Vijay Hegde
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View article: Peripheral Mitochondrial Dysfunction: A Potential Contributor to the Development of Metabolic Disorders and Alzheimer’s Disease
Peripheral Mitochondrial Dysfunction: A Potential Contributor to the Development of Metabolic Disorders and Alzheimer’s Disease Open
Alzheimer’s disease (AD) is a progressive neurodegenerative disease characterized by loss of function and eventual death of neurons in the brain. Multiple studies have highlighted the involvement of mitochondria in the initiation and advan…
View article: Branched-Chain Amino Acids Are Linked with Alzheimer’s Disease-Related Pathology and Cognitive Deficits
Branched-Chain Amino Acids Are Linked with Alzheimer’s Disease-Related Pathology and Cognitive Deficits Open
Alzheimer’s disease (AD) is an irreversible neurodegenerative disorder with a complex pathophysiology. Type 2 diabetes (T2D) is a strong risk factor for AD that shares similar abnormal features including metabolic dysregulation and brain p…
View article: E4orf1 Prevents Progression of Fatty Liver Disease in Mice on High Fat Diet
E4orf1 Prevents Progression of Fatty Liver Disease in Mice on High Fat Diet Open
Non-alcoholic fatty liver disease (NAFLD) covers a broad spectrum of liver diseases ranging from steatosis to cirrhosis. There are limited data on prevention of hepatic steatosis or its progression to liver disease. Here, we tested if eith…
View article: Protective Effects of Chaya against Mitochondrial and Synaptic Toxicities in the Type 2 Diabetes Mouse Model TallyHO
Protective Effects of Chaya against Mitochondrial and Synaptic Toxicities in the Type 2 Diabetes Mouse Model TallyHO Open
The purpose of our study is to determine the protective effects of the chaya leaf against mitochondrial abnormalities and synaptic damage in the Type 2 diabetes (T2D) mouse model, TallyHO (TH). The TH mouse is a naturally occurring polygen…
View article: Cardiometabolic Modification of Amyloid Beta in Alzheimer’s Disease Pathology
Cardiometabolic Modification of Amyloid Beta in Alzheimer’s Disease Pathology Open
In recent years, several studies have suggested that cardiometabolic disorders, such as diabetes, obesity, hypertension, and dyslipidemia, share strong connections with the onset of neurodegenerative disorders such as Parkinson’s and Alzhe…
View article: Antidiabetic E4orf1 protein prevents hepatic steatosis and reduces markers of aging-related cellular damage in high fat fed older mice
Antidiabetic E4orf1 protein prevents hepatic steatosis and reduces markers of aging-related cellular damage in high fat fed older mice Open
Introduction Older age is associated with greater prevalence of hyperinsulinemia, type 2 diabetes, and fatty liver disease. These metabolic conditions and aging are bidirectionally linked to mitochondrial dysfunction and telomere attrition…
View article: Neural Underpinnings of Obesity: The Role of Oxidative Stress and Inflammation in the Brain
Neural Underpinnings of Obesity: The Role of Oxidative Stress and Inflammation in the Brain Open
Obesity prevalence is increasing at an unprecedented rate throughout the world, and is a strong risk factor for metabolic, cardiovascular, and neurological/neurodegenerative disorders. While low-grade systemic inflammation triggered primar…
View article: Obesity and Diabetes Mediated Chronic Inflammation: A Potential Biomarker in Alzheimer’s Disease
Obesity and Diabetes Mediated Chronic Inflammation: A Potential Biomarker in Alzheimer’s Disease Open
Alzheimer’s disease (AD) is the sixth leading cause of death and is correlated with obesity, which is the second leading cause of preventable diseases in the United States. Obesity, diabetes, and AD share several common features, and infla…
View article: P2‐166: BRANCHED‐CHAIN AMINO ACIDS (BCAAS): A NEW PLAYER IN ALZHEIMER'S DISEASE
P2‐166: BRANCHED‐CHAIN AMINO ACIDS (BCAAS): A NEW PLAYER IN ALZHEIMER'S DISEASE Open
Alzheimer's disease (AD) is an irreversible neurodegenerative disorder that is the third leading cause of mortality in the US. AD brain is mainly characterized by accumulated plaques and tangles and diminished neurotransmitters. AD is stro…
View article: Branched-chain Amino Acid Metabolism Is Impaired in Mice and Humans with Alzheimer’s Disease (OR27-04-19)
Branched-chain Amino Acid Metabolism Is Impaired in Mice and Humans with Alzheimer’s Disease (OR27-04-19) Open
OBJECTIVES: Alzheimer's disease (AD) is an irreversible neurodegenerative disorder that is the third leading cause of mortality in the US. AD brain is mainly characterized by accumulated plaques and tangles and diminished neurotransmitters…
View article: E4orf1 protein reduces the need for endogenous insulin
E4orf1 protein reduces the need for endogenous insulin Open
Background E4orf1 protein derived from adenovirus-36 reduces glucose excursion in mice, and lowers endogenous insulin response, suggesting a reduced need for insulin. We tested if the E4orf1-mediated lowering of insulin response is due to …
View article: A MetAP2 inhibitor blocks adipogenesis, yet improves glucose uptake in cells
A MetAP2 inhibitor blocks adipogenesis, yet improves glucose uptake in cells Open
Adipose tissue expansion involves angiogenesis to remodel its capillary network. The enzymemethionine aminopeptidase 2(MetAP2) promotes angiogenesis.MetAP2 inhibitors suppress angiogenesis and have potential anti-obesity effect. However, i…
View article: E4orf1: A protein for enhancing glucose uptake despite impaired proximal insulin signaling
E4orf1: A protein for enhancing glucose uptake despite impaired proximal insulin signaling Open
E4 bypasses the proximal insulin signaling but uses the distal insulin signaling to activate pAkt and in turn Glut4 translocation to improve cellular glucose uptake. E4 offers a promising template to improve glycemic control when the proxi…
View article: Transdisciplinary Research on Energetics and Cancer: From Adipose Tissue to the American Society of Clinical Oncology (ASCO) Summit Recommendations
Transdisciplinary Research on Energetics and Cancer: From Adipose Tissue to the American Society of Clinical Oncology (ASCO) Summit Recommendations Open
In 2003, The New England Journal of Medicine published a landmark paper by Dr. Eugenia Calle that documented increased risk of death from a broad number of cancers among adults with obesity, as compared to normal weight adults (1). While t…
View article: E4orf1 Enhances Glucose Uptake Independent of Proximal Insulin Signaling
E4orf1 Enhances Glucose Uptake Independent of Proximal Insulin Signaling Open
Impaired proximal insulin signaling is often present in diabetes. Hence, approaches to enhance glucose disposal independent of proximal insulin signaling are desirable. Evidence indicates that Adenovirus-derived E4orf1 protein may offer su…
View article: Age Dependent Accumulation of Spontaneous DNA Damage in Liver of Transgenic Mice over Expressing Ribosomal Protein S3
Age Dependent Accumulation of Spontaneous DNA Damage in Liver of Transgenic Mice over Expressing Ribosomal Protein S3 Open
Oxidative stress has been associated with the aging process and increased cancer incidence mainly due to accumulation of free radical dependent cellular damage.Reactive oxygen species (ROS) induced formation of 7,8-dihydro-8-oxoguanine (8-…