferase omega polymorphisms with laboratory inflammatory parameters in COVID-19 Open
In a view of important functions of glutathione transferase omega (GSTO) class in redox homeostasis and innate immunity, it was proposed that interindividual differences in COVID-19 clinical manifestations might be affected by GSTO1 (rs492…
View article: Treatment options in stage I seminoma
Treatment options in stage I seminoma Open
Seminomas are most commonly diagnosed in clinical stage I (CSI). After orchiectomy, approximately 15% of patients in this stage have subclinical metastases. Adjuvant radiotherapy (ART) delivered to the retroperitoneum and ipsilateral pelvi…
View article: The association of SOD2 and GST gene polymorphisms with the risk of development and prognosis of papillary renal cell carcinoma
The association of SOD2 and GST gene polymorphisms with the risk of development and prognosis of papillary renal cell carcinoma Open
Introduction: Redox imbalance is an important factor in both carcinogenesis and progression of renal cell carcinoma. Numerous studies are focused on finding potential biomarkers that can aid in early detection, as well as in monitoring dis…
View article: GSTP1 and GSTM3 Variant Alleles Affect Susceptibility and Severity of COVID-19
GSTP1 and GSTM3 Variant Alleles Affect Susceptibility and Severity of COVID-19 Open
Based on the premise that oxidative stress plays an important role in severe acute respiratory syndrome coronavirus (SARS-CoV-2) infection, we speculated that variations in the antioxidant activities of different members of the glutathione…
View article: Time Course of Redox Biomarkers in COVID-19 Pneumonia: Relation with Inflammatory, Multiorgan Impairment Biomarkers and CT Findings
Time Course of Redox Biomarkers in COVID-19 Pneumonia: Relation with Inflammatory, Multiorgan Impairment Biomarkers and CT Findings Open
Although the original data on systemic oxidative stress in COVID-19 patients have recently started to emerge, we are still far from a complete profile of changes in patients’ redox homeostasis. We aimed to assess the extent of oxidative da…
View article: The Association of Polymorphisms in <i>Nrf2</i> and Genes Involved in Redox Homeostasis in the Development and Progression of Clear Cell Renal Cell Carcinoma
The Association of Polymorphisms in <i>Nrf2</i> and Genes Involved in Redox Homeostasis in the Development and Progression of Clear Cell Renal Cell Carcinoma Open
Deleterious effects of SNPs found in genes encoding transcriptional factors, as well as antioxidant and detoxification enzymes, are disputable; however, their functional significance seems to modify the risk for clear cell renal cell carci…
View article: GSTO1*CC Genotype (rs4925) Predicts Shorter Survival in Clear Cell Renal Cell Carcinoma Male Patients
GSTO1*CC Genotype (rs4925) Predicts Shorter Survival in Clear Cell Renal Cell Carcinoma Male Patients Open
Omega class glutathione transferases, GSTO1-1 and GSTO2-2, exhibit different activities involved in regulation of inflammation, apoptosis and redox homeostasis. We investigated the the prognostic significance of GSTO1 (rs4925) and GSTO2 (r…