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View article: Serum TNF -α, IL-10 and IL-2 Trajectories and Outcomes in NSCLC and Melanoma Under Anti-PD-1 Therapy: Longitudinal Real-World Evidence from a Single Center
Serum TNF -α, IL-10 and IL-2 Trajectories and Outcomes in NSCLC and Melanoma Under Anti-PD-1 Therapy: Longitudinal Real-World Evidence from a Single Center Open
This prospective single-center study examined associations between serum cytokines—TNF-α, IL-2, and IL-10—and outcomes in stage IV non-small cell lung cancer (NSCLC, n = 43) and melanoma (n = 15) patients treated with Nivolumab at the Onco…
View article: Enhanced Stability of Multi-Functionalized Gold Nanoparticles and Potential Anticancer Efficacy on Human Cervical Cancer Cells
Enhanced Stability of Multi-Functionalized Gold Nanoparticles and Potential Anticancer Efficacy on Human Cervical Cancer Cells Open
Objectives: In this research study, we introduce a novel approach to develop an innovative nanocarrier system comprising gold nanoparticles (GNPs) loaded with doxorubicin (D) in combination with natural molecules, such as trans-resveratrol…
View article: Immune Cell–Cytokine Interplay in NSCLC and Melanoma: A Pilot Longitudinal Study of Dynamic Biomarker Interactions
Immune Cell–Cytokine Interplay in NSCLC and Melanoma: A Pilot Longitudinal Study of Dynamic Biomarker Interactions Open
The tumor microenvironment (TME) in advanced solid tumors is determined by immune checkpoints (PD-1, CTLA-4, and CD95) and cytokine networks (IL-2, IL-10, and TNF-α) that drive CD8+ T cell exhaustion, metabolic reprogramming, and apoptosis…
View article: Investigating the Osteoregenerative Properties of Juglans regia L. Extract on Mesenchymal Stem Cells and Osteoblasts Through Evaluation of Bone Markers: A Pilot Study
Investigating the Osteoregenerative Properties of Juglans regia L. Extract on Mesenchymal Stem Cells and Osteoblasts Through Evaluation of Bone Markers: A Pilot Study Open
Bone tissue regeneration is a complex process that takes place at the level of osteoblasts derived from mesenchymal cells and occurs under the action of multiple signaling pathways and through the expression of osteoregenerative markers. T…
View article: Composition and Neurogenetic Effects of Embryonic Cerebrospinal Fluid: A Systematic Review
Composition and Neurogenetic Effects of Embryonic Cerebrospinal Fluid: A Systematic Review Open
Embryonic cerebrospinal fluid (E-CSF) has an important role in neurological development. Due to limited availability, the composition and properties of E-CSF are not known to the present. Our review aims to offer a comprehensive perspectiv…
View article: THE EFFECT OF GOLD NANOPARTICLES SYNTHESIZED BY SODIUM CITRATE AND FUNCTIONALIZED WITH ANTICANCER AND NATURAL COMPOUNDS ON CANCER CELL LINES
THE EFFECT OF GOLD NANOPARTICLES SYNTHESIZED BY SODIUM CITRATE AND FUNCTIONALIZED WITH ANTICANCER AND NATURAL COMPOUNDS ON CANCER CELL LINES Open
Natural compounds, such as trans-resveratrol, R, piperine, P, and icariin, Ic, have antioxidant and anti-inflammatory properties, and potential anticancer activity. Gold nanoparticles, GNPs, are biocompatible and can be used as carriers fo…
View article: A graphene–poly(methacrylic acid)–gold bipyramid hybrid plasmonic nanocomposite for <i>in vitro</i> bioimaging and photothermal therapy
A graphene–poly(methacrylic acid)–gold bipyramid hybrid plasmonic nanocomposite for <i>in vitro</i> bioimaging and photothermal therapy Open
Novel nanocomposites based on graphene, poly(methacrylic acid) and gold bipyramidal particles function like efficient photothermal and label-free contrast agents.
View article: IN VIVO INOCULATION OF GBM CELLS IN RATS AND TREATMENT WITH RUXOLITINIB
IN VIVO INOCULATION OF GBM CELLS IN RATS AND TREATMENT WITH RUXOLITINIB Open
GlioStat (patent pending) denotes an invention that addresses the current deficiencies of glioblastoma (GBM) chemotherapy by developing a molecularly imprinted drug reservoir that is specifically designed for post-surgical recovery. The go…
View article: Dual-Modal Near-Infrared Organic Nanoparticles: Integrating Mild Hyperthermia Phototherapy with Fluorescence Imaging
Dual-Modal Near-Infrared Organic Nanoparticles: Integrating Mild Hyperthermia Phototherapy with Fluorescence Imaging Open
Specifically tailored for dual-modal NIR functionality, our NPs offer a novel approach in cancer PTT and real-time fluorescence monitoring, signaling a promising avenue toward clinical translation.
View article: ANTIMICROBIAL EFFECT OF TOOTHPASTES CONTAINING BIRCH EXTRACT AND NANO-HYDROXYAPATITES
ANTIMICROBIAL EFFECT OF TOOTHPASTES CONTAINING BIRCH EXTRACT AND NANO-HYDROXYAPATITES Open
The study investigates the antimicrobial efficacy of toothpaste formulations incorporating nano-hydroxyapatite (nHAP) and birch extract. Toothpastes were evaluated for their ability to inhibit bacterial growth, with observations revealing …
View article: The transcriptional landscape of cancer stem-like cell functionality in breast cancer
The transcriptional landscape of cancer stem-like cell functionality in breast cancer Open
Background Cancer stem-like cells (CSCs) have been extensively researched as the primary drivers of therapy resistance and tumor relapse in patients with breast cancer. However, due to lack of specific molecular markers, increased phenotyp…
View article: Dynamics of Dental Enamel Surface Remineralization under the Action of Toothpastes with Substituted Hydroxyapatite and Birch Extract
Dynamics of Dental Enamel Surface Remineralization under the Action of Toothpastes with Substituted Hydroxyapatite and Birch Extract Open
To address tooth enamel demineralization resulting from factors such as acid erosion, abrasion, and chronic illness treatments, it is important to develop effective daily dental care products promoting enamel preservation and surface remin…
View article: Recommendations from the COST action CA17116 (SPRINT) for the standardization of perinatal derivative preparation and in vitro testing
Recommendations from the COST action CA17116 (SPRINT) for the standardization of perinatal derivative preparation and in vitro testing Open
Many preclinical studies have shown that birth-associated tissues, cells and their secreted factors, otherwise known as perinatal derivatives (PnD), possess various biological properties that make them suitable therapeutic candidates for t…
View article: Optimization of Functional Toothpaste Formulation Containing Nano-Hydroxyapatite and Birch Extract for Daily Oral Care
Optimization of Functional Toothpaste Formulation Containing Nano-Hydroxyapatite and Birch Extract for Daily Oral Care Open
This research work aims to develop functional toothpastes with combined enamel remineralization and antibacterial effects using nano-hydroxyapatites (nHAPs) and birch extract. Eleven toothpastes (notated as P1–P11) were designed featuring …
View article: Remineralization Induced by Biomimetic Hydroxyapatite Toothpastes on Human Enamel
Remineralization Induced by Biomimetic Hydroxyapatite Toothpastes on Human Enamel Open
This work aimed to compare the effect of four new toothpastes (P1–P4) based on pure and biomimetic substituted nano-hydroxyapatites (HAPs) on remineralization of human enamel. Artificially demineralized enamel slices were daily treated for…
View article: The Bioactive Properties of Carotenoids from Lipophilic Sea buckthorn Extract (Hippophae rhamnoides L.) in Breast Cancer Cell Lines
The Bioactive Properties of Carotenoids from Lipophilic Sea buckthorn Extract (Hippophae rhamnoides L.) in Breast Cancer Cell Lines Open
In women, breast cancer is the most commonly diagnosed cancer (11.7% of total cases) and the leading cause of cancer death (6.9%) worldwide. Bioactive dietary components such as Sea buckthorn berries are known for their high carotenoid con…
View article: Ruxolitinib-Loaded Imprinted Polymeric Drug Reservoir for the Local Management of Post-Surgical Residual Glioblastoma Cells
Ruxolitinib-Loaded Imprinted Polymeric Drug Reservoir for the Local Management of Post-Surgical Residual Glioblastoma Cells Open
(1) Background: The current limitations of glioblastoma (GBM) chemotherapy were addressed by developing a molecularly imprinted polymer (MIP)-based drug reservoir designed for the localized and sustained release of ruxolitinib (RUX) within…
View article: Flaxseed Ethanol Extracts’ Antitumor, Antioxidant, and Anti-Inflammatory Potential
Flaxseed Ethanol Extracts’ Antitumor, Antioxidant, and Anti-Inflammatory Potential Open
The antitumoral, antioxidant, and anti-inflammatory effects of flaxseed ethanol extract was screened. Phytochemical analysis was performed by measuring the total phenolic content and by HPLC-DAD-ESI MS. In vitro antiproliferative activity …
View article: Ferroptosis Involvement in Glioblastoma Treatment
Ferroptosis Involvement in Glioblastoma Treatment Open
Glioblastoma multiforme (GBM) is one of the deadliest brain tumors. Current standard therapy includes tumor resection surgery followed by radiotherapy and chemotherapy. Due to the tumors invasive nature, recurrences are almost a certainty,…
View article: BMP-2 Delivery through Liposomes in Bone Regeneration
BMP-2 Delivery through Liposomes in Bone Regeneration Open
Bone regeneration is a central focus of maxillofacial research, especially when dealing with dental implants or critical sized wound sites. While bone has great regeneration potential, exogenous delivery of growth factors can greatly enhan…
View article: Potential Biomarkers for the Efficacy of PD-1-PD-L Blockade in Cancer
Potential Biomarkers for the Efficacy of PD-1-PD-L Blockade in Cancer Open
A decade ago, immune checkpoint blockade emerged as a major breakthrough in oncology, proposing a novel approach by which immune brakes could be released to enhance antitumor responses. Despite apparently modest improvement of the median d…
View article: The Future of Stem Cells and Their Derivates in the Treatment of Glaucoma. A Critical Point of View
The Future of Stem Cells and Their Derivates in the Treatment of Glaucoma. A Critical Point of View Open
This review focuses on the clinical translation of preclinical studies, especially those that have used stem cells in the treatment of glaucoma, with an emphasis on optic nerve regeneration. The studies referred to in the review aim to tre…
View article: 190 Perioperative dynamic evaluation of folate receptor alpha expression in ovarian carcinoma
190 Perioperative dynamic evaluation of folate receptor alpha expression in ovarian carcinoma Open
Introduction/Background* The human folate receptor α (FOLR1) is overexpressed in ovarian cancer and has been correlated with the transformed phenotype in ovarian cancer, platinum sensitivity, and tumor growth. The highly restricted distrib…
View article: Predictive factors for the recurrence of surgically excised basal cell carcinomas: A retrospective clinical and immunopathological pilot study
Predictive factors for the recurrence of surgically excised basal cell carcinomas: A retrospective clinical and immunopathological pilot study Open
Basal cell carcinoma (BCC) is the most frequent form of skin cancer and is not a tumor with a lethal outcome if diagnosed and treated adequately. The gold standard for treatment is surgical excision with histologically safe margins. Even s…
View article: Multilayered Porous Titanium-Based 3rd Generation Biomaterial Designed for Endosseous Implants
Multilayered Porous Titanium-Based 3rd Generation Biomaterial Designed for Endosseous Implants Open
This work proposes a novel complex multi-layered material consisting of porous titanium as a substrate and a complex coating consisting of a chitosan film engulfing microsphere loaded with growth factors such as BMP2 (bone morphogenic prot…
View article: A narrative review of central nervous system involvement in acute leukemias
A narrative review of central nervous system involvement in acute leukemias Open
Acute leukemias (both myeloid and lymphoblastic) are a group of diseases for which each year more successful therapies are implemented. However, in a subset of cases the overall survival (OS) is still exceptionally low due to the infiltrat…
View article: Perinatal Derivatives: Where Do We Stand? A Roadmap of the Human Placenta and Consensus for Tissue and Cell Nomenclature
Perinatal Derivatives: Where Do We Stand? A Roadmap of the Human Placenta and Consensus for Tissue and Cell Nomenclature Open
Progress in the understanding of the biology of perinatal tissues has contributed to the breakthrough revelation of the therapeutic effects of perinatal derivatives (PnD), namely birth-associated tissues, cells, and secreted factors. The s…
View article: Cannabidiol and Vitamin D3 Impact on Osteogenic Differentiation of Human Dental Mesenchymal Stem Cells
Cannabidiol and Vitamin D3 Impact on Osteogenic Differentiation of Human Dental Mesenchymal Stem Cells Open
Background and objective: The aim of the present study was to establish a new differentiation protocol using cannabidiol (CBD) and vitamin D3 (Vit. D3) for a better and faster osteogenic differentiation of dental tissue derived mesenchymal…