Víctor Galván-Álvarez
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View article: Human Pharmacokinetic Profiling and Comparative Analysis of Mangiferin and Its Monosodium Derivative from Mangifera indica Extracts Using UHPLC-MS/MS with 1H NMR and MALDI-TOF Confirmation
Human Pharmacokinetic Profiling and Comparative Analysis of Mangiferin and Its Monosodium Derivative from Mangifera indica Extracts Using UHPLC-MS/MS with 1H NMR and MALDI-TOF Confirmation Open
Mangiferin, a glucosyl xanthone, is a plant metabolite with promising nootropic and ergogenic properties. However, its poor and inconsistent systemic bioavailability limits its therapeutic potential. Additionally, the pharmacokinetics of m…
View article: CaMKII protein expression and phosphorylation in human skeletal muscle by immunoblotting: Isoform specificity
CaMKII protein expression and phosphorylation in human skeletal muscle by immunoblotting: Isoform specificity Open
Calcium (Ca2+)/calmodulin-dependent protein kinase II (CaMKII) is activated during exercise by reactive oxygen species (ROS) and Ca2+ transients initiating muscle contraction. CaMKII modulates antioxidant, inflammator…
View article: Remodeling p38 signaling in muscle controls locomotor activity via IL-15
Remodeling p38 signaling in muscle controls locomotor activity via IL-15 Open
Skeletal muscle has gained recognition as an endocrine organ releasing myokines upon contraction during physical exercise. These myokines exert both local and pleiotropic health benefits, underscoring the crucial role of muscle function in…
View article: Unlocking peak performance: The role of Nrf2 in enhancing exercise outcomes and training adaptation in humans
Unlocking peak performance: The role of Nrf2 in enhancing exercise outcomes and training adaptation in humans Open
Since the discovery of the nuclear factor erythroid-derived 2-like 2 (Nrf2) transcription factor thirty years ago, it has been shown that it regulates more than 250 genes involved in a multitude of biological processes, including redox bal…
View article: Assessing Leg Blood Flow and Cardiac Output During Running Using Thermodilution
Assessing Leg Blood Flow and Cardiac Output During Running Using Thermodilution Open
Cardiac output (Q̇ C ) and leg blood flow (Q̇ LEG ) can be measured simultaneously with high accuracy using transpulmonary and femoral vein thermodilution with a single‐bolus injection. The invasive measure has offered important insight into…
View article: Activation of macroautophagy and chaperone-mediated autophagy in human skeletal muscle by high-intensity exercise in normoxia and hypoxia and after recovery with or without post-exercise ischemia
Activation of macroautophagy and chaperone-mediated autophagy in human skeletal muscle by high-intensity exercise in normoxia and hypoxia and after recovery with or without post-exercise ischemia Open
Autophagy is essential for the adaptive response to exercise and physiological skeletal muscle functionality. However, the mechanisms leading to the activation of macroautophagy and chaperone-mediated autophagy in human skeletal muscle in …
View article: Physiological and molecular predictors of cycling sprint performance
Physiological and molecular predictors of cycling sprint performance Open
The study aimed to identify novel muscle phenotypic factors that could determine sprint performance using linear regression models including the lean mass of the lower extremities (LLM), myosin heavy chain composition (MHC), and proteins a…
View article: Antioxidant enzymes and Nrf2/Keap1 in human skeletal muscle: Influence of age, sex, adiposity and aerobic fitness
Antioxidant enzymes and Nrf2/Keap1 in human skeletal muscle: Influence of age, sex, adiposity and aerobic fitness Open
View article: Determinants of the maximal functional reserve during repeated supramaximal exercise by humans: The roles of Nrf2/Keap1, antioxidant proteins, muscle phenotype and oxygenation
Determinants of the maximal functional reserve during repeated supramaximal exercise by humans: The roles of Nrf2/Keap1, antioxidant proteins, muscle phenotype and oxygenation Open
When high-intensity exercise is performed until exhaustion a "functional reserve" (FR) or capacity to produce power at the same level or higher than reached at exhaustion exists at task failure, which could be related to reactive oxygen an…
View article: A Mango Leaf Extract (Zynamite®) Combined with Quercetin Has Exercise-Mimetic Properties in Human Skeletal Muscle
A Mango Leaf Extract (Zynamite®) Combined with Quercetin Has Exercise-Mimetic Properties in Human Skeletal Muscle Open
Zynamite PX®, a mango leaf extract combined with quercetin, enhances exercise performance by unknown molecular mechanisms. Twenty-five volunteers were assigned to a control (17 males) or supplementation group (8 males, receiving 140 mg of …
View article: Architectural anatomy of the human tibialis anterior presents morphological asymmetries between superficial and deep unipennate regions
Architectural anatomy of the human tibialis anterior presents morphological asymmetries between superficial and deep unipennate regions Open
The tibialis anterior muscle plays a critical role in human ambulation and contributes to maintaining the upright posture. However, little is known about its muscle architecture in males and females. One hundred and nine physically active …
View article: Accurate assessment of walking energy expenditure in the main seafront walking route of Las Palmas de Gran Canaria to promote health-related tourism
Accurate assessment of walking energy expenditure in the main seafront walking route of Las Palmas de Gran Canaria to promote health-related tourism Open
This investigation aimed to determine the energy
\nexpenditure incurred by males and females in the most
\npopular walking route in Las Palmas de Gran Canaria
\nusing state-of-the-art methods. The energy expended in
\nthe main walking rout…
View article: Fast regulation of the NF-κB signalling pathway in human skeletal muscle revealed by high-intensity exercise and ischaemia at exhaustion: Role of oxygenation and metabolite accumulation
Fast regulation of the NF-κB signalling pathway in human skeletal muscle revealed by high-intensity exercise and ischaemia at exhaustion: Role of oxygenation and metabolite accumulation Open
View article: Treatment of hypertension with angiotensin‐converting enzyme inhibitors or angiotensin receptor blockers and resting metabolic rate: A cross‐sectional study
Treatment of hypertension with angiotensin‐converting enzyme inhibitors or angiotensin receptor blockers and resting metabolic rate: A cross‐sectional study Open
Hypertension in obese and overweight patients is associated with an elevated resting metabolic rate (RMR). The aim of this study was to determine whether RMR is reduced in hypertensive patients treated with angiotensin‐converting enzyme in…
View article: Angiotensin‐Converting Enzyme 2 (SARS‐CoV‐2 receptor) expression in human skeletal muscle
Angiotensin‐Converting Enzyme 2 (SARS‐CoV‐2 receptor) expression in human skeletal muscle Open
The study aimed to determine the levels of skeletal muscle angiotensin‐converting enzyme 2 (ACE2, the SARS‐CoV‐2 receptor) protein expression in men and women and assess whether ACE2 expression in skeletal muscle is associated with cardior…
View article: Functional reserve and sex differences during exercise to exhaustion revealed by post‐exercise ischaemia and repeated supramaximal exercise
Functional reserve and sex differences during exercise to exhaustion revealed by post‐exercise ischaemia and repeated supramaximal exercise Open
Key points Females have lower fatigability than males during single limb isometric and dynamic contractions, but whether sex‐differences exist during high‐intensity whole‐body exercise remains unknown. This study shows that males and femal…
View article: Resting metabolic rate is increased in hypertensive patients with overweight or obesity: Potential mechanisms
Resting metabolic rate is increased in hypertensive patients with overweight or obesity: Potential mechanisms Open
The purpose of this investigation was to determine whether differences in body composition, pharmacological treatment, and physical activity explain the increased resting metabolic rate (RMR) and impaired insulin sensitivity in hypertensio…
View article: Supplementation with a Mango Leaf Extract (Zynamite®) in Combination with Quercetin Attenuates Muscle Damage and Pain and Accelerates Recovery after Strenuous Damaging Exercise
Supplementation with a Mango Leaf Extract (Zynamite®) in Combination with Quercetin Attenuates Muscle Damage and Pain and Accelerates Recovery after Strenuous Damaging Exercise Open
Prolonged or unusual exercise may cause exercise-induced muscle damage (EIMD). To test whether Zynamite®, a mango leaf extract rich in the natural polyphenol mangiferin, administered in combination with quercetin facilitates recovery after…
View article: Resting Energy Expenditure and Body Composition in Overweight Men and Women Living in a Temperate Climate
Resting Energy Expenditure and Body Composition in Overweight Men and Women Living in a Temperate Climate Open
This study aimed to determine whether the measured resting energy expenditure (REE) in overweight and obese patients living in a temperate climate is lower than the predicted REE; and to ascertain which equation should be used in patients …
View article: A Single Dose of The Mango Leaf Extract Zynamite® in Combination with Quercetin Enhances Peak Power Output During Repeated Sprint Exercise in Men and Women
A Single Dose of The Mango Leaf Extract Zynamite® in Combination with Quercetin Enhances Peak Power Output During Repeated Sprint Exercise in Men and Women Open
The mango leaf extract rich in mangiferin Zynamite® improves exercise performance when combined with luteolin or quercetin ingested at least 48 h prior to exercise. To determine whether a single dose of Zynamite® administered 1 h before ex…
View article: Enhancement of Exercise Performance by 48 Hours, and 15-Day Supplementation with Mangiferin and Luteolin in Men
Enhancement of Exercise Performance by 48 Hours, and 15-Day Supplementation with Mangiferin and Luteolin in Men Open
The natural polyphenols mangiferin and luteolin have free radical-scavenging properties, induce the antioxidant gene program and down-regulate the expression of superoxide-producing enzymes. However, the effects of these two polyphenols on…
View article: Accuracy and Precision of the COSMED K5 Portable Analyser
Accuracy and Precision of the COSMED K5 Portable Analyser Open
The main aims of this study were to determine the accuracy of the portable metabolic cart K5 by comparison with a stationary metabolic cart (Vyntus CPX), to check on the validity of Vyntus CPX using a butane combustion test, and to assess …
View article: Mangifera indica L. Leaf Extract in Combination With Luteolin or Quercetin Enhances VO2peak and Peak Power Output, and Preserves Skeletal Muscle Function During Ischemia-Reperfusion in Humans
Mangifera indica L. Leaf Extract in Combination With Luteolin or Quercetin Enhances VO2peak and Peak Power Output, and Preserves Skeletal Muscle Function During Ischemia-Reperfusion in Humans Open
It remains unknown whether polyphenols such as luteolin (Lut), mangiferin and quercetin (Q) have ergogenic effects during repeated all-out prolonged sprints. Here we tested the effect of Mangifera indica L. leaf extract (MLE) rich i…