Vibeke Wewer
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View article: Tissue-specific microRNA signatures in pediatric inflammatory bowel disease with juvenile idiopathic arthritis: differential expression and cross-platform evaluation
Tissue-specific microRNA signatures in pediatric inflammatory bowel disease with juvenile idiopathic arthritis: differential expression and cross-platform evaluation Open
Background & Aim Development of extraintestinal manifestations in pediatric inflammatory bowel disease (pIBD) is associated with a more severe disease course; juvenile idiopathic arthritis (JIA) is the most frequent extraintestinal manifes…
View article: How early-life adversity affects the risk of pediatric-onset immune-mediated inflammatory disease
How early-life adversity affects the risk of pediatric-onset immune-mediated inflammatory disease Open
Early-life biological adversities are important risk factors for developing pIMID. The lower risk observed in the familial dimension was unexpected but may reflect delayed diagnosis in socially vulnerable families. This potential inequalit…
View article: Gut microbiota diversity repeatedly diminishes over time following maintenance infliximab infusions in paediatric IBD patients
Gut microbiota diversity repeatedly diminishes over time following maintenance infliximab infusions in paediatric IBD patients Open
Background The gut microbiome plays a crucial role in the pathogenesis and progression of inflammatory bowel disease (IBD). Understanding the dynamics of the gut microbiome in relation to treatment can provide valuable insights into diseas…
View article: The risk of cancer in pediatric-onset immune-mediated inflammatory diseases – A nationwide study
The risk of cancer in pediatric-onset immune-mediated inflammatory diseases – A nationwide study Open
We found an increased cancer risk in patients with pIMID followed into adulthood. Additionally, thiopurines and anti-TNFα were associated with increased lymphoma and skin cancer risks. This highlights the importance of individualized immun…
View article: Thiopurines and the Risk of Cancer in Patients With Inflammatory Bowel Disease and Reference Individuals Without Inflammatory Bowel Disease: A Danish Nationwide Cohort Study (1996-2018)
Thiopurines and the Risk of Cancer in Patients With Inflammatory Bowel Disease and Reference Individuals Without Inflammatory Bowel Disease: A Danish Nationwide Cohort Study (1996-2018) Open
Thiopurines were associated with increased hazard of cancer, especially when used in combination therapy in the elderly. The hazard increased by 36% when patients were exposed to thiopurines for more than 5 years. Reassuringly, the hazard …
View article: Treatment of inflammatory bowel disease with steroid‐sparing medications is age‐dependent – Results from a Danish nationwide cohort study, 2000–2018
Treatment of inflammatory bowel disease with steroid‐sparing medications is age‐dependent – Results from a Danish nationwide cohort study, 2000–2018 Open
Summary Background Paediatric‐onset and elderly‐onset inflammatory bowel disease (IBD) present unique treatment challenges. Aims We investigated treatment patterns following a first and second course of systemic steroids in paediatric‐ and…
View article: Identification and validation of a blood- based diagnostic lipidomic signature of pediatric inflammatory bowel disease
Identification and validation of a blood- based diagnostic lipidomic signature of pediatric inflammatory bowel disease Open
Improved biomarkers are needed for pediatric inflammatory bowel disease. Here we identify a diagnostic lipidomic signature for pediatric inflammatory bowel disease by analyzing blood samples from a discovery cohort of incident treatment-na…
View article: Paediatric‐onset <scp>immune‐mediated</scp> inflammatory disease is associated with an increased mortality risk—A nationwide study
Paediatric‐onset <span>immune‐mediated</span> inflammatory disease is associated with an increased mortality risk—A nationwide study Open
Summary Background Paediatric‐onset immune‐mediated inflammatory diseases (pIMID) show more aggressive phenotypes than when diagnosed in adults. However, data on mortality are often extrapolated from adult studies. Aim To estimate the effe…
View article: P913 Intestinal Ultrasound in paediatric Crohn’s disease reduces the need for subsequent ileocolonoscopy
P913 Intestinal Ultrasound in paediatric Crohn’s disease reduces the need for subsequent ileocolonoscopy Open
Background Approximately 20% of patients with Crohn's disease (CD) are diagnosed during childhood (pCD). At diagnosis, the vast majority (87%) of patients with pCD demonstrate severe disease activity.(1) Severe disease activity necessitate…
View article: P1166 Thiopurines and Risk of Cancer in Patients with Inflammatory Bowel Disease -A Danish Nationwide Cohort study 1996-2018
P1166 Thiopurines and Risk of Cancer in Patients with Inflammatory Bowel Disease -A Danish Nationwide Cohort study 1996-2018 Open
Background Thiopurines are frequently used in patients with inflammatory bowel disease (IBD). The aim of this study was to assess the cancer risk of thiopurine monotherapy and thiopurine in combination with biologics compared to unexposed …
View article: Pre- and perinatal exposures associated with developing pediatric-onset immune-mediated inflammatory disease: A Danish nation-wide cohort study
Pre- and perinatal exposures associated with developing pediatric-onset immune-mediated inflammatory disease: A Danish nation-wide cohort study Open
Our results indicate a high genetic burden in pIMID but also identifies intervenable risk factors, such as Cesarean section. Physicians should, keep this in mind when caring for high-risk populations and pregnant women previously diagnosed…
View article: DOP21 Disease activity patterns of paediatric Inflammatory Bowel Disease – A Danish nationwide cohort study 1996-2018
DOP21 Disease activity patterns of paediatric Inflammatory Bowel Disease – A Danish nationwide cohort study 1996-2018 Open
Background Inflammatory bowel diseases (IBD) are heterogenous diseases in terms of their clinical presentation including frequency and severity of flares. We aimed to describe disease activity (DA) patterns in a Danish nationwide cohort in…
View article: DOP20 The impact of early life antibiotics on the occurrence of paediatric inflammatory bowel disease - a nationwide study from 1995 – 2018
DOP20 The impact of early life antibiotics on the occurrence of paediatric inflammatory bowel disease - a nationwide study from 1995 – 2018 Open
Background Early–life antibiotic exposure has been associated with a decreased richness of the microbiome, which is associated with the development of inflammatory bowel disease (IBD). The aim of this study was to assess the risk of develo…
View article: OP22 The risk of cancer in pediatric-onset immune-mediated inflammatory diseases – a nationwide Danish study from 1980-2018.
OP22 The risk of cancer in pediatric-onset immune-mediated inflammatory diseases – a nationwide Danish study from 1980-2018. Open
Background A higher risk of cancer has been reported among patients with adult-onset immune-mediated inflammatory disease (IMID). However, data on cancer risk in paediatric-onset IMIDs (pIMID) are scarce. In this nationwide study from 1980…
View article: The Incidence and Prevalence of Paediatric- and Adult-Onset Inflammatory Bowel Disease in Denmark During a 37-Year Period: A Nationwide Cohort Study (1980–2017)
The Incidence and Prevalence of Paediatric- and Adult-Onset Inflammatory Bowel Disease in Denmark During a 37-Year Period: A Nationwide Cohort Study (1980–2017) Open
Background Incidence rates of inflammatory bowel disease [IBD] reported from developed countries are rising, with some levelling out. The aim of this study was to assess the disease burden of IBD by estimating the incidence and prevalence …
View article: Incidence, Disease Course, and Medical Treatment of a Danish Population-Based Cohort of Very Early-Onset Inflammatory Bowel Disease
Incidence, Disease Course, and Medical Treatment of a Danish Population-Based Cohort of Very Early-Onset Inflammatory Bowel Disease Open
Background and Aims. In very early-onset IBD patients (VEO-IBD), studies have shown an incidence ranging from 0.4 to 2.1/100,000, extensive disease location, and a corresponding difficult and debatable treatment. We therefore aimed to inve…
View article: Paediatric Crohn’s Disease Patients Have Increased Inflammatory Markers Compared to Adult Patients prior to Biological Treatment
Paediatric Crohn’s Disease Patients Have Increased Inflammatory Markers Compared to Adult Patients prior to Biological Treatment Open
Background. Recent epidemiological studies in inflammatory bowel disease (IBD) indicate that paediatric onset of IBD (pIBD) more often requires biological therapy compared to adult onset of IBD (aIBD). Whether this is due to a more aggress…
View article: Transition of Adolescents with Inflammatory Bowel Disease—Are the Pediatric Teams up to the Task?
Transition of Adolescents with Inflammatory Bowel Disease—Are the Pediatric Teams up to the Task? Open
Our aim was to describe the challenges of the transition process of adolescents with inflammatory bowel disease (IBD), as seen from a pediatric-care perspective, to clarify the key obstacles and propose how to move forward. Semi-structured…
View article: P501 Incidence and therapeutic management/treatment of very early onset inflammatory bowel disease during 2015–2020
P501 Incidence and therapeutic management/treatment of very early onset inflammatory bowel disease during 2015–2020 Open
Background To investigate the incidence of very early onset inflammatory bowel disease (VEO-IBD) in a cohort representing two regions in Denmark during the period 2015–2019 and to assess the medical and surgical treatment. Methods All pati…
View article: Mucosal microRNAs relate to age and severity of disease in ulcerative colitis
Mucosal microRNAs relate to age and severity of disease in ulcerative colitis Open
Despite significant evidence that the expression of several microRNAs (miRNAs) impacts disease activity in patients with ulcerative colitis (UC), it remains unknown if the more severe disease phenotype seen in pediatric onset UC can be exp…
View article: THE MUCOSAL MICRORNA PROFILE RELATES TO AGE AND SEVERITY OF DISEASE IN PATIENTS WITH ULCERATIVE COLITIS
THE MUCOSAL MICRORNA PROFILE RELATES TO AGE AND SEVERITY OF DISEASE IN PATIENTS WITH ULCERATIVE COLITIS Open
Despite significant evidence that the expression of several microRNA’s (miRNA) impacts on disease activity in patients with ulcerative colitis (UC), it remains unknown if the more severe disease phenotype seen in pediatric-onset UC can be …
View article: Letter: suicide risk among adult inflammatory bowel disease patients. Authors' reply
Letter: suicide risk among adult inflammatory bowel disease patients. Authors' reply Open
LINKED CONTENT This article is linked to Malham et al and Sánta papers. To view these articles, visit https://doi.org/10.1111/apt.15258 and https://doi.org/10.1111/apt.15708 .
View article: Editorial: suicide and IBD—a call to action. Authors’ reply
Editorial: suicide and IBD—a call to action. Authors’ reply Open
Linked Content This article is linked to Malham et al and Banerjee and Gearry papers. To view these articles, visit https://doi.org/10.1111/apt.15258 and https://doi.org/10.1111/apt.15299 .
View article: The incidence of cancer and mortality in paediatric onset inflammatory bowel disease in Denmark and Finland during a 23‐year period: a population‐based study
The incidence of cancer and mortality in paediatric onset inflammatory bowel disease in Denmark and Finland during a 23‐year period: a population‐based study Open
Summary Background Recent studies report increased risks of both cancer and mortality in paediatric onset inflammatory bowel disease (pIBD) but the reproducibility of this is unknown. Aim To estimate the risk of cancer and mortality in the…
View article: A Personalized eHealth Transition Concept for Adolescents With Inflammatory Bowel Disease: Design of Intervention
A Personalized eHealth Transition Concept for Adolescents With Inflammatory Bowel Disease: Design of Intervention Open
We have conducted a personalized eHealth transition concept consisting of basic elements that measure, train, and monitor the patients' transition readiness. The concept can be implemented and adjusted to local conditions.
View article: P777 The cancer incidence in paediatric onset inflammatory bowel disease: a population-based study from Denmark
P777 The cancer incidence in paediatric onset inflammatory bowel disease: a population-based study from Denmark Open
The incidence of colorectal cancer (CRC) in IBD has been the subject of much debate over the last decades and seems to have decreased to a negligible [1].However, in most studies sub-analysis revealed young age at diagnosis to be a risk fa…
View article: Serum Calprotectin in Adolescents With Inflammatory Bowel Disease—A Pilot Investigation
Serum Calprotectin in Adolescents With Inflammatory Bowel Disease—A Pilot Investigation Open
Objectives: Fecal calprotectin (FC) is a well‐integrated parameter in the monitoring of adolescent patients with inflammatory bowel disease (IBD). However, measurement of FC is limited by day‐to‐day‐variation and by the feces consistency. …
View article: DOP045. Self-administered telemedicine empowers paediatric and adolescent patients with Inflammatory Bowel Disease
DOP045. Self-administered telemedicine empowers paediatric and adolescent patients with Inflammatory Bowel Disease Open
Methods:In this multicentre, 12-month prospective study, outpatients with IBD were included.Demographic and clinical characteristics were recorded.Adherence was measured with the Modified Morisky Adherence Scale-8 (MMAS-8) and 12-month pha…
View article: P587. SuPREMe-CD Study: surgical prevention of anastomotic recurrence by excluding mesentery in Crohn’s disease—preliminary results and trial protocol
P587. SuPREMe-CD Study: surgical prevention of anastomotic recurrence by excluding mesentery in Crohn’s disease—preliminary results and trial protocol Open
Background: Although new strategies have been introduced in the therapy of Crohn's disease (CD), patients remain refractory to current regimens including tumour necrosis factor (TNF) antibodies.Previous data from single-centre studies indi…
View article: P586. Cyclophosphamide pulse therapy in severe refractory Crohn’s disease
P586. Cyclophosphamide pulse therapy in severe refractory Crohn’s disease Open
Background:The objective of this study was to investigate the success of planned anti-tumour necrosis factor (TNF) withdrawal in a real-life cohort of Crohn's disease (CD) and ulcerative colitis (UC) patients in sustained clinical remissio…