Victor Bobée
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View article: Overestimation of Automated Platelet Counts by Blast Fragments in Acute Hypercellular Leukemias: A Retrospective Study Comparing Impedance, Optical (<scp>PLT</scp>‐O), Fluorescent (<scp>PLT</scp>‐F), and <scp>CD41</scp>/<scp>CD61</scp> Flow Cytometry Methods
Overestimation of Automated Platelet Counts by Blast Fragments in Acute Hypercellular Leukemias: A Retrospective Study Comparing Impedance, Optical (<span>PLT</span>‐O), Fluorescent (<span>PLT</span>‐F), and <span>CD41</span>/<span>CD61</span> Flow Cytometry Methods Open
Introduction Acute leukemias with hyperleukocytosis (> 100 × 10 9 /L) can produce cytoplasmic blast fragments that interfere with platelet counts, notably in impedance‐based methods, potentially masking severe thrombocytopenia and increasi…
View article: Comprehensive analysis of sickle β+-thalassemia genotypes and their associated HbA levels in France
Comprehensive analysis of sickle β+-thalassemia genotypes and their associated HbA levels in France Open
We retrospectively reviewed the clinical records of 228 HbS/β+-thal patients. The different genotypes were distributed into three groups according to their mean residual HbA levels: 20 % (group 3; n = 31). Routine red blood cel…
View article: Comprehensive Analysis of Sickle Β+-Thalassemia Genotypes and Their Associated Hba Levels in France
Comprehensive Analysis of Sickle Β+-Thalassemia Genotypes and Their Associated Hba Levels in France Open
View article: Blastic Plasmocytoid Dendritic Cell Neoplasm With Pseudo‐Lymphoid Morphology Mimicking Lymphoid Malignancy
Blastic Plasmocytoid Dendritic Cell Neoplasm With Pseudo‐Lymphoid Morphology Mimicking Lymphoid Malignancy Open
View article: Relapse of Monomorphic Epitheliotropic Intestinal T‐Cell Lymphoma (<scp>MEITL</scp>) in a Pericardial Fluid
Relapse of Monomorphic Epitheliotropic Intestinal T‐Cell Lymphoma (<span>MEITL</span>) in a Pericardial Fluid Open
View article: Identification of primary mediastinal B-cell lymphomas with higher clonal dominance and poorer outcome using 5′RACE
Identification of primary mediastinal B-cell lymphomas with higher clonal dominance and poorer outcome using 5′RACE Open
There is a scarcity of data on the tumor B-cell receptor (BCR) repertoire and lymphoid microenvironment in primary mediastinal B-cell lymphoma (PMBL). We applied 5ʹ rapid amplification of complimentary DNA ends (5′RACE) to tumor RNA sample…
View article: Analysis of immunoglobulin/T‐cell receptor repertoires by high‐throughput RNA sequencing reveals a continuous dynamic of positive clonal selection in follicular lymphoma
Analysis of immunoglobulin/T‐cell receptor repertoires by high‐throughput RNA sequencing reveals a continuous dynamic of positive clonal selection in follicular lymphoma Open
Follicular lymphoma (FL) course is highly variable, making its clinical management challenging. In this incurable and recurring pathology, the interval between relapses tends to decrease while aggressiveness increases, sometimes resulting …
View article: Four Cases of Myeloproliferative Disorders Associated With Down Syndrome: Distinguishing ML‐DS From TAM‐DS
Four Cases of Myeloproliferative Disorders Associated With Down Syndrome: Distinguishing ML‐DS From TAM‐DS Open
Down syndrome (DS) is defined by an extra copy of chromosome 21 and confers an increased susceptibility to hematological disorders. Transient abnormal myelopoiesis (TAM) and myeloid‐leukemia associated with Down syndrome (ML‐DS) are two co…
View article: PB0210 Heterozygous Structural Variation Mimicking Homozygous Substitution in MCFD2 in a French Patient with Combined Factor V and Factor VIII Deficiency
PB0210 Heterozygous Structural Variation Mimicking Homozygous Substitution in MCFD2 in a French Patient with Combined Factor V and Factor VIII Deficiency Open
asymptomatic phenotype.BAT in a group of bleeding patients was ranged 1-4, most often presented by epistaxis, bruising and menorrhagia. Conclusion(s):The majority of dysfibrinogenemic patients in our cohort with hotspot mutation of p.Arg35…
View article: Germline JAK2 E846D Substitution as the Cause of Erythrocytosis?
Germline JAK2 E846D Substitution as the Cause of Erythrocytosis? Open
The discovery in 2005 of the JAK2 V617F gain-of-function mutation in myeloproliferative neoplasms and more particularly in polycythemia vera has deeply changed the diagnostic and therapeutic approaches to polycythemia. More recently, the u…
View article: Caractérisation de l'hétérogénéité moléculaire des lymphomes B et de leur micro-environnement par des techniques innovantes
Caractérisation de l'hétérogénéité moléculaire des lymphomes B et de leur micro-environnement par des techniques innovantes Open
Lymphomas are the 5th most common cancer in France with approximately 22,000 new cases diagnosed each year. There is a considerable clinical and biological heterogeneity in these tumors, and the latest classification of the World Health Or…
View article: Integrative diagnosis of primary cutaneous large B-cell lymphomas supports the relevance of cell of origin profiling
Integrative diagnosis of primary cutaneous large B-cell lymphomas supports the relevance of cell of origin profiling Open
Primary cutaneous large B-cell lymphomas (PCLBCL) represent a diagnostic challenge because they are classified as PCLBCL, leg type (PCLBCL, LT) or primary cutaneous follicle centre lymphoma, large cell (PCFCL, LC), which differ by prognosi…
View article: Dissociated humoral and cellular immune responses after a three-dose schema of BNT162b2 vaccine in patients receiving anti-CD20 monoclonal antibody maintenance treatment for B-cell lymphomas
Dissociated humoral and cellular immune responses after a three-dose schema of BNT162b2 vaccine in patients receiving anti-CD20 monoclonal antibody maintenance treatment for B-cell lymphomas Open
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View article: Concomitant occurrence of genetically distinct Hodgkin lymphoma and primary mediastinal lymphoma
Concomitant occurrence of genetically distinct Hodgkin lymphoma and primary mediastinal lymphoma Open
Synchronous Hodgkin Lymphoma and Primary Mediastinal B‐cell Lymphoma is possible, with molecular analyses proving the absence of clonal filiation between both entities. This suggests a common etiology but the existence of two divergent clo…
View article: Erythrocyte hemighosts in a patient with tumor lysis syndrome: One train may hide another
Erythrocyte hemighosts in a patient with tumor lysis syndrome: One train may hide another Open
Rasburicase was introduced to treat hyperuricemia secondary to tumor lysis syndrome. Because of severe hemolytic anemia, a blood smear was requested and showed hemighosts, revealing G6PD deficiency. Erythrocyte morphology is a key tool in …
View article: Hereditary pyropoïkilocytosis diagnosis in an infant: benefit of histograms and peripheral smear review
Hereditary pyropoïkilocytosis diagnosis in an infant: benefit of histograms and peripheral smear review Open
View article: Combining gene expression profiling and machine learning to diagnose B-cell non-Hodgkin lymphoma
Combining gene expression profiling and machine learning to diagnose B-cell non-Hodgkin lymphoma Open
View article: Benefit of Howell-Jolly bodies detection: finding of an acquired hyposplenism in a patient with Goodpasture syndrome
Benefit of Howell-Jolly bodies detection: finding of an acquired hyposplenism in a patient with Goodpasture syndrome Open
Howell-Jolly bodies are intraerythrocytic inclusions corresponding to a small portion of chromatin. Red blood cells that contain these nuclear remnants are removed from the circulation by the spleen. In most cases, presence of Howell-Jolly…
View article: Numerous Heinz bodies in a case of infantile pyknocytosis
Numerous Heinz bodies in a case of infantile pyknocytosis Open
View article: Determination of Molecular Subtypes of Diffuse Large B-Cell Lymphoma Using a Reverse Transcriptase Multiplex Ligation-Dependent Probe Amplification Classifier
Determination of Molecular Subtypes of Diffuse Large B-Cell Lymphoma Using a Reverse Transcriptase Multiplex Ligation-Dependent Probe Amplification Classifier Open
View article: Détermination moléculaire des sous-types de lymphomes B diffus à grandes cellules par un classifieur de type retrotranscription multiplex ligation-dependent probe amplification
Détermination moléculaire des sous-types de lymphomes B diffus à grandes cellules par un classifieur de type retrotranscription multiplex ligation-dependent probe amplification Open
Les lymphomes B diffus a grandes cellules (LBDGC) representent 40% des lymphomes non-hodgkiniens. Leur heterogeneite a ete revelee par les profils d’expression genique, permettant un classement en deux sous-types moleculaires : Germinal Ce…
View article: Diagnostic Value of Antigen-Specific Immunoglobulin E Immunoassays against Ara h 2 and Ara h 8 Peanut Components in Child Food Allergy
Diagnostic Value of Antigen-Specific Immunoglobulin E Immunoassays against Ara h 2 and Ara h 8 Peanut Components in Child Food Allergy Open
Background: Peanut allergy is one of the most severe food allergies in children. The diagnostic gold standard is the oral food challenge (OFC). However, OFC has inherent risks and is time consuming. The measurement of specific immunoglobul…