Vicky Alexiou
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View article: Synovial tissue atlas in juvenile idiopathic arthritis reveals pathogenic niches associated with disease severity
Synovial tissue atlas in juvenile idiopathic arthritis reveals pathogenic niches associated with disease severity Open
Precision application of targeted therapies is urgently needed to improve long-term clinical outcomes for children affected by inflammatory arthritis, known as juvenile idiopathic arthritis (JIA). Progress has been hampered by our limited …
View article: The immune landscape of the inflamed joint defined by spectral flow cytometry
The immune landscape of the inflamed joint defined by spectral flow cytometry Open
Cellular phenotype and function are altered in different microenvironments. For targeted therapies it is important to understand site-specific cellular adaptations. Juvenile idiopathic arthritis (JIA) is characterized by autoimmune joint i…
View article: The immune landscape of the inflamed joint defined by spectral flow cytometry
The immune landscape of the inflamed joint defined by spectral flow cytometry Open
Cellular phenotype and function are altered in different microenvironments. For targeted therapies it is important to understand site-specific cellular adaptations. Juvenile Idiopathic Arthritis (JIA) is characterised by joint inflammation…
View article: OA32 Minimally invasive, ultrasound-guided tissue biopsies of synovial tissue in children with Juvenile Idiopathic Arthritis for research: a feasibility study
OA32 Minimally invasive, ultrasound-guided tissue biopsies of synovial tissue in children with Juvenile Idiopathic Arthritis for research: a feasibility study Open
Introduction/Background When investigating disease mechanisms, site-specific differences in immune cell phenotype and function have highlighted the need to analyse cellular and molecular mechanisms at the tissue site directly. In adults, t…