Victor I. Reus
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View article: Characterisation of serious mental illness trajectories through transdiagnostic clinical features
Characterisation of serious mental illness trajectories through transdiagnostic clinical features Open
Background Electronic health records (EHRs), increasingly available in low- and middle-income countries (LMICs), provide an opportunity to study transdiagnostic features of serious mental illness (SMI) and its trajectories. Aims Characteri…
View article: Leveraging NLP for Psychiatric Phenotyping from Spanish EHR: Enabling the Investigation of Transdiagnostic Symptom Profiles at Scale
Leveraging NLP for Psychiatric Phenotyping from Spanish EHR: Enabling the Investigation of Transdiagnostic Symptom Profiles at Scale Open
Clinical notes in electronic health records (EHRs) offer valuable insight into the symptom profiles and trajectories of patients with severe mental illness (SMI). However, systematically extracting symptoms at scale remains a challenge, es…
View article: Kynurenine Metabolism is Associated with Antidepressant Response to Selective Serotonin Reuptake Inhibitors
Kynurenine Metabolism is Associated with Antidepressant Response to Selective Serotonin Reuptake Inhibitors Open
Alterations in the kynurenine pathway, and in particular the balance of neuroprotective and neurotoxic metabolites, have been implicated in the pathophysiology of Major Depressive Disorder (MDD) and antidepressant treatment response. In th…
View article: Predicting Diagnostic Conversion From Major Depressive Disorder to Bipolar Disorder: An <scp>EHR</scp> Based Study From Colombia
Predicting Diagnostic Conversion From Major Depressive Disorder to Bipolar Disorder: An <span>EHR</span> Based Study From Colombia Open
Objectives Most bipolar disorder (BD) patients initially present with depressive symptoms, resulting in a delayed diagnosis of BD and poor clinical outcomes. This study aims to identify features predictive of the conversion from Major Depr…
View article: Phenotype harmonization and analysis for The Populations Underrepresented in Mental illness Association Studies (the PUMAS Project)
Phenotype harmonization and analysis for The Populations Underrepresented in Mental illness Association Studies (the PUMAS Project) Open
Background The Populations Underrepresented in Mental illness Association Studies (PUMAS) project is attempting to remediate the historical underrepresentation of African and Latin American populations in psychiatric genetics through large…
View article: Geospatial investigations in Colombia reveal variations in the distribution of mood and psychotic disorders
Geospatial investigations in Colombia reveal variations in the distribution of mood and psychotic disorders Open
View article: Circulating cell-free mitochondrial DNA levels and glucocorticoid sensitivity in a cohort of male veterans with and without combat-related PTSD
Circulating cell-free mitochondrial DNA levels and glucocorticoid sensitivity in a cohort of male veterans with and without combat-related PTSD Open
View article: Predicting diagnostic conversion from major depressive disorder to bipolar disorder: an EHR based study from Colombia
Predicting diagnostic conversion from major depressive disorder to bipolar disorder: an EHR based study from Colombia Open
Bipolar Disorder (BD) is a severe and chronic disorder characterized by recurrent episodes of depression, mania, and/or hypomania. Most BD patients initially present with depressive symptoms, resulting in a delayed diagnosis of BD and poor…
View article: Shorter telomere length predicts poor antidepressant response and poorer cardiometabolic indices in major depression
Shorter telomere length predicts poor antidepressant response and poorer cardiometabolic indices in major depression Open
Telomere length (TL) is a marker of biological aging, and shorter telomeres have been associated with several medical and psychiatric disorders, including cardiometabolic dysregulation and Major Depressive Disorder (MDD). In addition, stud…
View article: Circulating cell-free mitochondrial DNA levels and glucocorticoid receptor sensitivity in combat-related PTSD
Circulating cell-free mitochondrial DNA levels and glucocorticoid receptor sensitivity in combat-related PTSD Open
Circulating cell-free mitochondrial DNA (ccf-mtDNA) is a biomarker of cellular injury or cellular stress and is a potential novel biomarker of psychological stress and of various brain, somatic, and psychiatric disorders. No studies have y…
View article: Dimensions of childhood adversity differentially affect biological aging in major depression
Dimensions of childhood adversity differentially affect biological aging in major depression Open
Adverse childhood experiences have been consistently linked with physical and mental health disorders in adulthood that may be mediated, in part, via the effects of such exposures on biological aging. Using recently developed “epigenetic c…
View article: Transdiagnostic Clinical Features Delineate Trajectories of Serious Mental Illness
Transdiagnostic Clinical Features Delineate Trajectories of Serious Mental Illness Open
Background Electronic health record (EHR) databases, increasingly available in low- and middle-income countries (LMIC), provide an opportunity to study transdiagnostic features of serious mental illness (SMI) and delineate illness trajecto…
View article: Stricter protocols combined with a clinical serum biomarker can increase replicability and causality for dietary intervention studies. Plus empirical data on BPA regrettable substitutions
Stricter protocols combined with a clinical serum biomarker can increase replicability and causality for dietary intervention studies. Plus empirical data on BPA regrettable substitutions Open
Effective regulation of harmful environmental chemicals found in wide variety of consumer products and consumables has been thwarted by the lack of agreement between government scientists and university/academic laboratories regarding the …
View article: Geospatial analysis reveals distinct hotspots of severe mental illness
Geospatial analysis reveals distinct hotspots of severe mental illness Open
Background The identification of geographic variation in incidence can be an important step in the delineation of disease risk factors, but has mostly been undertaken in upper-income countries. Here, we use Electronic Health Records (EHR) …
View article: Blood-based mitochondrial respiratory chain function in major depression
Blood-based mitochondrial respiratory chain function in major depression Open
Mitochondrial dysfunction has been implicated in major depressive disorder (MDD). A measure of mitochondrial respiratory chain (RC) enzymatic activity—the Mitochondrial Health Index (MHI)—has previously been found to correlate with stress …
View article: Development and Implementation of a Chief Resident for Research Role in a Psychiatry Residency Training Program
Development and Implementation of a Chief Resident for Research Role in a Psychiatry Residency Training Program Open
Psychiatry residency programs with robust research training can prepare physician-scientists to make contributions that advance the mental health field. Our psychiatry residency developed a chief resident for research position to help prov…
View article: Abnormal levels of mitochondrial proteins in plasma neuronal extracellular vesicles in major depressive disorder
Abnormal levels of mitochondrial proteins in plasma neuronal extracellular vesicles in major depressive disorder Open
To characterize neuronal mitochondrial abnormalities in major depressive disorder (MDD), functional mitochondrial proteins (MPs) extracted from enriched plasma neuron-derived extracellular vesicles (NDEVs) of MDD participants ( n = 20) wer…
View article: Serum brain-derived neurotrophic factor remains elevated after long term follow-up of combat veterans with chronic post-traumatic stress disorder
Serum brain-derived neurotrophic factor remains elevated after long term follow-up of combat veterans with chronic post-traumatic stress disorder Open
View article: Utilization of machine learning for identifying symptom severity military-related PTSD subtypes and their biological correlates
Utilization of machine learning for identifying symptom severity military-related PTSD subtypes and their biological correlates Open
We sought to find clinical subtypes of posttraumatic stress disorder (PTSD) in veterans 6–10 years post-trauma exposure based on current symptom assessments and to examine whether blood biomarkers could differentiate them. Samples were mal…
View article: “GrimAge,” an epigenetic predictor of mortality, is accelerated in major depressive disorder
“GrimAge,” an epigenetic predictor of mortality, is accelerated in major depressive disorder Open
View article: “GrimAge,” an epigenetic predictor of mortality, is accelerated in Major Depressive Disorder
“GrimAge,” an epigenetic predictor of mortality, is accelerated in Major Depressive Disorder Open
Major Depressive Disorder (MDD) is associated with premature mortality and is an independent risk factor for a broad range of diseases, especially those associated with aging, such as cardiovascular disease, diabetes, and Alzheimer’s Disea…
View article: Investigating hsCRP as a clinical inflammation marker for human Bisphenol A food contamination offers protocol suggestions for conducting replicable, causal dietary intervention studies
Investigating hsCRP as a clinical inflammation marker for human Bisphenol A food contamination offers protocol suggestions for conducting replicable, causal dietary intervention studies Open
Dietary intervention studies thus far have failed to be replicable or causal. The results, therefore, have failed to provide clinicians and the general public with consistent and useful information on which to base reliable food-related he…
View article: Correction: A DNA methylation clock associated with age-related illnesses and mortality is accelerated in men with combat PTSD
Correction: A DNA methylation clock associated with age-related illnesses and mortality is accelerated in men with combat PTSD Open
This Article was originally published under Nature Research’s License to Publish, but has now been made available under a [CC BY 4.0] license. The PDF and HTML versions of the Article have been modified accordingly.
View article: A DNA methylation clock associated with age-related illnesses and mortality is accelerated in men with combat PTSD
A DNA methylation clock associated with age-related illnesses and mortality is accelerated in men with combat PTSD Open
View article: Distinct and shared contributions of diagnosis and symptom domains to cognitive performance in severe mental illness in the Paisa population: a case-control study
Distinct and shared contributions of diagnosis and symptom domains to cognitive performance in severe mental illness in the Paisa population: a case-control study Open
View article: Contribution of common and rare variants to bipolar disorder susceptibility in extended pedigrees from population isolates
Contribution of common and rare variants to bipolar disorder susceptibility in extended pedigrees from population isolates Open
View article: Faculty Opinions recommendation of Synaptotagmin-7 is a key factor for bipolar-like behavioral abnormalities in mice.
Faculty Opinions recommendation of Synaptotagmin-7 is a key factor for bipolar-like behavioral abnormalities in mice. Open
The pathogenesis of bipolar disorder (BD) has remained enigmatic, largely because genetic animal models based on identified susceptible genes have often failed to show core symptoms of spontaneous mood cycling. However, pedigree and induce…
View article: Vitamin D and inflammation in major depressive disorder
Vitamin D and inflammation in major depressive disorder Open
View article: Shared Genetics of Psychiatric Disorders
Shared Genetics of Psychiatric Disorders Open
Until recently, advances in understanding the genetic architecture of psychiatric disorders have been impeded by a historic, and often mandated, commitment to the use of traditional, and unvalidated, categorical diagnoses in isolation as t…
View article: Multi-omic biomarker identification and validation for diagnosing warzone-related post-traumatic stress disorder
Multi-omic biomarker identification and validation for diagnosing warzone-related post-traumatic stress disorder Open
Post-traumatic stress disorder (PTSD) impacts many veterans and active duty soldiers, but diagnosis can be problematic due to biases in self-disclosure of symptoms, stigma within military populations, and limitations identifying those at r…